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Source: JAMA

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Total 276 results found since Jan 2013.

Vaccination, Acute Myocardial Infarction, and Ischemic Stroke After COVID-19 Infection
To the Editor We would like to highlight some key points about the recent article that reported that patients who received full vaccination against COVID-19 had a reduced risk of acute myocardial infarction (AMI) and ischemic stroke after COVID-19 diagnosis.
Source: JAMA - February 7, 2023 Category: General Medicine Source Type: research

Vaccination, Acute Myocardial Infarction, and Ischemic Stroke After COVID-19 Infection —Reply
In Reply We thank Dr Chu and colleagues for their comments about our Research Letter. Our analysis found that 2 doses of COVID-19 vaccine were associated with a reduced risk of AMI and ischemic stroke after COVID-19, using inverse probability treatment weighting to mitigate the imbalance in patient characteristics by vaccination status.
Source: JAMA - February 7, 2023 Category: General Medicine Source Type: research

Accuracy of Stroke Risk Prediction Models by Race, Sex, and Age
This retrospective cohort study compares stroke-specific algorithms with pooled cohort equations developed for atherosclerotic cardiovascular disease for the prediction of new-onset stroke across different subgroups (race, sex, and age) and the added value of novel machine learning techniques.
Source: JAMA - January 24, 2023 Category: General Medicine Source Type: research

Gout Flare and Cardiovascular Events
In this study, more individuals with gout and cardiovascular events had a history of cardiovascular disease and high to very high cardiovascular risk than matched controls with gout who did not have cardiovascular events.
Source: JAMA - January 3, 2023 Category: General Medicine Source Type: research

Stenting Plus Medical Therapy and Risk of Stroke and Death in Patients With Symptomatic Intracranial Stenosis
To the Editor We have some observations about the CASSISS trial, which did not demonstrate superiority of intracranial stenting added to optimal medical therapy. This finding was similar to the SAMMPRIS and VISSIT trials.
Source: JAMA - December 27, 2022 Category: General Medicine Source Type: research

Stenting Plus Medical Therapy and Risk of Stroke and Death in Patients With Symptomatic Intracranial Stenosis —Reply
In Reply We agree with the comments by Drs Zedde and Pascarella and Drs Alexander and Yu that patient selection in our study may have altered the effect on the outcomes of stenting and medical therapy for patients with intracranial stenosis.
Source: JAMA - December 27, 2022 Category: General Medicine Source Type: research

COVID-19 vs Influenza for Risk of Thrombotic Events in Hospitalized Patients —Reply
In Reply We appreciate the interest in our recent study and the opportunity to share our responses to the comments by Dr Yii and colleagues. We sought to assess whether the risk of arterial and venous thromboembolism among patients hospitalized with COVID-19 differed from those hospitalized with another respiratory viral infection. Patients with influenza in 2018-2019 were selected as the comparator because this pathogen also causes pandemics, results in hospitalization when severe, and is associated with increased risk of acute myocardial infarction, ischemic stroke, and venous thromboembolism. Evaluating outcomes of COVI...
Source: JAMA - December 27, 2022 Category: General Medicine Source Type: research

Remote Ischemic Conditioning vs Usual Care and Neurologic Function in Acute Moderate Ischemic Stroke
To the Editor The Remote Ischemic Conditioning for Acute Moderate Ischemic Stroke (RICAMIS) randomized clinical trial shed new light on remote ischemic conditioning (RIC) as a potential treatment in acute ischemic stroke, although there was a 5.4% absolute risk improvement in excellent outcome with a power of 66%. To reproduce these findings with the same protocol using a power of 80%, a sample size of 2458 patients would be required. Previous trials in acute brain infarction and myocardial infarction have delivered 1 cycle of RIC in the first 6 hours of ischemia with the underlying hypothesis of enhanced penumbra salvage....
Source: JAMA - December 20, 2022 Category: General Medicine Source Type: research

Remote Ischemic Conditioning vs Usual Care and Neurologic Function in Acute Moderate Ischemic Stroke —Reply
In Reply We appreciate the interest shown by Dr Pico and colleagues about our trial that investigated the effect of RIC on neurologic function in patients with acute moderate ischemic stroke. A dose-response relationship between the number of days of RIC (or the number of RICs delivered) and excellent outcomes is important information to determine the best protocol for in-hospital RIC. These data will be investigated in our secondary analysis of the RICAMIS study.
Source: JAMA - December 20, 2022 Category: General Medicine Source Type: research

Vitamin and Mineral Supplements for Primary Prevention of Cardiovascular Disease and Cancer
To the Editor A recent recommendation of the US Preventive Services Task Force (USPSTF) concluded that there is no convincing evidence that vitamin supplements are beneficial for primary prevention of cardiovascular disease or cancer. However, we would like to highlight an important exception: B vitamins used to lower homocysteine levels do prevent stroke.
Source: JAMA - October 18, 2022 Category: General Medicine Source Type: research

Telmisartan and Walking Performance in Peripheral Artery Disease
Lower extremity peripheral artery disease (PAD) is a morbid manifestation of atherosclerosis that affects an estimated 230 million people worldwide. In the context of an aging population and the increasing rates of diabetes, the prevalence of PAD is expected to increase. Patients with PAD, by virtue of having atherosclerosis, have a heightened risk of myocardial infarction and stroke; thus reducing these risks has been the primary focus of most medical interventions. Although these efforts are warranted, recent evidence has broadened awareness that the dominant morbidity involves the limbs, including functional impairment ...
Source: JAMA - October 4, 2022 Category: General Medicine Source Type: research

Ischemic Stroke in Patients With Asymptomatic Severe Carotid Stenosis Without Surgical Intervention
To the Editor In a recent study, the authors reported 133 ipsilateral ischemic strokes among patients with medically treated asymptomatic severe carotid stenosis who did not undergo surgical intervention after a mean follow-up of 4.1 years. During this follow-up period, 55.6% of the 3737 patients died; however, cause of death was not reported in this study. Could some of these deaths have been caused by major strokes, and is it possible that these events were missed?
Source: JAMA - September 27, 2022 Category: General Medicine Source Type: research