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Source: JAMA
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Total 276 results found since Jan 2013.
Clinical Outcomes at 1 Year Following Transcatheter Aortic Valve Replacement
ImportanceIntroducing new medical devices into routine practice raises concerns because patients and outcomes may differ from those in randomized trials.ObjectiveTo update the previous report of 30-day outcomes and present 1-year outcomes following transcatheter aortic valve replacement (TAVR) in the United States.Design, Setting, and ParticipantsData from the Society of Thoracic Surgeons/American College of Cardiology (STS/ACC) Transcatheter Valve Therapies Registry were linked with patient-specific Centers for Medicare & Medicaid Services (CMS) administrative claims data. At 299 US hospitals, 12 182 patients linked wit...
Source: JAMA - March 10, 2015 Category: Journals (General) Source Type: research
Association of NSAID Use With Risk of Bleeding and Cardiovascular Events in Patients Receiving Antithrombotic Therapy After Myocardial Infarction
Conclusions and RelevanceAmong patients receiving antithrombotic therapy after MI, the use of NSAIDs was associated with increased risk of bleeding and excess thrombotic events, even after short-term treatment. More research is needed to confirm these findings; however, physicians should exercise appropriate caution when prescribing NSAIDs for patients who have recently experienced MI.
Source: JAMA - February 24, 2015 Category: Journals (General) Source Type: research
Inconsistent Units of Measure
This article was corrected online.
Source: JAMA - February 24, 2015 Category: Journals (General) Source Type: research
Association Between the Use of Fondaparinux vs Low-Molecular-Weight Heparin and Clinical Outcomes in Patients With Non–ST-Segment Elevation Myocardial Infarction
Conclusions and RelevanceIn routine clinical care of patients with NSTEMI, fondaparinux was associated with lower odds than LMWH of major bleeding events and death both in-hospital and up to 180 days afterward.
Source: JAMA - February 17, 2015 Category: Journals (General) Source Type: research
Effect of Creatine Monohydrate on Clinical Progression in Patients With Parkinson Disease A Randomized Clinical Trial
ImportanceThere are no treatments available to slow or prevent the progression of Parkinson disease, despite its global prevalence and significant health care burden. The National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson Disease program was established to promote discovery of potential therapies.ObjectiveTo determine whether creatine monohydrate was more effective than placebo in slowing long-term clinical decline in participants with Parkinson disease.Design, Setting, and PatientsThe Long-term Study 1, a multicenter, double-blind, parallel-group, placebo-controlled, 1:1 randomized eff...
Source: JAMA - February 10, 2015 Category: Journals (General) Source Type: research
Blood Pressure Lowering in Type 2 Diabetes A Systematic Review and Meta-analysis
ImportanceLowering blood pressure (BP) is widely used to reduce vascular risk in individuals with diabetes.ObjectiveTo determine the associations between BP–lowering treatment and vascular disease in type 2 diabetes.Data Sources and Study SelectionWe searched MEDLINE for large-scale randomized controlled trials of BP–lowering treatment including patients with diabetes, published between January 1966 and October 2014.Data Extraction and SynthesisTwo reviewers independently extracted study characteristics and vascular outcome data. Estimates were stratified by baseline BP and achieved BP, and pooled using fixed-effects m...
Source: JAMA - February 10, 2015 Category: Journals (General) Source Type: research
Association Between Hospitalization for Pneumonia and Subsequent Risk of Cardiovascular Disease
Conclusions and RelevanceHospitalization for pneumonia was associated with increased short-term and long-term risk of CVD, suggesting that pneumonia may be a risk factor for CVD.
Source: JAMA - January 20, 2015 Category: Journals (General) Source Type: research
Cause-Specific Risk of Hospital Admission Related to Extreme Heat in Older Adults
ImportanceHeat exposure is known to have a complex set of physiological effects on multiple organ systems, but current understanding of the health effects is mostly based on studies investigating a small number of prespecified health outcomes such as cardiovascular and respiratory diseases.ObjectivesTo identify possible causes of hospital admissions during extreme heat events and to estimate their risks using historical data.Design, Setting, and PopulationMatched analysis of time series data describing daily hospital admissions of Medicare enrollees (23.7 million fee-for-service beneficiaries [aged ≥65 years] per year; 8...
Source: JAMA - December 24, 2014 Category: Journals (General) Source Type: research
Role of Glycemic Index in the Context of an Overall Heart-Healthy Diet
Randomized trials designed to assess possible effects of a dietary intervention on hard outcomes such as cardiovascular disease (CVD) events, cancer incidence, or all-cause mortality are nearly nonexistent. Clinical end point studies such as these require large sample sizes, long-term follow-up measured in years, and high levels of dietary adherence to attain a valid result. These studies are difficult and expensive to conduct and are consequently rare. An important exception was the PREDIMED Study wherein a Mediterranean diet supplemented with extravirgin olive oil or nuts reduced the incidence of major CVD events (mostly...
Source: JAMA - December 17, 2014 Category: Journals (General) Source Type: research
Low-Dose Aspirin for Primary Prevention of Cardiovascular Events in Japanese Patients 60 Years or Older With Atherosclerotic Risk Factors A Randomized Clinical Trial
Conclusions and RelevanceOnce-daily, low-dose aspirin did not significantly reduce the risk of the composite outcome of cardiovascular death, nonfatal stroke, and nonfatal myocardial infarction among Japanese patients 60 years or older with atherosclerotic risk factors.Trial Registrationclinicaltrials.gov Identifier: NCT00225849.
Source: JAMA - December 17, 2014 Category: Journals (General) Source Type: research
The Diagnosis and Management of Mild Cognitive Impairment A Clinical Review
ImportanceCognitive decline is a common and feared aspect of aging. Mild cognitive impairment (MCI) is defined as the symptomatic predementia stage on the continuum of cognitive decline, characterized by objective impairment in cognition that is not severe enough to require help with usual activities of daily living.ObjectiveTo present evidence on the diagnosis, treatment, and prognosis of MCI and to provide physicians with an evidence-based framework for caring for older patients with MCI and their caregivers.Evidence AcquisitionWe searched PubMed for English-language articles in peer-reviewed journals and the Cochrane Li...
Source: JAMA - December 17, 2014 Category: Journals (General) Source Type: research
Oral Anticoagulants and the Risk of Intracranial Hemorrhage
Conclusions and Relevance Novel oral anticoagulants are uniformly associated with an overall reduced risk of ICH when used for stroke prevention in atrial fibrillation. Any of the currently available NOACs can be considered first line for patients at high risk for ICH.JAMA Neurol. 2013;70(12):1486-1490. doi:10.1001/jamaneurol.2013.4021.
Source: JAMA - December 17, 2014 Category: Journals (General) Source Type: research
Association of the 2011 ACGME Resident Duty Hour Reforms With Mortality and Readmissions Among Hospitalized Medicare Patients
Conclusions and RelevanceAmong Medicare beneficiaries, there were no significant differences in the change in 30-day mortality rates or 30-day all-cause readmission rates for those hospitalized in more intensive relative to less intensive teaching hospitals in the year after implementation of the 2011 ACGME duty hour reforms compared with those hospitalized in the 2 years before implementation.
Source: JAMA - December 10, 2014 Category: Journals (General) Source Type: research
Stroke Risk Following Perioperative Atrial Fibrillation
To the Editor Dr Gialdini and colleagues presented an analysis of stroke risk following perioperative AF. The authors tried to address potential confounders and acknowledged several limitations.
Source: JAMA - December 10, 2014 Category: Journals (General) Source Type: research
