• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Biliverdin reductase B is a plasma biomarker for intraplaque hemorrhage and a predictor of ischemic stroke in symptomatic carotid stenosis
Background and Aims: Intraplaque hemorrhage (IPH) is a hallmark of atherosclerotic plaque instability. Biliverdin reductase B (BLVRB) is enriched in plasma and plaques from patients with symptomatic carotid atherosclerosis and functionally associated with plaque IPH. We explored the biomarker potential of plasma BLVRB through 1) its correlation with IPH in carotid plaques assessed by magnetic resonance imaging (MRI) and with recurrent ischemic stroke; and 2) its use for monitoring pharmacotherapy targeting IPH in a preclinical setting.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: M. Chemaly, D. Marlevi, M.-J. Iglesias, M. Lengquist, M. Kronqvist, D. Bos, D.H.K. Van Dam-Nolen, A. Van Der Kolk, J. Hendrikse, M. Kassem, L. Matic, J. Odeberg, M.R. De Vries, M.E. Kooi, U. Hedin Source Type: research

Risk of stroke in genetically verified familial hypercholesterolemia: A prospective matched cohort study
Individuals with familial hypercholesterolemia (FH), causing severely elevated LDL-C, are expected to have a higher risk of ischemic stroke. The risk of hemorrhagic stroke and impact of statin use is however not known. We aimed to investigate the risk of incident total, ischemic and hemorrhagic stroke in individuals with FH compared to controls and to explore the association between cumulative statin use and risk of total stroke in FH.
Source: Atherosclerosis - August 27, 2022 Category: Cardiology Authors: Karianne Svendsen, Thomas Olsen, Kathrine J. Vinknes, Liv J. Mundal, Kirsten B. Holven, Martin P. Bogsrud, Trond P. Leren, Jannicke Igland, Kjetil Retterst øl Source Type: research

Leukocytes, platelets and cardiovascular diseases
We read with great interest the recent article in Atherosclerosis by Xu et al. [1]. In a large prospective study comprising 13,929 middle age and elderly individuals of Chinese descent, they showed that the systemic immune-inflammation index (SII), the product of the neutrophil count x platelet count x lymphocyte count, predicted total stroke, ischemic stroke and hemorrhagic stroke over a median follow-up of 8.3 years using multivariate Cox regression analyses [1]. Although there was a threefold increase in coronary heart disease (CAD), SII did not predict CAD or acute coronary syndromes (ACS).
Source: Atherosclerosis - May 7, 2021 Category: Cardiology Authors: Ishwarlal Jialal, Beverley Adams-Huet Tags: Correspondence Source Type: research

Hyperlipidemia as a stroke risk factor: Study of patients from northwest of Iran from 2008 to 2013
Background and Aims: Stroke is one of the leading causes of death and disability worldwide; and hyperlipidemia is one of its major risk factors. Hyperlipidemia is reported to have an etiologic role for small-vessel disease, significantly increasing risk of ischemic stroke, as well as having a limited role in intracranial hemorrhage. Dyslipidemia has been long recognized as a risk factor for coronary artery disease but its role in stroke has become increasingly apparent over the past decade.
Source: Atherosclerosis - December 1, 2020 Category: Cardiology Authors: N. Parnianfard, S.-R. Sadat-Ebrahimi, P. Hoseini Source Type: research

Effect of intravenous thrombolysis in stroke depends on pattern of intracranial internal carotid artery calcification
The pattern of intracranial internal carotid artery calcification (ICAC) has been identified as an effect modifier of endovascular treatment in patients with acute ischemic stroke, but it is unclear whether it modifies the effect of intravenous thrombolysis. The purpose of this study was to evaluate the association between intravenous thrombolysis and 90-day clinical outcome, follow-up infarct volume, intracranial hemorrhage and recanalization across different patterns of ICAC.
Source: Atherosclerosis - November 22, 2020 Category: Cardiology Authors: Frans Kauw, Pim A. de Jong, Richard A.P. Takx, Hugo W.A.M. de Jong, L. Jaap Kappelle, Birgitta K. Velthuis, Jan W. Dankbaar, Dutch acute stroke study (DUST) investigators Source Type: research

Normalized wall index, intraplaque hemorrhage and ulceration of carotid plaques correlate with the severity of ischemic stroke
Carotid atherosclerosis is considered an important cause of ischemic stroke. Tthis study aimed to explore the relationship between plaque features and the severity of stroke, and to identify plaque risk factors for the assessment of the severity of ischemic stroke.
Source: Atherosclerosis - November 5, 2020 Category: Cardiology Authors: Xin Cao, Qingluan Yang, Ye Tang, Lei Pan, Mao Lai, Zekuan Yu, Daoying Geng, Jun Zhang Source Type: research

Normalized wall index, intraplaque hemorrhage and ulceration of carotid plaques are correlated with the severity of ischemic stroke
Carotid atherosclerosis is considered an important cause of ischemic stroke, this study aimed to explore the relationship between plaque features and the severity of stroke, and to identify plaque risk factors for assessing the severity of ischemic stroke.
Source: Atherosclerosis - November 5, 2020 Category: Cardiology Authors: Xin Cao, Qingluan Yang, Ye Tang, Lei Pan, Mao Lai, Zekuan Yu, Daoying Geng, Jun Zhang Source Type: research

Start Of Antiplatelet Therapy Increases The Prevalence Of Intraplaque Hemorrhage In Patients With Advanced Carotid Artery Lesions: A Longitudinal Mr Imaging Study
This study investigates the effect of antiplatelet agents on the formation of IPH.
Source: Atherosclerosis - August 2, 2019 Category: Cardiology Authors: G. Crombag, M. Liem I, E. Koornstra, F. Schreuder HBM, D. van Dam-Nolen HK, C. Lucci, R. van der Geest J, M. Daemen JAP, A. van der Steen F, J. Hendrikse, W. Mess H, A. van der Lugt, J. Wildberger E, R. van Oostenbrugge J, P. Nederkoorn J, M.E. Kooi Tags: E-poster session Source Type: research

Upstream Region Of Carotid Plaque Shows More Intraplaque Hemorrhage In Stroke Patients: The Plaque At Risk (Parisk) Study
Background and Aims: Non-invasive visualization of intraplaque haemorrhage (IPH) as a key marker contributing to plaque vulnerability is rapidly gaining ground. However, the mechanisms contributing to IPH development are incompletely understood. We hypothesise that plaque deformations during every heartbeat lead to tissue damage (, thereby causing IPH. We aim to study non-invasively whether there is a difference in volume of IPH in the upstream region of the plaque in stroke patients with carotid stenosis and IPH.
Source: Atherosclerosis - August 2, 2019 Category: Cardiology Authors: G. Crombag, F. Schreuder HBM, F. Benali, D. van Dam-Nolen HK, C. Lucci, A. van der Steen F, M. Daemen JAP, W. Mess H, A. van der Lugt, P. Nederkoorn J, P. Hofman, R. van Oostenbrugge J, J. Wildberger E, M.E. Kooi Tags: E-poster session Source Type: research

Effect of initiating statin therapy on long-term outcomes of patients with dyslipidemia after intracerebral hemorrhage
Intracerebral hemorrhage (ICH) has a higher mortality than ischemic stroke. Statin is beneficial for stroke, but high potency statin treatment has been associated with the risk of hemorrhagic stroke. The aim of this study was to assess the impact of initiating statin therapy after ICH on cardiovascular outcomes.
Source: Atherosclerosis - July 10, 2019 Category: Cardiology Authors: Ming-Shyan Lin, Yu-Sheng Lin, Shih-Tai Chang, Po-Chang Wang, Victor Chien-Chia Wu, Wey-Yil Lin, Chang-Min Chung Source Type: research

Discontinuing or continuing statin following intracerebral hemorrhage from the view of a national cohort study
Statins improve clinical outcomes in patients with ischemic stroke but there is no evidence of the effect of continuing long-term statin therapy in patients with intracerebral hemorrhage (ICH). The aim of this study was to evaluate the impact of continuing statin after ICH.
Source: Atherosclerosis - August 31, 2018 Category: Cardiology Authors: Chang-Min Chung, Ming-Shyan Lin, Chi-Hung Liu, Tsong-Hai Lee, Shih-Tai Chang, Teng-Yao Yang, Kuo-Li Pan, Yu-Sheng Lin Source Type: research

Strokes, cholesterol and statins: When mortality is an endpoint
The Yi et al. stroke mortality study, with 5.2 million person-years of observation in a representative Korean population cohort with a single baseline total cholesterol (TC) measurement, highlights several important issues [1]. First, the authors note the fact that cholesterol lowering “particularly by statins” does not lower stroke mortality in randomized trials. Second, the fact that 53% of stroke deaths were from hemorrhagic strokes, far surpassing its incidence of about 10–20% in all strokes in many countries [1], and that are mainly nonfatal ischemic strokes.
Source: Atherosclerosis - May 2, 2018 Category: Cardiology Authors: Eddie Vos, Pierre Biron Tags: Correspondence Source Type: research

Total cholesterol and the risk of stroke: A double-edged sword or a blunt knife?
Hypercholesterolemia is a major risk factor for ischemic stroke [1]. Although cholesterol- ‐lowering therapies such as statins have consistently shown reduction in the risk of ischemic stroke, concerns have been raised about the accompanied risk of hemorrhagic stroke, mainly including intracerebral hemorrhage (ICH) [2,3]. Indeed, earlier observational data also suggested low total serum cholesterol (TC) as a risk factor for ICH [4,5]. Hence, would low TC levels have a role in stroke like a double-edged sword, by decreasing the risk of ischemic stroke and increasing the risk of ICH?
Source: Atherosclerosis - January 17, 2018 Category: Cardiology Authors: Luiz S érgio F. de Carvalho Tags: Editorial Source Type: research

Total cholesterol and the risk of stroke: A double-edged sword or a blunt  knife?
Hypercholesterolemia is a major risk factor for ischemic stroke [1]. Although cholesterol-lowering therapies such as statins have consistently shown reduction in the risk of ischemic stroke, concerns have been raised about the accompanied risk of hemorrhagic stroke, mainly including intracerebral hemorrhage (ICH) [2,3]. Indeed, earlier observational data also suggested low total serum cholesterol (TC) as a risk factor for ICH [4,5]. Hence, would low TC levels have a role in stroke like a double-edged sword, by decreasing the risk of ischemic stroke and increasing the risk of ICH?
Source: Atherosclerosis - January 17, 2018 Category: Cardiology Authors: Luiz S érgio F. de Carvalho Tags: Editorial Source Type: research

Impact of physical activity and sedentary behavior on biological risk factors of carotid atherosclerotic plaque instability
Aim: Carotid atherosclerosis plaque instability is increased by intraplaque hemorrhage (IPH) and neovascularization. Oxidative stress is known to promote these two risk factors and induce a vicious circle with IPH and neovascularization. Moreover, it was shown that regular physical activity can reduce oxidative stress by increasing antioxidant defenses whereas sedentary behavior can increase oxidative stress independently to physical activity. The aim of this study was therefore to evaluate the effects of both physical activity and sedentary behavior on the carotid plaque histological characteristics and oxidative stress i...
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Pauline Mury, Antoine Millon, Mathilde Mura, Virginie Nicaise, Vincent Pialoux Source Type: research

Pages: 1  2