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Specialty: Drugs & Pharmacology
Infectious Disease: SARS
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Total 23 results found since Jan 2013.
Neurological consequences of COVID-19
Pharmacol Rep. 2022 Sep 30. doi: 10.1007/s43440-022-00424-6. Online ahead of print.ABSTRACTIn December 2019, cases of pneumonia caused by infection with the previously unknown severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), leading to coronavirus disease 2019 (COVID-19), were identified. Typical manifestations of COVID-19 are fever, cough, fatigue and dyspnoea. Initially, it was thought that the mechanism of action of SARS-CoV-2 was only associated with respiratory tract invasion, but it was later revealed that the infection might involve many other organs and systems, including the central and peripheral ner...
Source: Pharmacological Reports - September 30, 2022 Category: Drugs & Pharmacology Authors: Waldemar Brola Maciej Wilski Source Type: research
Cerebral microvascular complications associated with SARS-CoV-2 infection: How did it occur and how should it be treated?
Biomed Pharmacother. 2022 Aug 17;154:113534. doi: 10.1016/j.biopha.2022.113534. Online ahead of print.ABSTRACTCerebral microvascular disease has been reported as a central feature of the neurological disorders in patients with SARS-CoV-2 infection that may be associated with an increased risk of ischemic stroke. The main pathomechanism in the development of cerebrovascular injury due to SARS-CoV-2 infection can be a consequence of endothelial cell dysfunction as a structural part of the blood-brain barrier (BBB), which may be accompanied by increased inflammatory response and thrombocytopenia along with blood coagulation d...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 22, 2022 Category: Drugs & Pharmacology Authors: Neda Omidian Pantea Mohammadi Mona Sadeghalvad Hamid-Reza Mohammadi-Motlagh Source Type: research
Role of the renin-angiotensin system in NETosis in the coronavirus disease 2019 (COVID-19)
Biomed Pharmacother. 2022 Feb 14;148:112718. doi: 10.1016/j.biopha.2022.112718. Online ahead of print.ABSTRACTMyocardial infarction and stroke are the leading causes of death in the world. Numerous evidence has confirmed that hypertension promotes thrombosis and induces myocardial infarction and stroke. Recent findings reveal that neutrophil extracellular traps (NETs) are involved in the induction of myocardial infarction and stroke. Meanwhile, patients with severe COVID-19 suffer from complications such as myocardial infarction and stroke with pathological signs of NETs. Due to the extremely low amount of virus detected i...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 17, 2022 Category: Drugs & Pharmacology Authors: Qingguang Zhang Shang Ling Kaili Hu Jun Liu Jin-Wen Xu Source Type: research
Mini-Review on SARS-CoV-2 Infection and Neurological Manifestations: A Perspective
CNS Neurol Disord Drug Targets. 2021 Jul 6. doi: 10.2174/1871527320666210706103422. Online ahead of print.ABSTRACTThe coronavirus, also known as SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus-19), with its rapid rate of transmission, has progressed with a great impact on respiratory function and mortality worldwide. The nasal cavity is the promising gateway of SARS-CoV-2 to reach the brain via systemic circulatory distribution. Recent reports have revealed that the loss of involuntary process of breathing control into the brainstem that results in death is a signal of neurological involvement. Early neurologica...
Source: CNS and Neurological Disorders Drug Targets - December 30, 2021 Category: Drugs & Pharmacology Authors: Vishal Chavda Arif Tasleem Jan Dhananjay Yadav Source Type: research
Network Meta-analysis on the Changes of Amyloid Precursor Protein Expression Following SARS-CoV-2 Infection
AbstractSARS-CoV-2 infection begins with the attachment of its spike (S) protein to angiotensin-converting enzyme-2 (ACE2) followed by complex host immune responses with cardiovascular and neurological implications. Our meta-analyses used QIAGEN Ingenuity Pathway Analysis (IPA) and Knowledge Base (QKB) to investigate how the expression of amyloid precursor protein (APP) was modulated by attachment of SARS-CoV-2 S protein in the brain microvascular endothelial cells (BMVECs) and during COVID-19 in progress. Published 80 host response genes reported to be modulated in BMVECs following SARS-CoV-2 S protein binding were used t...
Source: Journal of NeuroImmune Pharmacology - November 10, 2021 Category: Drugs & Pharmacology Source Type: research
A mini-review on the impact of COVID 19 on vital organs
Biomed Pharmacother. 2021 Sep 4;143:112158. doi: 10.1016/j.biopha.2021.112158. Online ahead of print.ABSTRACTCOVID-19 (Corona Virus Disease-2019) is an infectious disease caused by a novel coronavirus, known as the acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This is a highly contagious disease that has already affected more than 220 countries globally, infecting more than 212 million people and resulting in the death of over 4.4 million people. This review aims to highlight the pertinent documentary evidence upon the adverse effects of the SARS-CoV-2 infection on several vital human organs. SARS-CoV-2 primarily ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 10, 2021 Category: Drugs & Pharmacology Authors: Muhammad Dawood Shah Aini Simon Sumeh Muhammad Sheraz Muthu Subash Kavitha Balu Alagar Venmathi Maran Kenneth Francis Rodrigues Source Type: research
Identification of Novel Gene Signatures using Next-Generation Sequencing Data from COVID-19 Infection Models: Focus on Neuro-COVID and Potential Therapeutics
In conclusion, our study unravels a rapid approach for applying next-generation knowledge discovery (NGKD) platforms to discover small molecules with therapeutic potential against COVID-19 and its related disease pathologies.
Source: Frontiers in Pharmacology - August 31, 2021 Category: Drugs & Pharmacology Source Type: research
Adverse Cardiovascular Effects of Anti-COVID-19 Drugs
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or COVID-19 infection is the cause of the ongoing global pandemic. Mortality from COVID-19 infection is particularly high in patients with cardiovascular diseases. In addition, COVID-19 patients with preexisting cardiovascular comorbidities have a higher risk of death. Main cardiovascular complications of COVID-19 are myocardial infarction, myocarditis, acute myocardial injury, arrhythmias, heart failure, stroke, and venous thromboembolism. Therapeutic interventions in terms of drugs for COVID-19 have many cardiac adverse effects. Here, we review the relative the...
Source: Frontiers in Pharmacology - August 25, 2021 Category: Drugs & Pharmacology Source Type: research
COVID-19 preparedness: Clinical pharmacy services remote staffing in a quaternary, level I trauma and comprehensive stroke center
CONCLUSION: The proactive measures described can help ensure that pharmacy caregivers have appropriate remote access and are capable of confidently using the resources. These steps allow for optimal care of hospitalized patients and promote social distancing, which may have the added benefit of decreasing the spread of SARS-CoV-2 among patients and caregivers.PMID:34286818 | PMC:PMC7239242 | DOI:10.1093/ajhp/zxaa132
Source: American Journal of Health-System Pharmacy : AJHP - July 21, 2021 Category: Drugs & Pharmacology Authors: Sara Kjerengtroen Samuel M Wilde Gabriel V Fontaine Kevin M Forbush Charles M Van Gorder Paul Wohlt Source Type: research
