Stroke Severity Is a Crucial Predictor of Outcome: An International Prospective Validation Study Stroke

Conclusions In this prospective pilot study, the baseline NIHSS score was essential for prediction of acute ischemic stroke outcomes, followed by age; whereas traditional comorbidity index contributed little to the overall model. Future studies of stroke outcomes between different care systems will benefit from including a baseline NIHSS score.
Source: JAHA:Journal of the American Heart Association - Category: Cardiology Authors: Tags: Mortality/Survival, Quality and Outcomes, Cerebrovascular Disease/Stroke, Ischemic Stroke Source Type: research

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Condition:   Acute Ischemic Stroke Intervention:   Other: telephone call d90 Sponsor:   Xuanwu Hospital, Beijing Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Lipoxins (LXs) are generated from arachidonic acid and are involved in the resolution of inflammation and confer protection in a variety of pathological processes. In the nervous system, LXs exert an array of protective effects against neurological diseases, including ischemic or hemorrhagic stroke, neonatal hypoxia-ischemia encephalopathy, brain and spinal cord injury, Alzheimer’s disease, multiple sclerosis, and neuropathic pain. Lipoxin administration is a potential therapeutic strategy in neurological diseases due to its notable efficiency and unique superiority regarding safety. Here, we provide an overview of L...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conditions:   Stroke, Ischemic;   Stroke Hemorrhagic;   Spasticity, Muscle;   Spastic Gait Intervention:   Other: Radial extracorporeal shock wave therapy and conventional physical therapy Sponsor:   Carol Davila University of Medicine and Pharmacy Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractPurposeHere, we presented our early experience with flow diversion procedures using the Surpass Evolve flow diverter (SE, Stryker) and reported the feasibility and safety profile compared to those of a control group treated with other types of flow diverters.MethodsWe included 31 and 53 consecutive flow diversion procedures performed using the SE and other commercial flow diverters, respectively, to treat intracranial aneurysms at our institution. We used two commercial flow diversion systems in the comparison group: the pipeline embolization device and Surpass Streamline.ResultsIn the SE group, technical failures ...
Source: Neuroradiology - Category: Radiology Source Type: research
CONCLUSION: In an area with low to moderate air pollution exposure, we observed significant associations of long-term residential NOx with increased risk of incident CHF and fatal MI, but not with coronary events and stroke.PMID:35074356 | DOI:10.1016/j.envres.2022.112698
Source: Environmental Research - Category: Environmental Health Authors: Source Type: research
This study was aimed at exploring the molecular mechanism of CS using comprehensive bioinformatics analysis and providing new insights into the pathophysiology of CS. We downloaded the public datasets GSE58294 and GSE16561. Differentially expressed genes (DEGs) were screened via the limma package using R software. CIBERSORT was used to estimate the proportions of 22 immune cells based on the gene expression profiling of CS patients. Using weighted gene correlation network analysis (WGCNA) to cluster the genes into different modules and detect relationships between modules and immune cell types, hub genes were identified ba...
Source: Disease Markers - Category: Laboratory Medicine Authors: Source Type: research
The aim of the present study was to determine the neuroimaging predictors of poor participation after acute ischemic stroke. A total of 443 patients who had acute ischemic stroke were assessed. At 1-year recovery, the Reintegration to Normal Living Index was used to assess participation restriction. We also assessed the Activities of Daily Living Scale and modified Rankin Scale (mRS) score. Brain MRI measurement included acute infarcts and pre-existing abnormalities such as enlarged perivascular spaces, white matter lesions, ventricular-brain ratio, and medial temporal lobe atrophy (MTLA). The study included 324 men (73.1%...
Source: Journal of Investigative Medicine - Category: Research Authors: Tags: Open access Original research Source Type: research
Nature Reviews Neurology, Published online: 25 January 2022; doi:10.1038/s41582-021-00605-6In this Review, Fisher and Savitz consider how the era of reperfusion therapy in ischaemic stroke provides new hope for the development of cytoprotective therapies to further improve outcomes, highlighting how promising recent findings can be built on to benefit patients.
Source: Nature Reviews Neurology - Category: Neurology Authors: Source Type: research
This study aimed to propose a novel criterion for selecting the DOAC dose and investigate clinical characteristics of ischemic stroke (IS) under this criterion.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Source Type: research
This article was corrected online.
Source: JAMA - Category: General Medicine Source Type: research
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