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Carotid Atherosclerosis and Cerebral Microbleeds: The Framingham Heart Study Epidemiology
Conclusions Cumulative vascular risk factor exposure may increase the risk of CMB, especially in deep regions. The apparent paradoxical association of carotid intima–media thickness progression with lower risk of CMB may reflect benefits of intensive vascular risk factor treatment among persons with higher cardiovascular risk and deserves further investigation. If replicated, the results may have potential implications for assessment of preventive and therapeutic interventions for subclinical cerebral hemorrhage.
Source: JAHA:Journal of the American Heart Association - March 17, 2016 Category: Cardiology Authors: Romero, J. R., Preis, S. R., Beiser, A., DeCarli, C., D'Agostino, R. B., Wolf, P. A., Vasan, R. S., Polak, J. F., Seshadri, S. Tags: Epidemiology, Magnetic Resonance Imaging (MRI), Ultrasound, Cerebrovascular Disease/Stroke, Atherosclerosis Source Type: research

Heart Rhythm Monitoring Strategies for Cryptogenic Stroke: 2015 Diagnostics and Monitoring Stroke Focus Group Report Special Reports
Source: JAHA:Journal of the American Heart Association - March 14, 2016 Category: Cardiology Authors: Albers, G. W., Bernstein, R. A., Brachmann, J., Camm, J., Easton, J. D., Fromm, P., Goto, S., Granger, C. B., Hohnloser, S. H., Hylek, E., Jaffer, A. K., Krieger, D. W., Passman, R., Pines, J. M., Reed, S. D., Rothwell, P. M., Kowey, P. R. Tags: Atrial Fibrillation, Secondary Prevention, Anticoagulants, Ischemic Stroke Special Reports Source Type: research

Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation: Data From ROCKET AF Arrhythmia and Electrophysiology
Conclusions In a large population of patients anticoagulated for nonvalvular atrial fibrillation, 7 in 10 deaths were cardiovascular, whereas <1 in 10 deaths were caused by nonhemorrhagic stroke or systemic embolism. Optimal prevention and treatment of heart failure, renal impairment, chronic obstructive pulmonary disease, and diabetes may improve survival. Clinical Trial Registration URL: https://www.clinicaltrials.gov/. Unique identifier: NCT00403767.
Source: JAHA:Journal of the American Heart Association - March 7, 2016 Category: Cardiology Authors: Pokorney, S. D., Piccini, J. P., Stevens, S. R., Patel, M. R., Pieper, K. S., Halperin, J. L., Breithardt, G., Singer, D. E., Hankey, G. J., Hacke, W., Becker, R. C., Berkowitz, S. D., Nessel, C. C., Mahaffey, K. W., Fox, K. A. A., Califf, R. M., for the Tags: Atrial Fibrillation, Sudden Cardiac Death, Heart Failure, Intracranial Hemorrhage, Ischemic Stroke Arrhythmia and Electrophysiology Source Type: research

Concomitant Use of Single Antiplatelet Therapy With Edoxaban or Warfarin in Patients With Atrial Fibrillation: Analysis From the ENGAGE AF-TIMI48 Trial Arrhythmia and Electrophysiology
Conclusions Patients with AF who were selected by their physicians to receive SAPT in addition to an anticoagulant had a similar risk of stroke/SEE and higher rates of bleeding than those not receiving SAPT. Edoxaban exhibited similar relative efficacy and reduced bleeding compared to warfarin, with or without concomitant SAPT. Clinical Trial Registration URL: http://www.clinicaltrials.gov/. Unique identifier: NCT00781391.
Source: JAHA:Journal of the American Heart Association - February 23, 2016 Category: Cardiology Authors: Xu, H., Ruff, C. T., Giugliano, R. P., Murphy, S. A., Nordio, F., Patel, I., Shi, M., Mercuri, M., Antman, E. M., Braunwald, E. Tags: Platelets, Chronic Ischemic Heart Disease, Anticoagulants, Acute Coronary Syndromes Arrhythmia and Electrophysiology Source Type: research

Ischemic Stroke in Children and Young Adults With Congenital Heart Disease Congenital Heart Disease
Conclusions The risk of developing ischemic stroke was almost 11 times higher in young patients with CHD than in the general population, although absolute risk is low. Cardiovascular comorbidities were strongly associated with the development of ischemic stroke in young CHD patients.
Source: JAHA:Journal of the American Heart Association - February 23, 2016 Category: Cardiology Authors: Mandalenakis, Z., Rosengren, A., Lappas, G., Eriksson, P., Hansson, P.-O., Dellborg, M. Tags: Epidemiology, Congenital Heart Disease, Ischemic Stroke Source Type: research

Effect of Adherence to Oral Anticoagulants on Risk of Stroke and Major Bleeding Among Patients With Atrial Fibrillation Arrhythmia and Electrophysiology
Conclusions Adherence to anticoagulation is poor in practice and may be modestly improved with NOACs. Adherence to therapy appears to be most important in patients with CHA2DS2-VASc score ≥2, whereas the benefits of anticoagulation may not outweigh the harms in patients with CHA2DS2-VASc score 0 or 1.
Source: JAHA:Journal of the American Heart Association - February 23, 2016 Category: Cardiology Authors: Yao, X., Abraham, N. S., Alexander, G. C., Crown, W., Montori, V. M., Sangaralingham, L. R., Gersh, B. J., Shah, N. D., Noseworthy, P. A. Tags: Arrhythmias, Atrial Fibrillation, Secondary Prevention, Intracranial Hemorrhage, Ischemic Stroke Arrhythmia and Electrophysiology Source Type: research

Population-Based Data on Congenital Heart Disease and Stroke Editorial
Source: JAHA:Journal of the American Heart Association - February 23, 2016 Category: Cardiology Authors: Opotowsky, A. R., Webb, G. D. Tags: Epidemiology, Congenital Heart Disease, Cerebrovascular Disease/Stroke, Ischemic Stroke Editorial Source Type: research

Persistence and Discontinuation of Oral Anticoagulant: Remaining Issues Not Addressed by Phase III Clinical Trials Editorial
Source: JAHA:Journal of the American Heart Association - February 23, 2016 Category: Cardiology Authors: Ayabe, K., Goto, S., Goto, S. Tags: Atrial Fibrillation, Quality and Outcomes, Ischemic Stroke Editorial Source Type: research

Population-Based Data on Congenital Heart Disease and Stroke Editorials
Source: JAHA:Journal of the American Heart Association - February 22, 2016 Category: Cardiology Authors: Opotowsky, A. R., Webb, G. D. Tags: Epidemiology, Congenital Heart Disease, Cerebrovascular Disease/Stroke, Ischemic Stroke Editorials Source Type: research

Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease Stroke
Conclusions A significant reduction of Ndufc2 expression causes complex I dysfunction and contributes to stroke susceptibility in SHRSP. Moreover, our current evidence may suggest that Ndufc2 can contribute to an increased occurrence of early-onset ischemic stroke in humans.
Source: JAHA:Journal of the American Heart Association - February 17, 2016 Category: Cardiology Authors: Rubattu, S., Di Castro, S., Schulz, H., Geurts, A. M., Cotugno, M., Bianchi, F., Maatz, H., Hummel, O., Falak, S., Stanzione, R., Marchitti, S., Scarpino, S., Giusti, B., Kura, A., Gensini, G. F., Peyvandi, F., Mannucci, P. M., Rasura, M., Sciarretta, S., Tags: Basic Science Research, Gene Expression & Regulation, Cerebrovascular Disease/Stroke Source Type: research

Rates of Atrial Fibrillation in Black Versus White Patients With Pacemakers Stroke
Conclusions In a population-based sample of patients with pacemakers, black patients had a lower rate of AF compared with white patients. These findings indicate that the persistent racial disparities in rates of ischemic stroke are likely to be related to factors other than undiagnosed AF.
Source: JAHA:Journal of the American Heart Association - February 12, 2016 Category: Cardiology Authors: Kamel, H., Kleindorfer, D. O., Bhave, P. D., Cushman, M., Levitan, E. B., Howard, G., Soliman, E. Z. Tags: Arrhythmias, Atrial Fibrillation, Epidemiology, Race and Ethnicity, Risk Factors Stroke Source Type: research

Pacemakers as Atrial Fibrillation Detectors: Finding Racial Differences and Opportunities for Preventing Stroke Editorial
Source: JAHA:Journal of the American Heart Association - February 12, 2016 Category: Cardiology Authors: Meschia, J. F. Tags: Atrial Fibrillation, Epidemiology, Race and Ethnicity, Genetics, Ischemic Stroke Editorial Source Type: research

Impact of an Emergency Department Observation Unit Management Algorithm for Atrial Fibrillation Arrhythmia and Electrophysiology
Conclusions Implementation of an emergency department observation unit AF algorithm was associated with significantly decreased hospital admissions without increasing the rates of return emergency department visits, hospitalization, or adverse events within 30 days.
Source: JAHA:Journal of the American Heart Association - February 8, 2016 Category: Cardiology Authors: Bellew, S. D., Bremer, M. L., Kopecky, S. L., Lohse, C. M., Munger, T. M., Robelia, P. M., Smars, P. A. Tags: Arrhythmias, Atrial Fibrillation, Cost-Effectiveness, Quality and Outcomes Arrhythmia and Electrophysiology Source Type: research

Stroke Severity Is a Crucial Predictor of Outcome: An International Prospective Validation Study Stroke
Conclusions In this prospective pilot study, the baseline NIHSS score was essential for prediction of acute ischemic stroke outcomes, followed by age; whereas traditional comorbidity index contributed little to the overall model. Future studies of stroke outcomes between different care systems will benefit from including a baseline NIHSS score.
Source: JAHA:Journal of the American Heart Association - January 21, 2016 Category: Cardiology Authors: Rost, N. S., Bottle, A., Lee, J.-M., Randall, M., Middleton, S., Shaw, L., Thijs, V., Rinkel, G. J. E., Hemmen, T. M., the Global Comparators Stroke GOAL collaborators Tags: Mortality/Survival, Quality and Outcomes, Cerebrovascular Disease/Stroke, Ischemic Stroke Source Type: research

Cardiac Time Intervals Measured by Tissue Doppler Imaging M-mode: Association With Hypertension, Left Ventricular Geometry, and Future Ischemic Cardiovascular Diseases Imaging
Conclusion The cardiac time intervals identify impaired cardiac function in individuals with hypertension, not only independent of conventional risk factors but also in participants with a normal conventional echocardiographic examination. The IVRT/ET and MPI are independent predictors of future cardiovascular disease especially in participants with known hypertension.
Source: JAHA:Journal of the American Heart Association - January 19, 2016 Category: Cardiology Authors: Biering-Sorensen, T., Mogelvang, R., Schnohr, P., Jensen, J. S. Tags: Risk Factors, Hypertension, Echocardiography, Quality and Outcomes, Ischemic Stroke Imaging Source Type: research

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