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Alcohol consumption and risks of more than 200 diseases in Chinese men
Nat Med. 2023 Jun 8. doi: 10.1038/s41591-023-02383-8. Online ahead of print.ABSTRACTAlcohol consumption accounts for ~3 million annual deaths worldwide, but uncertainty persists about its relationships with many diseases. We investigated the associations of alcohol consumption with 207 diseases in the 12-year China Kadoorie Biobank of >512,000 adults (41% men), including 168,050 genotyped for ALDH2- rs671 and ADH1B- rs1229984 , with >1.1 million ICD-10 coded hospitalized events. At baseline, 33% of men drank alcohol regularly. Among men, alcohol intake was positively associated with 61 diseases, including 33 not defi...
Source: Cancer Control - June 8, 2023 Category: Cancer & Oncology Authors: Pek Kei Im Neil Wright Ling Yang Ka Hung Chan Yiping Chen Yu Guo Huaidong Du Xiaoming Yang Daniel Avery Shaojie Wang Canqing Yu Jun Lv Robert Clarke Junshi Chen Rory Collins Robin G Walters Richard Peto Liming Li Zhengming Chen Iona Y Millwood China Kadoo Source Type: research

Mortality and Morbidity Effects of Long-Term Exposure to Low-Level PM < sub > 2.5 < /sub > , BC, NO < sub > 2 < /sub > , and O < sub > 3 < /sub > : An Analysis of European Cohorts in the ELAPSE Project
CONCLUSIONS: Long-term exposure to PM2.5, NO2, and BC was positively associated with natural-cause and cause-specific mortality in the pooled cohort and the administrative cohorts. Associations were found well below current limit values and guidelines for PM2.5 and NO2. Associations tended to be supralinear, with steeper slopes at low exposures with no indication of a threshold. Two-pollutant models documented the importance of characterizing the ambient mixture with both NO2 and PM2.5. We mostly found negative associations with O3. In two-pollutant models with NO2, the negative associations with O3 were attenuated to esse...
Source: Cancer Control - September 15, 2022 Category: Cancer & Oncology Authors: Brunekreef Bert Strak Maciej Chen Jie J Andersen Zorana Atkinson Richard Bauwelinck Mariska Bellander Tom Boutron Marie-Christine Brandt J ørgen Carey Iain Cesaroni Giulia Forastiere Francesco Fecht Daniela Gulliver John Hertel Ole Hoffmann Barbara de Ho Source Type: research

Impact of the preoperative body mass index on the postoperative outcomes in patients with completely resected non-small cell lung cancer: A retrospective analysis of 16,503 cases in a Japanese Lung Cancer Registry Study
Obesity is responsible for multiple chronic diseases, including type 2 diabetes, hypertension, coronary artery disease, stroke, and several types of cancer [1]. The body mass index (BMI) —as an easy-to obtain, acceptable proxy for thinness and fatness—has been found to be associated with health risk and death in many populations. According to the World Health Organization definition, the normal range of BMI is defined as 18.5 to
Source: Lung Cancer - September 18, 2020 Category: Cancer & Oncology Authors: Koichi Fukumoto, Shoichi Mori, Yasushi Shintani, Jiro Okami, Hiroyuki Ito, Takashi Ohtsuka, Shinichi Toyooka, Takeshi Mori, Shun-ichi Watanabe, Hisao Asamura, Masayuki Chida, Hiroshi Date, Shunsuke Endo, Takeshi Nagayasu, Ryoichi Nakanishi, Etsuo Miyaoka, Source Type: research

NAMPT as a Dedifferentiation-Inducer Gene: NAD+ as Core Axis for Glioma Cancer Stem-Like Cells Maintenance
Conclusion and Perspectives Gliomas are the most prevalent primary brain cancer in adults and include a broad category of tumors including astrocytoma, oligodendroglioma, and GBM. Regardless of tumor aggressiveness, malignancy, and infiltration, these glia-derived tumors rarely exceed a median survival time of 12–14 months. Driven by the infiltrative nature of these tumors, the clinical approach is difficult and relapses often occur with fatal consequences. These unsuccessful attempts to control glioma's fate have fostered research looking for more effective therapies. (GSCs) are a small subset of CD133&#...
Source: Frontiers in Oncology - May 2, 2019 Category: Cancer & Oncology Source Type: research

Cancers, Vol. 11, Pages 111: A Review on a Deep Learning Perspective in Brain Cancer Classification
uca Saba Jasjit S. Suri A World Health Organization (WHO) Feb 2018 report has recently shown that mortality rate due to brain or central nervous system (CNS) cancer is the highest in the Asian continent. It is of critical importance that cancer be detected earlier so that many of these lives can be saved. Cancer grading is an important aspect for targeted therapy. As cancer diagnosis is highly invasive, time consuming and expensive, there is an immediate requirement to develop a non-invasive, cost-effective and efficient tools for brain cancer characterization and grade estimation. Brain scans using magnetic resonanc...
Source: Cancers - January 18, 2019 Category: Cancer & Oncology Authors: Gopal S. Tandel Mainak Biswas Omprakash G. Kakde Ashish Tiwari Harman S. Suri Monica Turk John R. Laird Christopher K. Kwaku A. Annabel A. Ankrah N. N. Khanna B. K. Madhusudhan Luca Saba Jasjit S. Suri Tags: Review Source Type: research

World No Tobacco Day
By Stacy Simon May 31 is World No Tobacco Day, an annual awareness day sponsored by the World Health Organization (WHO) since 1987 to highlight the health risks associated with tobacco use and encourage governments to adopt effective policies to reduce smoking and other tobacco use. According to WHO, tobacco use kills nearly 6 million people around the world each year. In the United States, tobacco use is the largest preventable cause of death and disease. It causes many types of cancer, as well as heart disease, stroke, lung disease, and other health problems. This year's World No Tobacco Day theme calls on countries worl...
Source: American Cancer Society :: News and Features - May 29, 2016 Category: Cancer & Oncology Tags: Smoking/Tobacco Advocacy Source Type: news