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Predictors of mortality and recurrent stroke within five years of intracerebral hemorrhage.
Conclusion Predictors of recurrent stroke were older females, hypertension, diabetes, and brain stem hemorrhage. These findings may help to determine specific treatment strategies and improve quality of health care for such patients. PMID: 30134784 [PubMed - in process]
Source: Neurological Research - August 25, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Risk factor profile in patients with stroke at a young age.
Conclusions Angiopathy is the most common risk factor for stroke at a young age. More than half of the patients with stroke at a young age have at least two independent risk factors for stroke. In the first two decades of life, the most frequent risk factors for stroke are heart diseases; arterial diseases play a dominant role in the consecutive three decades. PMID: 29577820 [PubMed - as supplied by publisher]
Source: Neurological Research - March 27, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Association of hemoglobin glycation index with outcomes of acute ischemic stroke in type 2 diabetic patients.
Conclusion Both low HGI and high HGI was associated with an increased risk of poor prognosis in diabetic patients with ischemic stroke, compared with moderate HGI. PMID: 29560815 [PubMed - as supplied by publisher]
Source: Neurological Research - March 23, 2018 Category: Neurology Tags: Neurol Res Source Type: research

A mini review: garlic extract and vascular diseases.
Authors: Zhu Y, Anand R, Geng X, Ding Y Abstract Vascular diseases refer to medical conditions that narrow blood vessels. Narrowed cardiac or cerebral arteries can lead to myocardial infarction or ischemic stroke. Risk factors including atherosclerosis, hypertension, and diabetes may induce either cardiovascular or cerebral complications. Based on current research, garlic favorably affects atherosclerosis, hypertension and diabetes, and helps decrease the risk of myocardial infarction and ischemic stroke. Garlic has been utilized for hundreds of years as a natural health remedy. New research is emerging regarding i...
Source: Neurological Research - March 23, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Genetic polymorphisms of vitamin D3 metabolizing CYP24A1 and CYP2R1 enzymes in Turkish patients with ischemic stroke.
Conclusion This is the first study conducted regarding the association of CYP24A1 rs927650 and CYP2R1 rs10741657 genetic polymorphisms and ischemic stroke risk. The polymorphic genotypes of these polymorphisms, together with hypertension, diabetes, smoking, and obesity, were found as significant risk factors for ischemic stroke. PMID: 29528271 [PubMed - as supplied by publisher]
Source: Neurological Research - March 14, 2018 Category: Neurology Tags: Neurol Res Source Type: research

A modified Essen Stroke Risk Score for predicting recurrent ischemic stroke at one year.
Conclusions The modified ESRS increased the ability of the original ESRS to predict recurrent stroke at one year among the Chinese population. PMID: 29369004 [PubMed - as supplied by publisher]
Source: Neurological Research - January 26, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Relationship of phosphodiesterase 4D (PDE4D) gene polymorphisms with risk of ischemic stroke: a hospital based case-control study.
CONCLUSION: SNP 83 of PDE4D gene may increase the risk for developing IS whereas SNP 87 and SNP45 of PDE4D may not be associated with the risk of IS in the North Indian population. Prospective cohort studies are required to corroborate these findings. PMID: 28562233 [PubMed - as supplied by publisher]
Source: Neurological Research - June 2, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Persistence of secondary prevention medication and related factors for acute ischemic stroke and transient ischemic attack in China.
CONCLUSIONS: More than half of patients with AIS and TIA reported discontinuing one or more secondary prevention medications within 3 months of hospital discharge. Several factors associated with medication persistence were identified. Here, we propose strategies that could be implemented to improve the quality of secondary prevention. PMID: 28420316 [PubMed - as supplied by publisher]
Source: Neurological Research - April 21, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Neuroprotective effect of ischemic preconditioning via modulating the expression of cerebral miRNAs against transient cerebral ischemia in diabetic rats.
In this study, we aimed to evaluate the effect of the Ischemic preconditioning (IPreC) on the expression profile of cerebral miRNAs against stroke by induced transient middle cerebral artery occlusion (MCAo) in diabetic rats. METHODS: Eighty male Spraque Dawley rats were allocated to eight groups. In order to evaluate the expression profile of miRNAs, we induced transient MCAo seven days after STZ-induced diabetes (DM). Also we performed IPreC 72 h before transient MCAo to assess whether IPreC could have a neuroprotective effect against ischemia-reperfusion injury. RESULTS: The general characteristics of STZ-treat...
Source: Neurological Research - September 18, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Association between serum cystatin C levels and the severity or potential risk factors of acute ischemic stroke.
CONCLUSION: Our study suggests that there is a close relationship between cystatin C and acute ischemic stroke, independently of conventional risk factors. But the levels of cystatin C are not correlated with the stroke severity. PMID: 27320246 [PubMed - in process]
Source: Neurological Research - June 21, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Association between Endothelial nitric oxide synthase G894T gene polymorphism and risk of ischemic stroke in North Indian population: a case-control study.
CONCLUSION: The findings of the present study suggest that polymorphism in G894T position of eNOS gene might be a risk factor for IS mainly for LVD stroke subtype in North Indian population. Further large prospective studies are required to confirm these findings. PMID: 27168380 [PubMed - as supplied by publisher]
Source: Neurological Research - May 18, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Association between interleukin-6 (G174C and C572G) promoter gene polymorphisms and risk of ischemic stroke in North Indian population: a case-control study.
CONCLUSION: Our results suggest that IL-6 (G174C) polymorphism is significantly associated with the risk of IS in North Indian population. However, IL-6 (C572G) polymorphism is found significantly associated with the risk of IS after adjusting the demographic and risk factors variables. Prospective studies with large sample size are required for independent validation. Our findings could be helpful in identifying individuals at increased risk for developing IS. PMID: 26883819 [PubMed - as supplied by publisher]
Source: Neurological Research - February 18, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Association between polyvascular atherosclerosis and estimated glomerular filtration rate in patients with ischaemic stroke: data analysis of the patients in the Chinese National Stroke Registry.
This study evaluated the prevalence of chronic kidney disease (CKD) in ischemic stroke (IS) patients with polyvascular disease (PolyVD) and analysed the relationship between PolyVD and estimated glomerular filtration rate (eGFR) in IS patients. METHODS: Data from 9152 consecutive IS patients from the China National Stroke Registry were analysed. PolyVD was defined as patients with IS and coronary artery disease (CAD) and/or peripheral arterial disease (PAD). Chronic kidney disease was defined as eGFR < 60 mL/minute/1.73 m(2).The prevalence of CKD in IS patients with PolyVD was calculated. Logistic regression w...
Source: Neurological Research - April 22, 2015 Category: Neurology Tags: Neurol Res Source Type: research

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