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Study protocol for a pilot randomised controlled trial evaluating the feasibility and effectiveness of non-pharmacological interventions to recover functionality after a transient ischaemic attack or a minor stroke: the 'Back to Normal trial
This study was approved by the Ethics Committee of the Local Health Unit of Matosinhos (Ref. 75/CES/JAS). Written informed consent will be required from all the participants; data protection and confidentiality will be also ensured. The findings of this project are expected to be submitted for publication in scientific articles, and the main results will be presented at relevant scientific meetings. Trial registration number NCT05369637.
Source: BMJ Open - April 28, 2023 Category: General Medicine Authors: Goncalves, M., Lima, M. J., Fonseca, A., Duque, C., Costa, A. R., Cruz, V. T. Tags: Open access, Neurology Source Type: research

Electrolyte Imbalance and Neurologic Injury
CNS Neurol Disord Drug Targets. 2023 Feb 15. doi: 10.2174/1871527322666230215144649. Online ahead of print.ABSTRACTNeurologic injury continues to be a debilitating worldwide disease with high morbidity and mortality. The systemic sequelae of a neural insult often lead to prolonged hospital stays and challenging nutritional demands that contribute to poorer prognoses. Clinical management of a given condition should prioritize preserving the homeostatic parameters disrupted by inflammatory response cascades following the primary insult. This focused review examines the reciprocal relationship between electrolyte disturbance ...
Source: CNS and Neurological Disorders Drug Targets - February 15, 2023 Category: Drugs & Pharmacology Authors: Jordan Poe Sai Sriram Yusuf Mehkri Brandon Lucke-Wold Source Type: research

Registry for Evaluating Healthy Life Expectancy and Long-Term Outcomes after Catheter Ablation of Atrial Fibrillation in the Very Elderly (REHEALTH AF) study: rationale and design of a prospective, multicentre, observational, comparative study
Introduction Data are lacking on the extent to which patients with non-valvular atrial fibrillation (AF) who are aged ≥80 years benefit from ablation treatment. The question pertains especially to patients’ postablation quality of life (QoL) and long-term clinical outcomes. Methods and analysis We are initiating a prospective, registry-based, multicentre observational study that will include patients aged ≥80 years with non-valvular AF who choose to undergo treatment by catheter ablation and, for comparison, such patients who do not choose to undergo ablation (either according to their physician’s advice...
Source: BMJ Open - February 15, 2023 Category: General Medicine Authors: Okumura, Y., Nagashima, K., Watanabe, R., Yokoyama, K., Kato, T., Fukaya, H., Hayashi, H., Nakahara, S., Shimizu, W., Iwasaki, Y.-k., Fujimoto, Y., Mukai, Y., Ejima, K., Otsuka, T., Suzuki, S., Murakami, M., Kimura, M., Harada, M., Koyama, J., Okamatsu, H Tags: Open access, Cardiovascular medicine Source Type: research

Determinants Of In-Hospital Muscle Loss In Acute Ischemic Stroke – Results Of The Muscle Assessment In Stroke Study (Mass)
There is a change in the mass and composition of paretic and non-paretic skeletal muscles in the chronic phase of stroke. The multi-center, prospective, and observational Muscle Assessment in Stroke Study (MASS) was performed to evaluate the degree of muscle loss during the in-hospital acute stroke setting and determine factors contributing to this loss.
Source: Clinical Nutrition - February 1, 2023 Category: Nutrition Authors: Levent Gungor, Ethem Murat Arsava, Ayse Guler, Canan Togay Isikay, Ozlem Aykac, Hale Zeynep Batur Caglayan, Hasan Huseyin Kozak, Ustun Aydingoz, Mehmet Akif Topcuoglu, the Muscle Assessment in Stroke Study (MASS) investigators Tags: Original article Source Type: research

Determinants of in-hospital muscle loss in acute ischemic stroke – Results of the Muscle Assessment in Stroke Study (MASS)
There is a change in the mass and composition of paretic and non-paretic skeletal muscles in the chronic phase of stroke. The multi-center, prospective, and observational Muscle Assessment in Stroke Study (MASS) was performed to evaluate the degree of muscle loss during the in-hospital acute stroke setting and determine factors contributing to this loss.
Source: Clinical Nutrition - February 1, 2023 Category: Nutrition Authors: Levent Gungor, Ethem Murat Arsava, Ayse Guler, Canan Togay Isikay, Ozlem Aykac, Hale Zeynep Batur Caglayan, Hasan Huseyin Kozak, Ustun Aydingoz, Mehmet Akif Topcuoglu Tags: Original article Source Type: research

Triglyceride-glucose index and short-term functional outcome and in-hospital mortality in patients with ischemic stroke
The triglyceride-glucose (TyG) index has been demonstrated as an independent marker of ischemic stroke. Whether TyG index predicts short-term outcomes in patients with ischemic stroke remains uncertain. The aim of the study was to investigate the early prognosis value of TyG index in ischemic stroke patients.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - November 7, 2022 Category: Nutrition Authors: Mengyuan Miao, Yucong Bi, Lijun Hao, Anran Bao, Yaming Sun, Huaping Du, Liyan Song, Shoujiang You, Chongke Zhong Source Type: research

Combined prognostic significance of white blood cell count and D-dimer on in-hospital outcomes of acute ischemic stroke
The prognostic significance of combination of white blood cell (WBC) and D-dimer on acute ischemic stroke (AIS) remains to be explored. We aimed to investigate the combined effect of WBC and D-dimer levels on in-hospital outcomes of AIS patients.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 19, 2022 Category: Nutrition Authors: Dan Peng, Yaqian Huang, Yi Wang, Zhichao Huang, Yafang Zhu, Rongfang Shi, Yongrong Sun, Yan Qin, Yongjun Cao, Xia Zhang Source Type: research

Iron Metabolism and Brain Development in Premature Infants
Yafeng Wang1,2,3, Yanan Wu2, Tao Li1,2,3, Xiaoyang Wang2,4 and Changlian Zhu2,3* 1Department of Neonatology (NICU), Children’s Hospital Affiliated Zhengzhou University, Zhengzhou, China 2Henan Key Laboratory of Child Brain Injury, Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China 3Department of Clinical Neuroscience, Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden 4Department of Physiology, Sahlgrenska Academy, Institute of Neuroscience and Physiology, University of Got...
Source: Frontiers in Physiology - April 24, 2019 Category: Physiology Source Type: research

Childhood arterial ischemic stroke in Senegal (West Africa).
Abstract Etiological factors of childhood ischemic stroke depend on the epidemiological context. The purpose of this study was to determine the risk factors, the clinical and radiologic features, and the outcome of arterial ischemic stroke in a case series of Senegalese children. We carried out a retrospective registry-based study on arterial ischemic stroke in children hospitalized in the neurology department of Fann Teaching Hospital and Albert Royer Children's Hospital, from January 2005 to December 2015. We enrolled 116 cases with an age range from 2 months to 18 years. The mean age at stroke occurrence was 71...
Source: Archives de Pediatrie - August 21, 2018 Category: Pediatrics Authors: Ndiaye M, Lengue F, Sagna SD, Sow AD, Fogany Y, Deme H, Basse AM, Diop-Sene MS, Diagne NS, Diop AG, Ndiaye O, Ndiaye MM Tags: Arch Pediatr Source Type: research

Post ‐stroke hypertension control and receipt of health care services among veterans
Many ischemic stroke patients do not achieve goal blood pressure (BP < 140/90 mm Hg). To identify barriers to post‐stroke hypertension management, we examined healthcare utilization and BP control in the year after index ischemic stroke admission. This retrospective cohort study included patients admitted for acute ischemic stroke to a VA hospital in fiscal year 2011 and who were discharged with a BP ≥ 140/90 mm Hg. One‐year post‐discharge, BP trajectories, utilization of primary care, specialty and ancillary services were studied. Among 265 patients, 246 (92.8%) were seen by primary care (PC) during the 1...
Source: The Journal of Clinical Hypertension - February 4, 2018 Category: Cardiology Authors: Dhanashri D. Kohok, Jason J. Sico, Fitsum Baye, Laura Myers, Jessica Coffing, Masoor Kamalesh, Dawn M. Bravata Tags: ORIGINAL PAPER Source Type: research