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Source: Stroke
Therapy: Stem Cell Therapy

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Total 28 results found since Jan 2013.

Intravenous Bone Marrow Stem Cell Grafts Preferentially Migrate to Spleen and Abrogate Chronic Inflammation in Stroke Basic Sciences
Conclusions— hBMSC transplantation is therapeutic in chronic stroke possibly by abrogating the inflammation-plagued secondary cell death.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Acosta, S. A., Tajiri, N., Hoover, J., Kaneko, Y., Borlongan, C. V. Tags: Animal models of human disease, Pathology of Stroke, Other Stroke Treatment - Surgical Basic Sciences Source Type: research

Intravenous Autologous Bone Marrow Mononuclear Stem Cell Therapy for Ischemic Stroke: A Multicentric, Randomized Trial Clinical Sciences
Conclusions— With the methods used, results of this hitherto first randomized controlled trial indicate that intravenous infusion of BMSCs is safe, but there is no beneficial effect of treatment on stroke outcome. Clinical Trial Registration— URLs: http://ctri.nic.in/Clinicaltrials and http://www.clinicaltrials.gov. Unique identifiers: CTRI-ROVCTRI/2008/091/0004 and NCT0150177.
Source: Stroke - November 24, 2014 Category: Neurology Authors: Prasad, K., Sharma, A., Garg, A., Mohanty, S., Bhatnagar, S., Johri, S., Singh, K. K., Nair, V., Sarkar, R. S., Gorthi, S. P., Hassan, K. M., Prabhakar, S., Marwaha, N., Khandelwal, N., Misra, U. K., Kalita, J., Nityanand, S., for InveST Study Group Tags: Other Stroke Treatment - Medical Clinical Sciences Source Type: research

Neurorestorative Responses to Delayed Human Mesenchymal Stromal Cells Treatment of Stroke in Type 2 Diabetic Rats Basic Sciences
Conclusions—In T2DM stroke rats, delayed hMSC treatment significantly improves neurological functional outcome and increases neurorestorative effects and M2 macrophage polarization. Increasing brain platelet-derived growth factor expression may contribute to hMSC-induced neurorestoration.
Source: Stroke - October 23, 2016 Category: Neurology Authors: Yan, T., Venkat, P., Chopp, M., Zacharek, A., Ning, R., Roberts, C., Zhang, Y., Lu, M., Chen, J. Tags: Cell Therapy, Stem Cells, Diabetes, Type 2, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

Acute or Delayed Systemic Administration of Human Amnion Epithelial Cells Improves Outcomes in Experimental Stroke Basic Sciences
Conclusions—Systemic poststroke administration of hAECs elicits marked neuroprotection and facilitates mechanisms of repair and recovery.
Source: Stroke - February 26, 2018 Category: Neurology Authors: Megan A. Evans, Rebecca Lim, Hyun Ah Kim, Hannah X. Chu, Chantelle V. Gardiner-Mann, Kimberly W.E. Taylor, Christopher T. Chan, Vanessa H. Brait, Seyoung Lee, Quynh Nhu Dinh, Antony Vinh, Thanh G. Phan, Velandai K. Srikanth, Henry Ma, Thiruma V. Arumugam, Tags: Animal Models of Human Disease, Cell Therapy, Stem Cells, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

Human Neural Stem Cell Extracellular Vesicles Improve Recovery in a Porcine Model of Ischemic Stroke Basic Sciences
Conclusions—This study demonstrated for the first time that in a large animal model novel NSC EVs significantly improved neural tissue preservation and functional levels post-MCAO, suggesting NSC EVs may be a paradigm changing stroke therapeutic.
Source: Stroke - April 23, 2018 Category: Neurology Authors: Robin L. Webb, Erin E. Kaiser, Brian J. Jurgielewicz, Samantha Spellicy, Shelley L. Scoville, Tyler A. Thompson, Raymond L. Swetenburg, David C. Hess, Franklin D. West, Steven L. Stice Tags: Animal Models of Human Disease, Basic Science Research, Translational Studies, Treatment, Ischemic Stroke Original Contributions Source Type: research

Delayed Pituitary Adenylate Cyclase-Activating Polypeptide Delivery After Brain Stroke Improves Functional Recovery by Inducing M2 Microglia/Macrophage Polarization Basic Sciences
Conclusions— Our results demonstrated that immunomodulatory strategies capable of redirecting the microglial response toward a neuroprotective M2 phenotype in the late phase of brain ischemia could represent attractive options for stroke treatment in a new and unexploited therapeutical window.
Source: Stroke - January 26, 2015 Category: Neurology Authors: Brifault, C., Gras, M., Liot, D., May, V., Vaudry, D., Wurtz, O. Tags: Embolic stroke Basic Sciences Source Type: research

Systematic Review and Meta-Analysis of Bone Marrow-Derived Mononuclear Cells in Animal Models of Ischemic Stroke Basic Sciences
Conclusions— BMMNCs demonstrate beneficial effects across histological and behavioral outcomes in animal ischemic stroke models. Although study quality has improved over time, considerable degree of heterogeneity calls for standardization in the conduct and reporting of experimentation.
Source: Stroke - May 22, 2016 Category: Neurology Authors: Vahidy, F. S., Rahbar, M. H., Zhu, H., Rowan, P. J., Bambhroliya, A. B., Savitz, S. I. Tags: Cell Therapy, Stem Cells, Ischemic Stroke Basic Sciences Source Type: research

Human Muse Cells Reconstruct Neuronal Circuitry in Subacute Lacunar Stroke Model Basic Sciences
Conclusions—Transplantation at the delayed subacute phase showed muse cells differentiated into neural cells, facilitated neural reconstruction, improved functions, and displayed solid safety outcomes over prolonged graft maturation period, indicating their therapeutic potential for lacunar stroke.
Source: Stroke - January 22, 2017 Category: Neurology Authors: Hiroki Uchida, Kuniyasu Niizuma, Yoshihiro Kushida, Shohei Wakao, Teiji Tominaga, Cesario V. Borlongan, Mari Dezawa Tags: Cell Therapy, Stem Cells, Translational Studies, Ischemic Stroke Original Contributions Source Type: research

Vasculogenesis in Experimental Stroke After Human Cerebral Endothelial Cell Transplantation Basic Sciences
Conclusions— We found attenuation of behavioral and histological deficits coupled with robust vasculogenesis and neurogenesis in endothelial cell–transplanted stroke animals, suggesting that targeting vascular repair sets in motion a regenerative process in experimental stroke possibly via the VEGF pathway.
Source: Stroke - November 25, 2013 Category: Neurology Authors: Ishikawa, H., Tajiri, N., Shinozuka, K., Vasconcellos, J., Kaneko, Y., Lee, H. J., Mimura, O., Dezawa, M., Kim, S. U., Borlongan, C. V. Tags: Animal models of human disease Basic Sciences Source Type: research

Cannabinoid Type-2 Receptor Drives Neurogenesis and Improves Functional Outcome After Stroke Basic Sciences
Conclusions—Our data support that CB2R is fundamental for driving neuroblast migration and suggest that an endocannabinoid tone is required for poststroke neurogenesis by promoting neuroblast migration toward the injured brain tissue, increasing the number of new cortical neurons and, conceivably, enhancing motor functional recovery after stroke.
Source: Stroke - December 22, 2016 Category: Neurology Authors: Isabel Bravo–Ferrer, Maria I. Cuartero, Juan G. Zarruk, Jesus M. Pradillo, Olivia Hurtado, Victor G. Romera, Javier Diaz–Alonso, Juan M. Garcia–Segura, Manuel Guzman, Ignacio Lizasoain, Ismael Galve–Roperh, Maria A. Moro Tags: Stem Cells, Pharmacology, Neurogenesis Original Contributions Source Type: research

Poststroke Sonic Hedgehog Agonist Treatment Improves Functional Recovery by Enhancing Neurogenesis and Angiogenesis Basic Sciences
Conclusions—These data confirm an important role for the hedgehog pathway in poststroke brain repair and functional recovery, suggesting a prolonged treatment window for potential treatment strategy to modulate sonic hedgehog pathway after stroke.
Source: Stroke - May 22, 2017 Category: Neurology Authors: Yongming Jin, Austin Barnett, Yifan Zhang, Xin Yu, Yu Luo Tags: Cerebrovascular Disease/Stroke, Cognitive Impairment, Ischemic Stroke, Neurogenesis Original Contributions Source Type: research

Clinical Outcomes of Transplanted Modified Bone Marrow-Derived Mesenchymal Stem Cells in Stroke: A Phase 1/2a Study Clinical Sciences
Conclusions— In this interim report, SB623 cells were safe and associated with improvement in clinical outcome end points at 12 months. Clinical Trial Registration— URL: https://www.clinicaltrials.gov. Unique identifier: NCT01287936.
Source: Stroke - June 26, 2016 Category: Neurology Authors: Steinberg, G. K., Kondziolka, D., Wechsler, L. R., Lunsford, L. D., Coburn, M. L., Billigen, J. B., Kim, A. S., Johnson, J. N., Bates, D., King, B., Case, C., McGrogan, M., Yankee, E. W., Schwartz, N. E. Tags: Clinical Studies, Ischemia, Stem Cells, Transplantation, Treatment Clinical Sciences Source Type: research

Integrin {alpha}4 Overexpression on Rat Mesenchymal Stem Cells Enhances Transmigration and Reduces Cerebral Embolism After Intracarotid Inȷection Brief Report
Conclusions—ITGA4 overexpression on MSCs enhances transendothelial migration in vitro, but not in vivo, although it improves safety after intracarotid transplantation into stroke rats.
Source: Stroke - September 25, 2017 Category: Neurology Authors: Li–li Cui, Franziska Nitzsche, Evgeny Pryazhnikov, Marina Tibeykina, Laura Tolppanen, Jussi Rytkonen, Tuulia Huhtala, Jing–wei Mu, Leonard Khiroug, Johannes Boltze, Jukka Jolkkonen Tags: Cell Therapy, Translational Studies, Ischemic Stroke Brief Reports Source Type: research

Regenerative Neurogenesis After Ischemic Stroke Promoted by Nicotinamide Phosphoribosyltransferase-Nicotinamide Adenine Dinucleotide Cascade Basic Sciences
Conclusions— Our data demonstrate that the Nampt–NAD cascade may act as a centralizing switch in postischemic regeneration through controlling different sirtuins and therefore represent a promising therapeutic target for long-term recovery of ischemic stroke.
Source: Stroke - June 22, 2015 Category: Neurology Authors: Zhao, Y., Guan, Y.-F., Zhou, X.-M., Li, G.-Q., Li, Z.-Y., Zhou, C.-C., Wang, P., Miao, C.-Y. Tags: Animal models of human disease, Brain Circulation and Metabolism Basic Sciences Source Type: research

Stroke: Highlights of Selected Articles Stroke: Highlights of Selected Articles
Source: Stroke - June 26, 2016 Category: Neurology Tags: Stem Cells, Magnetic Resonance Imaging (MRI), Quality and Outcomes, Ischemic Stroke, Thrombosis Stroke: Highlights of Selected Articles Source Type: research