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Chagas Disease and Stroke: Frequency and Clinical Correlates (P3.235)
Conclusions: Patients presenting with stroke and CD had more cardiac impairment and cardioembolic events than non-CD patients. Better healthcare of stroke patients and CD is required as these patients were readmitted more frequently than those without CDDisclosure: Dr. Meira has nothing to disclose. Dr. Teixeira has nothing to disclose. Dr. Nunes has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Meira, F., Teixeira, A., Nunes, M. d. C. Tags: Stroke in the Young Source Type: research

Stroke in Chagas disease: from pathophysiology to clinical practice
Rev Soc Bras Med Trop. 2022 Jun 6;55:e0575. doi: 10.1590/0037-8682-0575-2021. eCollection 2022.ABSTRACTDespite substantial progress toward its control, Chagas disease continues to be a major public health problem in Latin America and has become a global health concern. The disease affects approximately 6 million people, of whom 20-40% will develop cardiomyopathy over the years after the initial Trypanosoma cruzi infection. Chagas cardiomyopathy is the most serious and frequent manifestation of Chagas disease. Clinical manifestations vary widely according to the severity of myocardial dysfunction, ranging from asymptomatic ...
Source: Atherosclerosis - June 8, 2022 Category: Cardiology Authors: Tha ís Aparecida Reis Lage Julia Teixeira Tupinamb ás Lucas Bretas de P ádua Matheus de Oliveira Ferreira Amanda Cambraia Ferreira Antonio Lucio Teixeira Maria Carmo Pereira Nunes Source Type: research

Chagas’ cardiomyopathy is associated with higher incidence of stroke: a meta-analysis of observational studies
Chagas’ disease (CD) has been associated with an elevated risk of stroke, but current data are conflicting and prospective controlled studies are lacking. We performed a systematic review and meta-analysis examining the association between stroke and CD.
Source: Journal of Cardiac Failure - September 14, 2014 Category: Cardiology Authors: Rhanderson N. Cardoso, Francisco Yuri B. Macedo, Melissa Nolan Garcia, Daniel C. Garcia, Alexandre M. Benjo, David Aguilar, Hani Jneid, Biykem Bozkurt Tags: Clinical Investigations Source Type: research

Chagas Cardiomyopathy is Associated With Higher Incidence of Stroke: A Meta-analysis of Observational Studies
Chagas disease (CD) has been associated with an elevated risk of stroke, but current data are conflicting and prospective controlled studies are lacking. We performed a systematic review and meta-analysis examining the association between stroke and CD.
Source: Journal of Cardiac Failure - September 14, 2014 Category: Cardiology Authors: Rhanderson N. Cardoso, Francisco Yuri B. Macedo, Melissa Nolan Garcia, Daniel C. Garcia, Alexandre M. Benjo, David Aguilar, Hani Jneid, Biykem Bozkurt Tags: Clinical Investigation Source Type: research

Anticoagulation in patients with cardiac manifestations of Chagas disease and cardioembolic ischemic stroke
Conclusion Patients with Chagas disease an d previous CIS had better control of INR with a higher frequency of minor bleeding.RESUMO Objetivos descrever as caracter ísticas da anticoagulação em pacientes com manifestações cardíacas da doença de Chagas (MCDC) e comparar os participantes com sem acidente vascular cerebral isquêmico cardioembólico (AVCIC). Resultados 42 pacientes com MCDC em anticoagulação foram estudados (62,9 ± 12,4 anos), 59,5% do sexo feminino e 47,6% com AVCIC prévio, 78,6% portadores de fibrilação atrial não valvar e 69,7% com cardiomiopatia dilatada. Varfarina foi utilizada em 78,6% dos...
Source: Arquivos de Neuro-Psiquiatria - January 22, 2018 Category: Neurology Source Type: research

Multiple Strokes in a Latin American Patient
We present a case of a recent immigrant from El Salvador without past medical history who presented to our hospital with symptoms concerning for acute stroke. Brain magnetic resonance imaging (MRI) with gadolinium confirmed an acute stroke along with multiple prior infarcts involving different vascular beds. Head magnetic resonance arteriogram did not reveal any occlusions/stenosis or aneurysmal changes. His subsequent extensive evaluation included an electrocardiogram (ECG) that revealed bifascicular block and echocardiography that suggested an apical aneurysm, but images were limited to assess. To further assess the like...
Source: Case Reports in Neurology - July 8, 2021 Category: Neurology Source Type: research

Tissue Inhibitor of Metalloproteinase-1 Is Increased in Chagasic Cardiomyopathy
Am J Trop Med Hyg. 2021 Jul 19:tpmd200401. doi: 10.4269/ajtmh.20-0401. Online ahead of print.ABSTRACTChagas disease (CD) mainly conveys stroke risk through structural cardiac disease. However, stroke and cognitive impairment are seen in CD independently of cardiac disease severity. Chronic inflammation may be an explanation for this association, because inflammation plays an important role in the pathogenesis of acute ischemic stroke and dementia. In the present study, we selected five candidate biomarkers for Chagas disease: interleukin-6, membrane metalloproteinase-9, tissue inhibitor of metalloproteinase-1 (TIMP1), oros...
Source: The American Journal of Tropical Medicine and Hygiene - July 19, 2021 Category: Tropical Medicine Authors: Karina Oliveira Garcia Thiago Cerqueira Silva Maria do Carmo Pereira Nunes Iuri Ferreira Felix Murilo Araujo Oliveira Maria Eduarda Lisboa Marques Leila Souza Brito Santos Paulo Roberto Sampaio Peixoto Sousa Pedro Jos é Ramiro Muiños Renata Martins Maia Source Type: research

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