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Diane Stephenson, Ph.D.
EVP, Coalition Against Major DiseasesDiane Stephenson is a neuroscientist by training with 30 years  combined experience in academic neuroscience and drug discovery.  She is passionate about translational science and has a long time  dedication to the discovery of therapies to treat diseases of the nervous system. Diane received her undergraduate degree in Biochemistry at University of California, Santa Barbara and her Ph.D. in Medical Neurobiology from Indiana University. In her academic career, Diane focused her research on Amyotrophic Lateral Sclerosis and Alzheimer's disease while in industry she focused on drug dis...
Source: PHRMA - November 5, 2013 Category: Pharmaceuticals Authors: Leah Source Type: news

Diane Stephenson
is a neuroscientist by training with 30 years  combined experience in academic neuroscience and drug discovery.  She is passionate about translational science and has a long time  dedication to the discovery of therapies to treat diseases of the nervous system. Diane received her undergraduate degree in Biochemistry at University of California, Santa Barbara and her Ph.D. in Medical Neurobiology from Indiana University. In her academic career, Diane focused her research on Amyotrophic Lateral Sclerosis and Alzheimer's disease while in industry she focused on drug discovery for Alzheimer's disease, stroke and Parkinson'...
Source: PHRMA - November 5, 2013 Category: Pharmaceuticals Authors: Leah Source Type: news

Personalizing Anticoagulant and Antiplatelet Therapeutics: A Timely Task
Abstract In spite of new therapeutics and diagnostics, thrombosis‐related diseases including heart failure and stroke remain the leading cause of death globally and a major healthcare burden. Pharmacogenomic studies may reduce the burden of thrombotic diseases by aiding treatment individualization with the most appropriate anti‐coagulant and anti‐platelet therapeutics. Discovering and validating biomarkers for improved personalized treatment of thrombotic diseases will require massive investment. A concerted dedicated effort built upon a public‐private partnership is warranted for addressing this foremost public health concern.
Source: Drug Development Research - October 21, 2013 Category: Drugs & Pharmacology Authors: David Gurwitz Tags: Editorial Source Type: research

UCLA, USC get $2M to develop stroke center network in Southland
Stroke is the second leading cause of death in Los Angeles County and the fourth in the U.S. In order to cut those numbers, it's imperative that new treatments be developed and refined for stroke prevention, acute therapy and recovery after stroke.   Now, a three-way partnership between the UCLA Stroke Center at Ronald Reagan UCLA Medical Center, the USC Comprehensive Stroke and Cerebrovascular Center at Keck Medicine of USC, and UC Irvine has been awarded a $2 million grant from the National Institutes of Health to address these three stroke priorities.   Together, the three universities will form the Los A...
Source: UCLA Newsroom: Health Sciences - October 15, 2013 Category: Universities & Medical Training Source Type: news

Walking ‘could save 37,000 lives a year’ report claims
The benefits of walking have been reported across the UK media. The BBC reports that “walking more 'would save thousands' of lives in the UK”. These stories have been prompted by the "Walking Works” report (PDF, 3.4MB). It provides an overview of current evidence on physical inactivity, and makes the case for encouraging more people to take up walking as a form of physical activity. It lays out that a large proportion of the population is not meeting physical activity guidelines and that if more people did so, this could potentially save 37,000 lives a year in England. It also discusses the specific benefits o...
Source: NHS News Feed - October 7, 2013 Category: Consumer Health News Tags: Cancer Lifestyle/exercise QA articles Source Type: news

Risk Of Stroke Effectively Reduced By Simple 2-Drug Combination
Results of a Phase III clinical trial showed that a simple drug regimen of two anti-clotting drugs - clopidogrel and aspirin- lowered the risk of stroke by almost one-third, compared to the standard therapy of aspirin alone, when given to patients who had minor or transient stroke symptoms to prevent subsequent attacks. Described this week in the New England Journal of Medicine (July 4, 2013 print issue), the clinical trial was conducted at multiple sites in China and designed in partnership with a physician at UC San Francisco...
Source: Health News from Medical News Today - June 28, 2013 Category: Consumer Health News Tags: Stroke Source Type: news

Drug Combo Cuts Stroke Risk After TIA
A simple combination of two anti-clotting drugs, clopidogrel and aspirin, can cut the risk of a stroke in patients who have already experienced a mini-stroke or transient ischemic attack (TIA). This was the result of a phase 3 clinical trial conducted in China with the help of a US physician who says it could change the standard of care in the US. The investigators report their findings in the 26 June online issue of the New England Journal of Medicine, NEJM. The trial took place at several sites in China and was designed in partnership with S...
Source: Health News from Medical News Today - June 27, 2013 Category: Consumer Health News Tags: Stroke Source Type: news

Timely treatment after stroke is crucial, UCLA researchers report
For years, the mantra of neurologists treating stroke victims has been "time equals brain." That's because getting a patient to the emergency room quickly to receive a drug that dissolves the stroke-causing blood clot can make a significant difference in how much brain tissue is saved or lost.   But specific information has been limited on just how the timing of giving the intravenous drug — known as a tissue plasminogen activator, or tPA — influences outcomes for victims of ischemic (clot-caused), stroke, the most common type of stroke.   Now, a team led by UCLA researchers has conducted a major stud...
Source: UCLA Newsroom: Health Sciences - June 18, 2013 Category: Universities & Medical Training Source Type: news

UCLA, partners get $11M to develop stroke-prevention programs for minority populations
UCLA researchers and their partners across Los Angeles County have been awarded an $11 million federal grant to fund research on community-based interventions aimed at reducing the higher rates of stroke and death from stroke among disadvantaged Hispanics, African Americans and Asian Americans.   Research has shown that stroke risk can be substantially lowered by increasing physical activity, controlling blood pressure, adopting a healthy diet, quitting smoking, lowering cholesterol and, for certain individuals, taking medication like aspirin.   However, the underserved populations targeted by this research progr...
Source: UCLA Newsroom: Health Sciences - May 1, 2013 Category: Universities & Medical Training Source Type: news

Lipid Abnormalities in Foreign and US-Born Patients in a Medical Group
This study was funded by the HealthPartners Research Foundation (a partnership grant to TEK); The Heart Disease and Stroke Prevention Unit at the Minnesota Department of Health from a Capacity Building - Cooperative Agreement grant from the Centers for Disease Control and Prevention CDC) 5U50DP000721-04; and NIH training grant T32 HL69764 (supporting CJB).
Source: Journal of Clinical Lipidology - May 1, 2013 Category: Lipidology Authors: Jawali Jaranilla, Teri Defor, Gabriella Vasquez Benitez, Thomas Kottke Tags: Abstracts Source Type: research

Between the Lines: Generating Good Qualitative Data in Studies Involving Persons With Aphasia
High-quality data are essential for developing knowledge in qualitative inquiries. Language impairments affect the ability to meet the requirements that constitute good qualitative data. In this article, we focus on generating good qualitative data in persons with aphasia following stroke. We drew on experiences from a longitudinal nursing intervention to discuss how to maximize data generation in accordance with norms for data quality in this population. The longitudinal design, using a combination of research methods, and the iterative process of data generation and analysis over time constituted a continuity that enhanc...
Source: Advances in Nursing Science - April 1, 2013 Category: Nursing Tags: Original Articles Source Type: research

Online training and brochure for stroke care teams launched
Source: Wessex HIEC Partnership Area: News Wessex HIEC in collaboration with the University of Central Lancashire has launched an online training package for professionals involved in stroke care. The clinical leads forum has also developed a brochure for patients and their families to understand more about the condition and information specific to their own care.   Please see link for details.
Source: NeLM - News - February 19, 2013 Category: Drugs & Pharmacology Source Type: news

The Sur1-Trpm4 Channel Molecular Bases of Disease
The sulfonylurea receptor 1 (Sur1)-NCCa-ATP channel plays a central role in necrotic cell death in central nervous system (CNS) injury, including ischemic stroke, and traumatic brain and spinal cord injury. Here, we show that Sur1-NCCa-ATP channels are formed by co-assembly of Sur1 and transient receptor potential melastatin 4 (Trpm4). Co-expression of Sur1 and Trpm4 yielded Sur1-Trpm4 heteromers, as shown in experiments with Förster resonance energy transfer (FRET) and co-immunoprecipitation. Co-expression of Sur1 and Trpm4 also yielded functional Sur1-Trpm4 channels with biophysical properties of Trpm4 and pharmacologic...
Source: Journal of Biological Chemistry - February 1, 2013 Category: Chemistry Authors: Woo, S. K., Kwon, M. S., Ivanov, A., Gerzanich, V., Simard, J. M. Tags: Membrane Biology Source Type: research

Partnerships Can Fight Childhood Obesity in Tennessee (Opinion)
America has a weight problem — and I’m not simply referring to the few extra pounds many of us pick up over the holidays. According to the Centers for Disease Control and Prevention, nearly 70 percent of Americans are either overweight or obese, and our wide waistlines put us at greater risk for life-threatening health conditions such as heart disease, stroke, type 2 diabetes and several types of cancer. Unfortunately, Tennesseans fare worse than most.
Source: RWJF News Digest - Childhood Obesity - January 25, 2013 Category: Eating Disorders and Weight Management Source Type: news