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Neurosyphilis with positive anti-N-methyl-D-aspartate receptor antibody: a case report
A case of neurosyphilis with a positive anti-N-methyl-D-aspartate receptor (NMDAR) antibody was reported. A 54-year-old man who presented with acute memory deficits was admitted to our hospital. Acute ischemic stroke (AIS) was initially considered, and he was prescribed intravenous thrombolysis with recombinant tissue-type plasminogen activator (rt-PA). However, the intermittent onset of episodic memory and orientation disorder still occurred. No diffusion restriction was indicated by magnetic resonance imaging (MRI), and subclinical seizures were frequently found by electroencephalogram (EEG). Rapid plasma reagin (RPR) te...
Source: Frontiers in Neurology - May 18, 2023 Category: Neurology Source Type: research

Acute stroke during penicillin desensitization due to jarisch herxheimer
Jarisch Herxheimer reaction (JHR) is a transient episode seen within 24 hours of treatment with antibiotics in patients infected by spirochetes. Although seen in 95% of patients, it occurs rarely in late or latent syphilis. The severity depends on the spirochete load.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: S. Bhatti, J. Deluca, J. McCracken Tags: M060 Source Type: research

Cerebral venous thrombosis revealing neurosyphilis
CONCLUSION: Cerebral venous thrombosis in neurosyphilis is a poorly described entity. This case report confirms the status of great simulator of syphilis. In the context of its worldwide recrudescence, syphilis must be evoked in front of an unexplained neurological disorder.PMID:34863597 | DOI:10.1016/j.revmed.2021.11.001
Source: Revue de Medecine Interne - December 5, 2021 Category: Internal Medicine Authors: O Chol S Gallet L Bouillet G Besson H Kholi Source Type: research

Stroke and syphilis: A retrospective study of 53 patients.
CONCLUSION: A diagnosis of syphilitic stroke should be suspected in young patients as a manifestation of syphilis, and tests for neurosyphilis should be routine in neurology departments to make a prompt diagnosis, thereby preventing psychological sequelae. PMID: 29631855 [PubMed - as supplied by publisher]
Source: Revue Neurologique - April 12, 2018 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

One night with venus, a lifetime with mars
I present a case of neurosyphilis presenting as acute stroke in a 44-year-old male; I review the current literature, with a particular emphasis on diagnostics and the pitfalls of serological testing. Neurosyphilis is an imprecise term and subsumes meningitic, meningovascular, parenchymatous and gummatous syphilis. Of these, meningovascular syphilis is most commonly associated with large vessel arteritis and stroke, particularly of the middle cerebral artery. Although syphilis rates have increased since the latter part of the 20th century, neurosyphilis remains a rare disease and epidemiological estimates are marred by impr...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Johnson, J. Tags: Abstracts Source Type: research