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Source: Journal of Neuroimmunology
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Total 89 results found since Jan 2013.
Palmatine, a natural alkaloid, attenuates memory deficits and neuroinflammation in mice submitted to permanent focal cerebral ischemia
Ischemic stroke is one of the major causes of human morbidity and mortality. The pathophysiology of ischemic stroke involves complex events, including oxidative stress and inflammation, that lead to neuronal loss and cognitive deficits. Palmatine (PLT) is a naturally occurring (Coptidis rhizome) isoquinoline alkaloid that belongs to the class of protoberberines and has a wide spectrum of pharmacological and biological effects. In the present study, we evaluated the impact of Palmatine on neuronal damage, memory deficits, and inflammatory response in mice submitted to permanent focal cerebral ischemia induced by middle cere...
Source: Journal of Neuroimmunology - June 17, 2023 Category: Allergy & Immunology Authors: Juliana Fernandes Pereira, Juliana Catharina de Sousa Neves, Analu Arag ão Fonteles, Jéssica Rabelo Bezerra, Rayssa Costa Pires, Ana Thais Araújo da Silva, Francisco Arnaldo Viana Lima, Kelly Rose Tavares Neves, Reinaldo Barreto Oriá, Glauce Socorro d Source Type: research
TREM2, microglial and ischemic stroke
Ischemic stroke (IS) is a leading cause of morbidity and mortality worldwide. Immunity and inflammation are key factors in the pathophysiology of IS. The inflammatory response is involved in all stages of stroke, and microglia are the predominant cells involved in the post-stroke inflammatory response. Resident microglia are the main immune cells of the brain and the first line of defense of the nervous system. After IS, activated microglia can be both advantageous and detrimental to surrounding tissue; they can be divided into the harmful M1 types or the neuro-protective M2 type.
Source: Journal of Neuroimmunology - May 15, 2023 Category: Allergy & Immunology Authors: Hongxia Wang, Xiaoling Li, Qi Wang, Jialiang Ma, Xiaohong Gao, Manxia Wang Tags: Review Article Source Type: research
Ginkgo biloba extract (EGb-761) confers neuroprotection against ischemic stroke by augmenting autophagic/lysosomal signaling pathway
Ginkgo biloba extract (EGb-761) is well-recognized to have neuroprotective properties. Meanwhile, autophagy machinery is extensively involved in the pathophysiological processes of ischemic stroke. The EGb-761 is widely used in the clinical treatment of stroke patients. However, its neuroprotective mechanisms against ischemic stroke are still not fully understood. The present study was conducted to uncover whether the pharmacological effects of EGb-761 can be executed by modulation of the autophagic/lysosomal signaling axis.
Source: Journal of Neuroimmunology - May 4, 2023 Category: Allergy & Immunology Authors: Rui Zang, Fayang Ling, Zhiyuan Wu, Jun Sun, Licong Yang, Zuyin Lv, Nengbo Ji Source Type: research
Calcitriol modulate post-ischemic TLR signaling pathway in ischemic stroke patients
This study aimed to determine the modulat ory effects of calcitriol hormone on post-ischemic immunity response.
Source: Journal of Neuroimmunology - December 26, 2022 Category: Allergy & Immunology Authors: Saeedeh Tajalli-Nezhad, Salimeh Mohammadi, Mohammad Ali Atlasi, Mahdi Kheiran, Sepideh Etehadi Moghadam, Homayoun Naderian, Abolfazl Azami Tameh Source Type: research
Inflammatory profile and white matter hyperintensity burden in acute ischemic stroke patients
Inflammation is involved in small vessel disease (SVD). We aim to clarify whether inflammation related to white matter hyperintensities (WMH), a key component of SVD, may affect the inflammatory response in acute ischemic stroke (AIS) patients. For this, we sequentially measured 10 circulating inflammatory markers and assessed WMH burden on admission MRI in AIS patients treated with thrombectomy. Of 149 patients, 57 (38.3%) had a high WMH burden (Fazekas ≥3). A high WMH burden was associated with 4 markers levels but this association did not remain following multivariable analyses.
Source: Journal of Neuroimmunology - July 28, 2022 Category: Allergy & Immunology Authors: Lucie Rascle, Norbert Nighoghossian, Tae-Hee Cho, Thomas Bochaton, Alexandre Paccalet, Claire Crola Da Silva, Marielle Buisson, Camille Amaz, Julia Fontaine, Elodie Ong, Laurent Derex, Yves Berthezene, Omer Faruk Eker, Nathan Mewton, Michel Ovize, Laura M Tags: Short Communication Source Type: research
Pilot study in human healthy volunteers on the mechanisms underlying remote ischemic conditioning (RIC) – Targeting circulating immune cells and immune-related proteins
Remote ischemic conditioning (RIC) is a novel promising therapy for treatment of neurological diseases, including ischemic stroke. RIC consists of short cycles of ischemia in a distant non-vital organ that may protect other organs against ischemia. Extensive experimental data and some few clinical trials support the neuroprotective role of RIC in ischemic stroke. Nevertheless, the circulating factors involved in this inter-organ communication and neuroprotection are not clarified. This pilot study in humans characterized the innate and adaptive circulating immune cell populations following RIC.
Source: Journal of Neuroimmunology - March 18, 2022 Category: Allergy & Immunology Authors: In ês Mollet, Catarina Martins, Miguel Ângelo-Dias, Ana S. Carvalho, Kerman Aloria, Rune Matthiesen, Miguel Viana Baptista, Luís Miguel Borrego, Helena L.A. Vieira Source Type: research
Increased serum interleukin-34 levels as a novel diagnostic and prognostic biomarker in patients with acute ischemic stroke
Recent data reveal that interleukin-34 (IL-34) can drive inflammatory response, thereby participating in the pathogenesis of inflammatory diseases. However, the potential effect of IL-34 in acute ischemic stroke (AIS) remains unknown. The purpose of this study was to explore whether the levels of serum IL-34 were correlated with clinical severity or prognosis in AIS patients.
Source: Journal of Neuroimmunology - June 29, 2021 Category: Allergy & Immunology Authors: Xiaoyu Huang, Fengzhan Li, Tingting Yang, Hao Li, Tan Liu, Yingying Wang, Minmin Xu, Lisha Yan, Yong Zhang, Yuzhong Wang, Linlin Fu, Deqin Geng Source Type: research
Diagnosing SARS-CoV-2 associated Guillain-Barre syndrome requires cerebro-spinal-fluid studies
We read with interest the article by Papri et al. about a 50yo male who was diagnosed with Guillain Barre syndrome (GBS) subtype acute inflammatory demyelinating polyneuropathy (AIDP) according to the National Institute of Neurological Disorders and Stroke (NINDS) criteria upon the clinical presentation and nerve conduction studies (NCSs) 6 weeks after onset of an infection with SARS-CoV-2 (Papri et al., 2021). The patient received immunoglobulines and recovered slowly but almost completely over a period of 6 months (Papri et al., 2021).
Source: Journal of Neuroimmunology - May 13, 2021 Category: Allergy & Immunology Authors: Josef Finsterer, Fulvio A. Scorza, Carla A. Scorza, Ana C. Fiorini Tags: Letter to the Editor Source Type: research
Elevated plasma levels of galectin-3 binding protein are associated with post-stroke delirium – A pilot study
To explore the role of systemic inflammation in post-stroke delirium, we investigated the level of two inflammatory mediators: high mobility group box 1 (HMGB1) and galectin-3 binding protein (Gal-3BP). Of 571 stroke patients, we compared plasma levels of HMGB1 and Gal-3BP in 79 delirious patients with 81 non-delirious patients matched for age and stroke severity. Delirious patients had higher Gal-3BP level (median: 1440 vs 1053 ng/mL, P
Source: Journal of Neuroimmunology - April 16, 2021 Category: Allergy & Immunology Authors: Elzbieta Klimiec-Moskal, Paulina Pasinska, Katarzyna Kowalska, Aleksandra Klimkowicz-Mrowiec, Joanna Pera, Agnieszka Slowik, Tomasz Dziedzic Tags: Short Communication Source Type: research
Efficacy and safety of intratracheal IFN- γ treatment to reverse stroke-induced susceptibility to pulmonary bacterial infections
Stroke-induced immunosuppression contributes to the development of stroke-associated pneumonia (SAP). Experiments in mice demonstrated that apoptosis of IFN- γ producing cells and reduced IFN-γ secretion resulted in impaired immune responses and the development of pneumonia after middle cerebral artery occlusion (MCAo). In the present study, we investigated the efficacy of intratracheal IFN-γ treatment to prevent SAP and demonstrated that modest benef its on pulmonary cytokine response in IFN-γ treated stroke mice did not prevent spontaneously developing infections and even slightly reduced bacterial clearance of aspirated pneumococci.
Source: Journal of Neuroimmunology - April 3, 2021 Category: Allergy & Immunology Authors: Sandra Jagdmann, Daniel Berchtold, Birgitt Gutbier, Martin Witzenrath, Andreas Meisel, Christian Meisel, Claudia Dames Source Type: research
Lipopolysaccharide binding protein and sCD14 as risk markers of stroke-associated pneumonia
To determine the utility of lipopolysaccharide binding protein (LBP) and soluble CD14 (sCD14) as risk markers of stroke-associated pneumonia (SAP). We included 331 stroke patients. The plasma levels of LBP (median: 19.4 vs 15.3 μg/mL, P
Source: Journal of Neuroimmunology - February 26, 2021 Category: Allergy & Immunology Authors: El żbieta Gradek-Kwinta, Mateusz Czyzycki, Anna Maria Lopatkiewicz, Elzbieta Klimiec-Moskal, Agnieszka Slowik, Tomasz Dziedzic Source Type: research
Gut microbial metabolite TMAO portends prognosis in acute ischemic stroke
Over the recent years, the role of trimethylamine N-oxide (TMAO) as a gut-derived metabolite mediating cardiovascular disease pathogenesis has been under particularly intense scrutiny. The aim was to explore whether TMAO levels were associated with clinical severity or functional outcome in Chinese patients with ischemic stroke.
Source: Journal of Neuroimmunology - February 20, 2021 Category: Allergy & Immunology Authors: Jianli Zhang, Liankun Wang, Jinle Cai, Aidi Lei, Caiwen Liu, Ruidian Lin, Li Jia, Yingzi Fu Source Type: research
Crosstalk between gut microbiome and immunology in the management of ischemic brain injury
Ischemic brain injury is a serious neurological complication, which accrues an immense activation of neuroinflammatory responses. Several lines of research suggested the interconnection of gut microbiota perturbation with the activation of proinflammatory mediators. Intestinal microbial communities also interchange information with the brain through various afferent and efferent channels and microbial by-products. Herein, we discuss the different microelements of gut microbiota and its connection with the host immune system and how change in immune-microbial signatures correlates with the stroke incidence and post-injury n...
Source: Journal of Neuroimmunology - January 30, 2021 Category: Allergy & Immunology Authors: Ziaur Rahman, Manoj P. Dandekar Tags: Review Article Source Type: research
COVID-19 associated with sensorimotor polyradiculoneuropathy and skin lesions: A case report
We reported a patient with COVID-19 (confirmed with Lung HRCT scan and positive SARS-CoV-2 PCR) who developed acute progressive flaccid tetraparesis and maculopapular pigmented plaques on the limbs, 2 weeks after respiratory symptoms.
Source: Journal of Neuroimmunology - November 6, 2020 Category: Allergy & Immunology Authors: Reza Boostani, Fariborz Reazai Talab, Naser Tayyebi Meibodi, Fariba Zemorshidi Source Type: research
The combination of CC chemokine receptor type 5(CCR5) and Treg cells predicts prognosis in patients with ischemic stroke
Regulatory T cells (Tregs) play an important role in T cells. CC chemokine receptor 5 is a highly expressed chemokine receptor in T cells. They play an important role in inflammation and immune response of stroke.
Source: Journal of Neuroimmunology - September 23, 2020 Category: Allergy & Immunology Authors: Jiru Zhang, Gang Liu, Dandan Chen, Zhiqiang Wang, Dan Chen, Youwei Liu, Weifeng Yu Source Type: research
