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Association between infection and carotid atherosclerosis in patients with vascular dementia
This study aimed to investigate the relationship between Hp infection and carotid atherosclerosis in patients with VD.
Source: Journal of the Neurological Sciences - January 16, 2016 Category: Neurology Authors: Yuzhen Xu, Qian Wang, Yunlin Liu, Ruiting Cui, Kaili Lu, Yuwu Zhao Source Type: research

Evaluation of the risk of cardiovascular events with clarithromycin using both propensity score and self‐controlled study designs.
ConclusionsThere was some evidence for a short term association for first MI but none for a long term association for any outcome.
Source: British Journal of Clinical Pharmacology - April 19, 2016 Category: Drugs & Pharmacology Authors: Adrian A. Root, Angel Y. S. Wong, Yonas Ghebremichael‐Weldeselassie, Liam Smeeth, Krishnan Bhaskaran, Stephen J. W. Evans, Ruth Brauer, Ian Chi Kei Wong, Vidya Navaratnam, Ian Douglas Tags: Pharmacoepidemiology Source Type: research

Top 20 Research Studies of 2015 for Primary Care Physicians.
This article, the fifth installment in this annual series, summarizes the 20 POEMs based on original research studies judged to have the greatest clinical relevance for family physicians. Key recommendations include questioning the need for backup throat cultures; avoiding early imaging and not adding cyclobenzaprine or oxycodone to naproxen for patients with acute low back pain; and encouraging patients with chronic or recurrent low back pain to walk. Other studies showed that using a nicotine patch for more than eight weeks has little benefit; that exercise can prevent falls that cause injury in at-risk older women; and ...
Source: American Family Physician - April 30, 2016 Category: Primary Care Authors: Ebell MH, Grad R Tags: Am Fam Physician Source Type: research

Nonsteroidal Anti-inflammatory Drug and Aspirin-induced Peptic Ulcer Disease.
Abstract Despite decreasing Helicobacter pylori prevalence, the prevalence of peptic ulcer disease is increasing in the aged population, mainly due to increasing use of NSAIDs to manage pain and inflammation. In addition, low dose aspirin is employed as an anti-coagulant for those who have suffered or are at high risk of ischemic stroke and cardiovascular disease. However, NSAIDs and aspirin are injurious to mucosa of stomach and duodenum. NSAID-induced inhibition of mucosal prostaglandin synthesis is thought to be a major mechanism of gastrointestinal mucosal injury. The proportion of elderly has increased rapidl...
Source: Korean J Gastroenter... - June 19, 2016 Category: Gastroenterology Authors: Shim YK, Kim N Tags: Korean J Gastroenterol Source Type: research

Clinical Risk Factors for Gastroduodenal Ulcer in Romanian Low-Dose Aspirin Consumers.
Conclusions. Concomitant use of NSAIDs or anticoagulants, comorbidities (cerebrovascular disease), and male gender are the most important independent risk factors for ulcer on endoscopy in low-dose aspirin consumers, in a population with a high prevalence of H. pylori infection. PMID: 27579036 [PubMed]
Source: Gastroenterology Research and Practice - September 2, 2016 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Gastrointestinal bleeding in patients on novel oral anticoagulants: Risk, prevention and management.
Abstract Novel oral anticoagulants (NOACs), which include direct thrombin inhibitor (dabigatran) and direct factor Xa inhibitors (rivaroxaban, apixaban and edoxaban), are gaining popularity in the prevention of embolic stroke in non-valvular atrial fibrillation as well as in the prevention and treatment of venous thromboembolism. However, similar to traditional anticoagulants, NOACs have the side effects of bleeding, including gastrointestinal bleeding (GIB). Results from both randomized clinical trials and observations studies suggest that high-dose dabigatran (150 mg b.i.d), rivaroxaban and high-dose edoxaban (6...
Source: World Journal of Gastroenterology : WJG - March 21, 2017 Category: Gastroenterology Authors: Cheung KS, Leung WK Tags: World J Gastroenterol Source Type: research

Helicobacter pylori infection: old and new.
Authors: Diaconu S, Predescu A, Moldoveanu A, Pop CS, Fierbințeanu-Braticevici C Abstract Helicobacter pylori is a spiral-shaped bacterium that grows in the digestive tract and may be present in more than half of the world's population. The clinical features of Helicobacter pylori range from asymptomatic gastritis to gastrointestinal malignancy. Mucosa-associated lymphoid tissue (MALT) lymphoma is a low-grade B-cell marginal zone lymphoma and Helicobacter pylori has been detected in more than 75% of the patients with MALT lymphoma. Many tests for the detection of Helicobacter pylori are available, including antibo...
Source: Journal of Medicine and Life - June 17, 2017 Category: General Medicine Tags: J Med Life Source Type: research

Increased susceptibility of aging gastric mucosa to injury and delayed healing: Clinical implications.
Abstract In this editorial we comment on the article by Fukushi K et al published in the recent issue of the World Journal of Gastroenterology 2018; 24(34): 3908-3918. We focus specifically on the mechanisms of the anti-thrombotic action of aspirin, gastric mucosal injury and aging-related increased susceptibility of gastric mucosa to injury. Aspirin is widely used not only for the management of acute and chronic pain and arthritis, but also importantly for the primary and secondary prevention of cardiovascular events such as myocardial infarcts and strokes. Clinical trials have consistently shown that antiplatele...
Source: World Journal of Gastroenterology : WJG - November 14, 2018 Category: Gastroenterology Authors: Tarnawski AS, Ahluwalia A Tags: World J Gastroenterol Source Type: research

Infection and atherosclerosis: TLR-dependent pathways.
This article reviews the role of TLRs in the process of atherosclerosis after C. pneumoniae and other infections and the current status of treatment, with a view to providing a new direction and potential therapeutic targets for the study of ASVD. PMID: 32002588 [PubMed - as supplied by publisher]
Source: Cellular and Molecular Life Sciences : CMLS - January 29, 2020 Category: Cytology Authors: Li B, Xia Y, Hu B Tags: Cell Mol Life Sci Source Type: research

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