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Source: Journal of Neuroimmunology
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Total 89 results found since Jan 2013.
Implications of polymorphonuclear neutrophils for ischemic stroke and intracerebral hemorrhage: Predictive value, pathophysiological consequences and utility as therapeutic target
Polymorphonuclear neutrophil granulocytes (PMN) orchestrate the removal of cell debris in ischemic stroke and intracerebral hemorrhage. In both pathologies, high neutrophil to lymphocyte ratios in peripheral blood are predictive of poor outcome in human stroke patients. Following earlier studies indicating that the cerebral microvasculature forms an efficient barrier that impedes neutrophil brain entry, intravital microscopy and immunohistochemistry in the meantime unequivocally revealed the accumulation of PMN in the ischemic and hemorrhagic brain parenchyma.
Source: Journal of Neuroimmunology - April 24, 2018 Category: Allergy & Immunology Authors: Dirk M. Hermann, Christoph Kleinschnitz, Matthias Gunzer Tags: Review Article Source Type: research
Elevated plasma macrophage migration inhibitor factor as a risk factor for the development of post-stroke depression in ischemic stroke
Macrophage migration inhibitory factor (MIF), a central cytokine of the innate immunity and inflammatory responses, has been reported to link to the pathophysiology of cardiovascular disease and depression. The aim of this study was to test the possible association between plasma MIF and the development of post-stroke depression (PSD) in Chinese patients with acute ischemic stroke (AIS).
Source: Journal of Neuroimmunology - April 10, 2018 Category: Allergy & Immunology Authors: Tingting Xu, Shuang Pu, Ying Ni, Mingqing Gao, Xuemei Li, Xianwei Zeng Source Type: research
Immunomodulatory treatment with systemic GM-CSF augments pulmonary immune responses and improves neurological outcome after experimental stroke
Stroke-induced immunodepression is an independent risk factor for stroke-associated pneumonia (SAP). Granulocyte-macrophage colony stimulating factor (GM-CSF) has neuroprotective properties in experimental stroke and been demonstrated to reverse immunodepression in sepsis patients. However, whether GM-CSF restores immune function after stroke preventing SAP and improving outcome is unknown. Here, we demonstrated that GM-CSF treatment improved peripheral and pulmonary leukocyte numbers, peripheral cytokine responses, lowered lung bacterial burden in the early course and improved long-term functional outcome after experimental stroke.
Source: Journal of Neuroimmunology - March 9, 2018 Category: Allergy & Immunology Authors: Claudia Dames, Katarzyna Winek, Yasmin Beckers, Odilo Engel, Andreas Meisel, Christian Meisel Source Type: research
Expressions of chemokines and their receptors in the brain after heat stroke-induced cortical damage
In this study, we observed time course changes of chemokines in rat brain tissues and elucidated what kinds of cortical cells were affected after HS. Male SD rats were anesthetized and randomly separated into two groups as follows: (a) normothermic sham and (b) HS rats. Rats were sacrificed at different time points (0, 1, 3, 6, and 12h after heat exposure, n=5 in each group) to the end of the experiment in order to extract the mRNA/proteins of cortical tissues.
Source: Journal of Neuroimmunology - February 3, 2018 Category: Allergy & Immunology Authors: Yuh-Feng Lin, Tsung-Ta Liu, Chou-Hui Hu, Chun-Chi Chen, Jia-Yi Wang Source Type: research
FasL incapacitation alleviates CD4+ T cells-induced brain injury through remodeling of microglia polarization in mouse ischemic stroke
In this study, we demonstrated that CD4+ T cells could induce M1 microglia polarization through NF- κB signaling pathway, whereas FasL mutant CD4+ T cells significantly reversed this effect. Besides, Th17/Treg cells balance was skewed into Treg cells after FasL mutation.
Source: Journal of Neuroimmunology - February 2, 2018 Category: Allergy & Immunology Authors: Haoran Zhao, Lihua Wan, Yan Chen, He Zhang, Yun Xu, Shuwei Qiu Source Type: research
Tim-4 expression increases in ischemic stroke patients and is associated with poor outcome
T cell immunoglobin and mucin domain (Tim)-4 on monocytes is involved in immune regulation. Here, we investigated Tim-4 expression on circulating monocytes and in plasma of ischemic stroke. Tim-4 expression was significantly increased on day 2 and day 5 after stroke. Furthermore, stroke severity was positively correlated with Tim-4 expression on monocytes or in plasma. Increased Tim-4 expression was related to stroke associated with infection (SAI) on day 2. Up-regulated Tim-4 expression on monocytes or in plasma on day 2 was a risk predictor of outcome.
Source: Journal of Neuroimmunology - November 30, 2017 Category: Allergy & Immunology Authors: Liyun Xu, Zhinan Ye, Binda Wang, Yanyan Huang, Lin Zhou, Chunyan Liu, Dongdong Chen, Maojun Sun, Fangyu Dai, Shuyi Guan, Weiguo Tang Source Type: research
Cofilin signaling in hemin-induced microglial activation and inflammation
Intracerebral hemorrhage (ICH) is the most severe form of stroke and is further exacerbated by the secondary injury involving inflammatory response due to the activation of microglia. This secondary injury is partly due to the toxic effects of hemin, an endogenous breakdown product of hemoglobin. Cofilin, an actin depolymerizing factor, controls actin dynamics and has been previously shown to be involved in mediating neuronal cell death in ischemic conditions and during bacterial lipopolysaccharide induced microglial activation.
Source: Journal of Neuroimmunology - October 19, 2017 Category: Allergy & Immunology Authors: Muhammad Shahdaat Bin Sayeed, Qasim Alhadidi, Zahoor A. Shah Source Type: research
Serum levels of 25-hydroxyvitamin D predicts infarct volume and mortality in ischemic stroke patients
The aim of this study is to determine 25-hydroxyvitamin D [25(OH) D] levels in serum, and investigate their associations with cardiovascular disease (CVD) or all-cause mortality in a 1-year follow-up study in patients with first-ever ischemic stroke.
Source: Journal of Neuroimmunology - October 6, 2017 Category: Allergy & Immunology Authors: Zhong Nie, Xiao-Chun Ji, Jian Wang, Hong-Xing Zhang Source Type: research
Inflammatory responses in Multiple Sclerosis normal-appearing white matter and in non-immune mediated neurological conditions with wallerian axonal degeneration: A comparative study
This study is a systematic comparison of the principal features of the inflammatory-like changes in the WM in different pathological conditions characterized by axonal damage/degeneration, focusing in particular on Multiple Sclerosis (MS) normal-appearing white matter (NAWM) compared to non immune-mediated disorders. The study was performed on sections of NAWM from 15 MS cases, 11 cases of non immune-mediated disorders with wallerian axonal degeneration (stroke, trauma, amyotrophic lateral sclerosis), 3 cases of viral encephalitis, 6 control cases.
Source: Journal of Neuroimmunology - September 8, 2017 Category: Allergy & Immunology Authors: M. Vercellino, C. Trebini, E. Capello, G.L. Mancardi, M.T. Giordana, P. Cavalla Source Type: research
Sepsis biomarkers reprofiling to predict stroke-associated infections
We aimed to evaluate the usefulness of sepsis biomarkers to predict stroke-associated infections. Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), mid-regional pro-adrenomedullin (MR-proADM), presepsin (sCD14), and soluble urokinase-type plasminogen activator receptor (suPAR), were explored in 125 blood samples collected at different time-points. At baseline, MR-proADM was an independent predictor of infection [>0.94pg/mL, OR=3.63 (1.16 –11.33), p=0.026], as well as suPAR at 24h [>2185.8pg/mL, OR=5.81 (1.05 –32.26), p=0.044].
Source: Journal of Neuroimmunology - August 25, 2017 Category: Allergy & Immunology Authors: Alejandro Bustamante, Teresa Garc ía-Berrocoso, Anna Penalba, Dolors Giralt, Alba Simats, Marian Muchada, Elena Zapata, Marta Rubiera, Joan Montaner Source Type: research
Fatty acid binding protein 4 is associated with stroke risk and severity in patients with acute ischemic stroke
The role of fatty acid-binding proteins (FABPs) in atherosclerosis has been investigated. The aim of this study was to verify the hypothesis that higher levels of serum FABP4 could be a biomarker for stroke and associated with stroke severity in Chinese patients with ischemic stroke.
Source: Journal of Neuroimmunology - July 18, 2017 Category: Allergy & Immunology Authors: Li Chang, Jianlong Zhang, Li Liu, Zhen Huang, Yingbo Han, Yanyan Zhu Source Type: research
Late onset neuromyelitis optica mimicking an acute stroke in an elderly patient
We report a case of NMOSD in an elderly patient with extremely late onset (>80years) of disease. The patient presented with findings of sudden onset unilateral symptoms, which is extremely unusual for NMOSD.
Source: Journal of Neuroimmunology - April 17, 2017 Category: Allergy & Immunology Authors: Kushak Suchdev, Sara Razmjou, Praveen Venkatachalam, Omar A. Khan, Wazim Mohamed, Mohammed S. Ibrahim Tags: Short Communication Source Type: research
