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Cross-Reactivity as a Mechanism Linking Infections to Stroke
The relevance of infections as risk factor for cerebrovascular disease is being increasingly recognized. Nonetheless, the pathogenic link between the two entities remains poorly understood. Consistent with recent advances in medicine, the present work addresses the hypothesis that infection-induced immune responses may affect human proteins associated with stroke. Applying established procedures in bioinformatics, the pathogen antigens and the human proteins were searched for common sequences using pentapeptides as probes. The data reported demonstrate massive peptide sharing between infectious pathogens—such as Chlamydi...
Source: Frontiers in Neurology - May 13, 2019 Category: Neurology Source Type: research

Pivotal pathogenic and biomarker role of Chlamydia Pneumoniae in neurovascular diseases.
Abstract Chlamydia pneumoniae(C.Pn) is an obligatory intracellular bacterium that is associated with respiratory tract infections like pneumonia, pharyngitis and bronchitis. It has also been implicated in cerebrovascular (stroke) as well as cardiovascular diseases. The most possible pathway via which C.Pn elicits its pathogenesis could be via activation of human vascular smooth muscle cells (VSMCs) proliferation resulting in the stimulation of toll like receptor-4 (TLR-4) and/or phospho-44/42(p44/p42) mitogen-activated protein kinases (MAPK). It is also established that tyrosine phosphorylation of IQ domain GTPase...
Source: Current Neurovascular Research - July 17, 2018 Category: Neurology Authors: Richard SA Tags: Curr Neurovasc Res Source Type: research

Infections and Chlamydia pneumoniae antibodies influence the functional outcome in thrombolysed strokes
Thrombolysis is effective in ischemic stroke patients, but some factors influence its benefit. Previous infections could increase the risk of ischemic stroke by an activation of systemic inflammation. We analysed the influence of previous infections and Chlamydia pneumoniae serology on functional outcome in thrombolysed stroke patients. Methods: Consecutive thrombolysed stroke patients admitted during calendar year 2011 were analysed. Demographics, vascular risk factors, clinical and aetiological data were registered.
Source: Journal of the Neurological Sciences - August 2, 2017 Category: Neurology Authors: Domenico Consoli, Simone Vidale, Marco Arnaboldi, Anna Cavallini, Arturo Consoli, Franco Galati, Donata Guidetti, Giuseppe Micieli, Maurizia Rasura, Roberto Sterzi, Danilo Toni, Domenico Inzitari Source Type: research

Novel Inflammatory Biomarkers and Their Correlation to Chlamydia pneumoniae Titres in Acute Ischemic Stroke
Conclusions: The study demonstrated high levels of hsp 65 and neopterin levels in AIS correlated to significantly elevated IgA titres of C pneumoniae. Elevated levels of hsp 65 were associated with stroke severity.
Source: Journal of Stroke and Cerebrovascular Diseases - September 29, 2014 Category: Neurology Authors: M.V. Padma Srivastava, Ashu Bhasin, Rama Chaudhry, Sakshi Sharma, Vivekanandhan Subbaiah, Rohit Bhatia, Manjari Tripathi Tags: Original Articles Source Type: research

Chlamydia pneumoniae infection and cerebral infarction risk: a meta‐analysis
Conclusion(1) This meta‐analysis indicated that C. pneumoniae infection was significantly associated with an increased risk of cerebral infarction. (2) Compared with anti‐C. pneumoniae immunoglobulin G, anti‐C. pneumoniae immunoglobulin A seemed more effective for predicting the risk of cerebral infarction. (3) No evidence existed that anti‐C. pneumoniae‐immunoglobulin G detected by enzyme‐linked immunosorbent assay could predict the risk of cerebral infarction.
Source: International Journal of Stroke - March 5, 2014 Category: Neurology Authors: Xing Su, Hong‐Lin Chen Tags: Systematic review Source Type: research

Chlamydia pneumoniae infection and cerebrovascular disease: a systematic review and meta-analysis
Conclusion: Association between C.pneumoniae infection and CV disease depends on the analytical method adopted, which seems stronger with stroke due to large artery atherosclerosis. Establishing a causal relationship between C.peumoniae infection and CV disease will require more prospective studies with combination of techniques and stratified by etiological subtypes.
Source: BMC Neurology - November 21, 2013 Category: Neurology Authors: Juan ChenMeijia ZhuGaoting MaZhangning ZhaoZhongwen Sun Source Type: research

Infectious burden and cognitive function: The Northern Manhattan Study
Conclusion: A measure of IB associated with stroke risk and atherosclerosis was independently associated with cognitive performance in this multiethnic cohort. Past infections may contribute to cognitive impairment.
Source: Neurology - March 25, 2013 Category: Neurology Authors: Katan, M., Moon, Y. P., Paik, M. C., Sacco, R. L., Wright, C. B., Elkind, M. S. V. Tags: All Infections, All Cerebrovascular disease/Stroke, All Cognitive Disorders/Dementia ARTICLE Source Type: research