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Clinical Prediction Model Suitable for Assessing Hospital Quality for Patients Undergoing Carotid Endarterectomy Stroke
Conclusions The NCDR CEA score, comprising 7 clinical variables, predicts in-hospital stroke or death after CEA. This model can be used to estimate hospital risk-adjusted outcomes for CEA and to assist with the assessment of hospital quality.
Source: JAHA:Journal of the American Heart Association - June 17, 2014 Category: Cardiology Authors: Wimmer, N. J., Spertus, J. A., Kennedy, K. F., Anderson, H. V., Curtis, J. P., Weintraub, W. S., Singh, M., Rumsfeld, J. S., Masoudi, F. A., Yeh, R. W. Tags: Stroke Source Type: research

Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation: Data From ROCKET AF Arrhythmia and Electrophysiology
Conclusions In a large population of patients anticoagulated for nonvalvular atrial fibrillation, 7 in 10 deaths were cardiovascular, whereas <1 in 10 deaths were caused by nonhemorrhagic stroke or systemic embolism. Optimal prevention and treatment of heart failure, renal impairment, chronic obstructive pulmonary disease, and diabetes may improve survival. Clinical Trial Registration URL: https://www.clinicaltrials.gov/. Unique identifier: NCT00403767.
Source: JAHA:Journal of the American Heart Association - March 7, 2016 Category: Cardiology Authors: Pokorney, S. D., Piccini, J. P., Stevens, S. R., Patel, M. R., Pieper, K. S., Halperin, J. L., Breithardt, G., Singer, D. E., Hankey, G. J., Hacke, W., Becker, R. C., Berkowitz, S. D., Nessel, C. C., Mahaffey, K. W., Fox, K. A. A., Califf, R. M., for the Tags: Atrial Fibrillation, Sudden Cardiac Death, Heart Failure, Intracranial Hemorrhage, Ischemic Stroke Arrhythmia and Electrophysiology Source Type: research

Efficacy and Safety of Apixaban Compared With Warfarin in Patients With Atrial Fibrillation and Peripheral Artery Disease: Insights From the ARISTOTLE Trial Arrhythmia and Electrophysiology
ConclusionsPatients with PAD in ARISTOTLE had a higher crude risk of stroke or systemic embolism compared with patients without PAD that was not present after adjustment. The benefits of apixaban versus warfarin for stroke and systemic embolism were similar in patients with and without PAD. These findings highlight the need to optimize the treatment of patients with atrial fibrillation and PAD.Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT00412984.
Source: JAHA:Journal of the American Heart Association - January 17, 2017 Category: Cardiology Authors: Hu, P. T., Lopes, R. D., Stevens, S. R., Wallentin, L., Thomas, L., Alexander, J. H., Hanna, M., Lewis, B. S., Verheugt, F. W. A., Granger, C. B., Jones, W. S. Tags: Arrhythmias, Atrial Fibrillation, Anticoagulants, Peripheral Vascular Disease Original Research Source Type: research

Efficacy and Safety of Vorapaxar as Approved for Clinical Use in the United States Coronary Heart Disease
Conclusions In patients with prior MI or PAD who have not had a previous stroke or TIA, vorapaxar added to standard therapy is effective for long-term secondary prevention of thrombotic CV events, while increasing moderate or severe bleeding. Clinical Trial Registration URL: clinicaltrials.gov Unique Identifier: NCT00526474.
Source: JAHA:Journal of the American Heart Association - March 19, 2015 Category: Cardiology Authors: Magnani, G., Bonaca, M. P., Braunwald, E., Dalby, A. J., Fox, K. A. A., Murphy, S. A., Nicolau, J. C., Oude Ophuis, T., Scirica, B. M., Spinar, J., Theroux, P., Morrow, D. A. Tags: Coronary Heart Disease Source Type: research

Hydroxychloroquine Use Is Associated With Decreased Incident Cardiovascular Events in Rheumatoid Arthritis Patients Preventive Cardiology
Conclusion In this hypothesis-generating study, hydroxychloroquine use was associated with a 72% decrease in the risk of incident CVD in RA patients. If these preliminary results are confirmed in larger studies, our findings may be used as a rationale for a randomized study of hydroxychloroquine use for primary prevention of CVD in RA or nonrheumatic high-risk patients.
Source: JAHA:Journal of the American Heart Association - January 4, 2016 Category: Cardiology Authors: Sharma, T. S., Wasko, M. C. M., Tang, X., Vedamurthy, D., Yan, X., Cote, J., Bili, A. Tags: Cardiovascular Disease, Primary Prevention Preventive Cardiology Source Type: research

Sex-Specific Differences in the Predictive Value of Cholesterol Homeostasis Markers and 10-Year Cardiovascular Disease Event Rate in Framingham Offspring Study Participants Coronary Heart Disease
Conclusions These data suggest significant sex differences in the 10-year prognostic value of cholesterol synthesis markers and HCHD, specifically coronary death and incidence of myocardial infarction. Clinical Trial Registration URL:http://ClinicalTrials.gov. Unique identifier: NCT00074464.
Source: JAHA:Journal of the American Heart Association - February 19, 2013 Category: Cardiology Authors: Matthan, N. R., Zhu, L., Pencina, M., D'Agostino, R. B., Schaefer, E. J., Lichtenstein, A. H. Tags: Coronary Heart Disease Source Type: research

Association of 6-Minute Walk Performance and Physical Activity With Incident Ischemic Heart Disease Events and Stroke in Peripheral Artery Disease Vascular Medicine
Conclusions Six-minute walk and physical activity predict IHD event rates in PAD. Further study is needed to determine whether interventions that improve 6-minute walk, physical activity, or both can reduce IHD events in PAD.
Source: JAHA:Journal of the American Heart Association - July 28, 2015 Category: Cardiology Authors: McDermott, M. M., Greenland, P., Tian, L., Kibbe, M. R., Green, D., Zhao, L., Criqui, M. H., Guralnik, J. M., Ferrucci, L., Liu, K., Wilkins, J. T., Huffman, M. D., Shah, S. J., Liao, Y., Lloyd-Jones, D. M. Tags: Vascular Medicine Source Type: research

Long-Term Prognostic Risk in Lower Extremity Peripheral Arterial Disease as a Function of the Number of Peripheral Arterial Lesions Health Services and Outcomes Research
Conclusions Among PAD patients, a greater number of lesions is associated with an increased risk of an adverse prognosis over 3 years of follow-up. Assessing the number of lower extremity lesions might serve as a simple risk-stratification tool at initial PAD diagnosis.
Source: JAHA:Journal of the American Heart Association - October 26, 2015 Category: Cardiology Authors: Smolderen, K. G., van Zitteren, M., Jones, P. G., Spertus, J. A., Heyligers, J. M., Nooren, M. J., Vriens, P. W., Denollet, J. Tags: Health Services and Outcomes Research Source Type: research

Consistency of Hemoglobin A1c Testing and Cardiovascular Outcomes in Medicare Patients With Diabetes Health Services and Outcomes Research
Conclusions Consistent annual hemoglobin A1c testing is associated with fewer adverse cardiovascular outcomes in this observational cohort of Medicare patients of diabetes mellitus.
Source: JAHA:Journal of the American Heart Association - August 9, 2016 Category: Cardiology Authors: Goodney, P. P., Newhall, K. A., Bekelis, K., Gottlieb, D., Comi, R., Chaudrain, S., Faerber, A. E., Mackenzie, T. A., Skinner, J. S. Tags: Diabetes, Type 1, Diabetes, Type 2, Quality and Outcomes, Peripheral Vascular Disease, Vascular Disease Health Services and Outcomes Research Source Type: research

Economic Impact of Moderate-Vigorous Physical Activity Among Those With and Without Established Cardiovascular Disease: 2012 Medical Expenditure Panel Survey Health Services and Outcomes Research
Conclusions Moderate-vigorous PA ≥30 minutes, ≥5 days/week is associated with significantly lower health care spending and resource utilization among individuals with and without established CVD.
Source: JAHA:Journal of the American Heart Association - September 6, 2016 Category: Cardiology Authors: Valero-Elizondo, J., Salami, J. A., Osondu, C. U., Ogunmoroti, O., Arrieta, A., Spatz, E. S., Younus, A., Rana, J. S., Virani, S. S., Blankstein, R., Blaha, M. J., Veledar, E., Nasir, K. Tags: Cardiovascular Disease, Exercise, Lifestyle, Risk Factors Health Services and Outcomes Research Source Type: research

Consistency of Hemoglobin A1c Testing and Cardiovascular Outcomes in Medicare Patients With Diabetes Health Services and Outcomes Research
BackgroundAnnual hemoglobin A1c testing is recommended for patients with diabetes mellitus. However, it is unknown how consistently patients with diabetes mellitus receive hemoglobin A1c testing over time, or whether testing consistency is associated with adverse cardiovascular outcomes.Methods and ResultsWe identified 1 574 415 Medicare patients (2002–2012) with diabetes mellitus over the age of 65. We followed each patient for a minimum of 3 years to determine their consistency in hemoglobin A1C testing, using 3 categories: low (testing in 0 or 1 of 3 years), medium (testing in 2 of 3 years), and high (testing in ...
Source: JAHA:Journal of the American Heart Association - August 9, 2016 Category: Cardiology Authors: Goodney, P. P., Newhall, K. A., Bekelis, K., Gottlieb, D., Comi, R., Chaudrain, S., Faerber, A. E., Mackenzie, T. A., Skinner, J. S. Tags: Diabetes, Type 1, Diabetes, Type 2, Quality and Outcomes, Peripheral Vascular Disease, Vascular Disease Original Research Source Type: research

Association of Cardiovascular Health With Subclinical Disease and Incident Events: The Multi-Ethnic Study of Atherosclerosis Epidemiology
ConclusionsThere is a graded inverse association between CVH scores and measures of subclinical and overt cardiovascular disease that is similar across race/ethnic groups.
Source: JAHA:Journal of the American Heart Association - March 20, 2017 Category: Cardiology Authors: Polonsky, T. S., Ning, H., Daviglus, M. L., Liu, K., Burke, G. L., Cushman, M., Eng, J., Folsom, A. R., Lutsey, P. L., Nettleton, J. A., Post, W. S., Sacco, R. L., Szklo, M., Lloyd-Jones, D. M. Tags: Epidemiology, Lifestyle, Primary Prevention, Race and Ethnicity, Vascular Disease Original Research Source Type: research

Peripheral Artery Disease Prevalence and Incidence Estimated From Both Outpatient and Inpatient Settings Among Medicare Fee-for-Service Beneficiaries in the Atherosclerosis Risk in Communities (ARIC) Study Epidemiology
ConclusionsThis study provides comprehensive estimates of PAD in the inpatient and outpatient settings where the majority of PAD burden was found. PAD is an important circulatory system disorder similar in prevalence to stroke and coronary heart disease.
Source: JAHA:Journal of the American Heart Association - May 3, 2017 Category: Cardiology Authors: Kalbaugh, C. A., Kucharska-Newton, A., Wruck, L., Lund, J. L., Selvin, E., Matsushita, K., Bengtson, L. G. S., Heiss, G., Loehr, L. Tags: Epidemiology, Peripheral Vascular Disease Original Research Source Type: research