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Incremental Prognostic Significance of the Elevated Levels of Pentraxin 3 in Patients With Heart Failure With Normal Left Ventricular Ejection Fraction Heart Failure
Conclusions High plasma PTX3 levels, but not other inflammatory markers, are correlated with future cardiovascular events in patients with HFNEF. PTX3 may be a useful biomarker for assessment of risk stratification in HFNEF. Clinical Trial Registration URL: http://www.umin.ac.jp; Unique identifier: UMIN000002170.
Source: JAHA:Journal of the American Heart Association - July 10, 2014 Category: Cardiology Authors: Matsubara, J., Sugiyama, S., Nozaki, T., Akiyama, E., Matsuzawa, Y., Kurokawa, H., Maeda, H., Fujisue, K., Sugamura, K., Yamamoto, E., Matsui, K., Jinnouchi, H., Ogawa, H. Tags: Heart Failure Source Type: research

Reduction in Overall Occurrences of Ischemic Events With Vorapaxar: Results From TRACER Coronary Heart Disease
Conclusions Vorapaxar reduced overall occurrences of ischemic events, but increased bleeding. These exploratory findings broaden our understanding of vorapaxar's potential and expand our understanding of the value of capturing recurrent events. Clinical Trial Registration URL: ClinicalTrials.gov. Unique identifier: NCT00527943.
Source: JAHA:Journal of the American Heart Association - July 10, 2014 Category: Cardiology Authors: White, H. D., Huang, Z., Tricoci, P., Van de Werf, F., Wallentin, L., Lokhnygina, Y., Moliterno, D. J., Aylward, P. E., Mahaffey, K. W., Armstrong, P. W. Tags: Coronary Heart Disease Source Type: research

Associations of Stressful Life Events and Social Strain With Incident Cardiovascular Disease in the Women's Health Initiative Epidemiology
Conclusions Higher SLE and social strain were associated with higher incident CVD independent of sociodemographic factors and depressive symptoms, but not behavioral and biological risk factors.
Source: JAHA:Journal of the American Heart Association - June 27, 2014 Category: Cardiology Authors: Kershaw, K. N., Brenes, G. A., Charles, L. E., Coday, M., Daviglus, M. L., Denburg, N. L., Kroenke, C. H., Safford, M. M., Savla, T., Tindle, H. A., Tinker, L. F., Van Horn, L. Tags: Epidemiology Source Type: research

The TeleStroke Mimic (TM)-Score: A Prediction Rule for Identifying Stroke Mimics Evaluated in a Telestroke Network Stroke
Conclusions SMs differ substantially from their iCVD counterparts in their vascular risk profiles and other characteristics. Decision-support tools based on predictive models, such as our TM Score, may help clinicians consider alternate diagnosis and potentially detect SMs during complex, time-critical telestroke evaluations.
Source: JAHA:Journal of the American Heart Association - June 23, 2014 Category: Cardiology Authors: Ali, S. F., Viswanathan, A., Singhal, A. B., Rost, N. S., Forducey, P. G., Davis, L. W., Schindler, J., Likosky, W., Schlegel, S., Solenski, N., Schwamm, L. H., on Behalf of Partners Telestroke Network Tags: Stroke Source Type: research

Patterns of Care Quality and Prognosis Among Hospitalized Ischemic Stroke Patients With Chronic Kidney Disease Health Services and Outcomes Research
Conclusions Despite higher in-hospital mortality rates, ischemic stroke patients with CKD, especially those with greater severity of renal dysfunction, were less likely to receive important guideline-recommended therapies.
Source: JAHA:Journal of the American Heart Association - June 5, 2014 Category: Cardiology Authors: Ovbiagele, B., Schwamm, L. H., Smith, E. E., Grau-Sepulveda, M. V., Saver, J. L., Bhatt, D. L., Hernandez, A. F., Peterson, E. D., Fonarow, G. C. Tags: Health Services and Outcomes Research Source Type: research

Cost-Effectiveness of Clopidogrel-Aspirin Versus Aspirin Alone for Acute Transient Ischemic Attack and Minor Stroke Stroke
Conclusions Early 90-day clopidogrel-aspirin regimen for acute TIA or minor stroke is highly cost-effective in China. Although clopidogrel is generic, Plavix is brand in China. If Plavix were generic, treatment with clopidogrel-aspirin would have been cost saving.
Source: JAHA:Journal of the American Heart Association - June 5, 2014 Category: Cardiology Authors: Pan, Y., Wang, A., Liu, G., Zhao, X., Meng, X., Zhao, K., Liu, L., Wang, C., Johnston, S. C., Wang, Y., Wang, Y., the CHANCE Investigators Tags: Stroke Source Type: research

Risk Factors Associated With Cerebrovascular Recurrence in Symptomatic Carotid Disease: A Comparative Study of Carotid Plaque Morphology, Microemboli Assessment and the European Carotid Surgery Trial Risk Model Stroke
Conclusions The presence of carotid plaque hemorrhage is better associated with recurrent cerebrovascular events in patients with symptomatic severe carotid stenosis than the presence of microembolic signals; combining MES and MRIPH, further improves the association while the ECST risk score was insignificant.
Source: JAHA:Journal of the American Heart Association - June 3, 2014 Category: Cardiology Authors: Altaf, N., Kandiyil, N., Hosseini, A., Mehta, R., MacSweeney, S., Auer, D. Tags: Stroke Source Type: research

Atrial Fibrillation, Stroke, and Anticoagulation in Medicare Beneficiaries: Trends by Age, Sex, and Race, 1992-2010 Stroke
Conclusions Ischemic stroke rates among Medicare AF patients decreased significantly in all demographic subpopulations from 1992–2010, coincident with increasing warfarin use. Ischemic stroke rates remained higher and warfarin use rates remained lower for women and blacks with AF, groups whose baseline CHADS scores were higher.
Source: JAHA:Journal of the American Heart Association - June 3, 2014 Category: Cardiology Authors: Shroff, G. R., Solid, C. A., Herzog, C. A. Tags: Stroke Source Type: research

Relationship Between Time in Therapeutic Range and Comparative Treatment Effect of Rivaroxaban and Warfarin: Results From the ROCKET AF Trial Arrhythmia and Electrophysiology
Conclusions The treatment effect of rivaroxaban compared with warfarin for the prevention of stroke and systemic embolism is consistent regardless of cTTR.
Source: JAHA:Journal of the American Heart Association - April 22, 2014 Category: Cardiology Authors: Piccini, J. P., Hellkamp, A. S., Lokhnygina, Y., Patel, M. R., Harrell, F. E., Singer, D. E., Becker, R. C., Breithardt, G., Halperin, J. L., Hankey, G. J., Berkowitz, S. D., Nessel, C. C., Mahaffey, K. W., Fox, K. A. A., Califf, R. M., ROCKET AF Investig Tags: Arrhythmia and Electrophysiology Source Type: research

The TLR9 Ligand, CpG-ODN, Induces Protection against Cerebral Ischemia/Reperfusion Injury via Activation of PI3K/Akt Signaling Stroke
Conclusion CpG-ODN significantly reduces cerebral I/R injury via a PI3K/Akt-dependent mechanism. Our data also indicate that CpG-ODN may be useful in the therapy of cerebral I/R injury.
Source: JAHA:Journal of the American Heart Association - April 10, 2014 Category: Cardiology Authors: Lu, C., Ha, T., Wang, X., Liu, L., Zhang, X., Kimbrough, E. O., Sha, Z., Guan, M., Schweitzer, J., Kalbfleisch, J., Williams, D., Li, C. Tags: Stroke Source Type: research

Intake of Dietary Phylloquinone and Menaquinones and Risk of Stroke Stroke
Conclusion In our study, neither dietary phylloquinone nor dietary menaquinones intake were associated with stroke risk.
Source: JAHA:Journal of the American Heart Association - December 10, 2013 Category: Cardiology Authors: Vissers, L. E. T., Dalmeijer, G. W., Boer, J. M. A., Monique Verschuren, W. M., van der Schouw, Y. T., Beulens, J. W. J. Tags: Stroke Source Type: research

Clinical and Magnetic Resonance Imaging Predictors of Very Early Neurological Response to Intravenous Thrombolysis in Patients With Middle Cerebral Artery Occlusion Stroke
Conclusions Lack of VENI provides an early estimate of 3-month outcome and recanalization after IV-tPA. Baseline NIHSS, onset to treatment time, and diffusion weighted imaging—Alberta Stroke Programme Early CT Score could help to predict lack of VENI and, in turn, might help early selection of candidates for complementary reperfusion strategies.
Source: JAHA:Journal of the American Heart Association - December 5, 2013 Category: Cardiology Authors: Apoil, M., Turc, G., Tisserand, M., Calvet, D., Naggara, O., Domigo, V., Baron, J.-C., Oppenheim, C., Touze, E. Tags: Stroke Source Type: research

Clinical and Magnetic Resonance Imaging Predictors of Very Early Neurological Response to Intravenous Thrombolysis in Patients With Middle Cerebral Artery Occlusion Cardiovascular Surgery
Conclusions Lack of VENI provides an early estimate of 3-month outcome and recanalization after IV-tPA. Baseline NIHSS, onset to treatment time, and diffusion weighted imaging—Alberta Stroke Programme Early CT Score could help to predict lack of VENI and, in turn, might help early selection of candidates for complementary reperfusion strategies.
Source: JAHA:Journal of the American Heart Association - December 5, 2013 Category: Cardiology Authors: Apoil, M., Turc, G., Tisserand, M., Calvet, D., Naggara, O., Domigo, V., Baron, J.-C., Oppenheim, C., Touze, E. Tags: Cardiovascular Surgery Source Type: research

Pulmonary Embolism in Ischemic Stroke: Clinical Presentation, Risk Factors, and Outcome Stroke
Conclusions In this large cohort study, PE occurred in nearly 1% of AIS patients. PE was more common in patients with severe stroke, history of cancer, previous DVT/PE or acute DVT and associated with lower short- and long-term survival, greater disability, and longer length of stay.
Source: JAHA:Journal of the American Heart Association - November 25, 2013 Category: Cardiology Authors: Pongmoragot, J., Rabinstein, A. A., Nilanont, Y., Swartz, R. H., Zhou, L., Saposnik, G., The Investigators of the Registry of the Canadian Stroke Network (RCSN) and University of Toronto Stroke Program for the Stroke Outcomes Research Canada (SORCan [www. Tags: Stroke Source Type: research

Peripheral Endothelial Function and Cardiovascular Events in High-Risk Patients Vascular Medicine
Conclusions Advanced endothelial dysfunction significantly correlated with near future cardiovascular events in high-risk patients. This physiological vascular measurement improved risk discrimination when added to the FRS, BNP, and SYNTAXsc. Clinical Trial Registration URL: clinicaltrials.gov (http://www.clinicaltrials.gov). Unique identifier: NCT00737945.
Source: JAHA:Journal of the American Heart Association - November 25, 2013 Category: Cardiology Authors: Matsuzawa, Y., Sugiyama, S., Sumida, H., Sugamura, K., Nozaki, T., Ohba, K., Matsubara, J., Kurokawa, H., Fujisue, K., Konishi, M., Akiyama, E., Suzuki, H., Nagayoshi, Y., Yamamuro, M., Sakamoto, K., Iwashita, S., Jinnouchi, H., Taguri, M., Morita, S., Ma Tags: Vascular Medicine Source Type: research

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