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Source: JAMA
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Total 276 results found since Jan 2013.
Clarification of Guideline Recommendations
This article was corrected online.
Source: JAMA - August 6, 2019 Category: General Medicine Source Type: research
Effect of Intensive vs Standard Treatment of Hyperglycemia on Functional Outcome in Stroke
This randomized clinical trial compares the effects of continuous intravenous vs subcutaneous sliding scale insulin for treatment of hyperglycemia during acute ischemic stroke on functional outcome in adult patients in the United States.
Source: JAMA - July 23, 2019 Category: General Medicine Source Type: research
Endovascular Reperfusion Therapy and Acute Ischemic Stroke Outcomes
This cohort study uses data from the Get With the Guidelines-Stroke registry to report associations between time to treatment and functional outcomes among patients in clinical practice with acute ischemic stroke treated with endovascular recanalization.
Source: JAMA - July 16, 2019 Category: General Medicine Source Type: research
Endovascular Therapy for Acute Ischemic Stroke Treated in Clinical Practice
Five randomized clinical trials, published in 2015, demonstrated the benefit of endovascular therapy in appropriately selected patients with acute ischemic stroke due to large vessel occlusion, and a subsequent individual patient data meta-analysis of these trials indicated that the benefit associated with endovascular therapy was greater the earlier that endovascular reperfusion was achieved. Since publication of these important trials, the use of endovascular therapy in the United States has significantly increased, and efforts are ongoing to maximize the potential benefits of endovascular therapy for the greatest number...
Source: JAMA - July 16, 2019 Category: General Medicine Source Type: research
Omitted Conflict of Interest Disclosures
This article was corrected online.
Source: JAMA - July 9, 2019 Category: General Medicine Source Type: research
Glucose Control in the Perioperative Period —Reply
In Reply In response to Dr Finucane ’s query about our presentation on the risks and benefits of intensive glucose control, we would like to point out that we do not advocate intensive glucose control in the perioperative period. We have, in fact, alluded to studies showing the potential harm of intensive glucose control in the intr aoperative period, and throughout the Clinical Update, we advocated for a target blood glucose of less than 180 mg/dL and avoidance of hypoglycemia. Our comment that “good” (not intensive) glucose control is likely to be beneficial was based on a meta-analysis by Sathya et al, which showe...
Source: JAMA - July 2, 2019 Category: General Medicine Source Type: research
Glucose Control in the Perioperative Period
To the Editor Drs Simha and Shah provided a Clinical Update on perioperative glucose control in patients with diabetes undergoing elective surgery. They stated that “limited evidence suggests that good glucose control is likely to be beneficial in reducing postoperative mortality, length of hospital stay, and cardiovascular complications such as stroke.” In support, they cited a Cochrane Review.
Source: JAMA - July 2, 2019 Category: General Medicine Source Type: research
Early Stroke After TAVR in US Practice
This cohort study uses registry data to describe trends and incidence of 30-day stroke among patients who had undergone transcatheter aortic valve replacement (TAVR) in the first 5 years the procedure ’s use in US clinical practice.
Source: JAMA - June 18, 2019 Category: General Medicine Source Type: research
Stroke After Transcatheter Aortic Valve Replacement
This study reported about a 7% risk of stroke, which was not surprising given the patient population and the likelihood of particulate embolization when expanding a new valve within the annulus of the stenosed and calcified native valve. Nevertheless, even with this stroke risk, there was a clear mortality benefit and quality of life was improved as well. After the PARTNER 1A high-risk cohort demonstrated similar or improved outcomes relative to open surgical aortic valve replacement (SAVR) in patients at high (but not inoperable) surgical risk, the US Food and Drug Administration (FDA) approved TAVR in 2011 and the proced...
Source: JAMA - June 18, 2019 Category: General Medicine Source Type: research
TAVR for Bicuspid vs Tricuspid Aortic Valve Stenosis and Outcomes of Mortality or Stroke
This registry-based cohort study compared mortality and stroke rates among patients with bicuspid and tricuspid aortic stenosis who had undergone TAVR to determine whether advances in technology and in valve devices improved outcomes for patients with bicuspid aortic anatomy.
Source: JAMA - June 11, 2019 Category: General Medicine Source Type: research
Synthesizing Speech From Brain Activity
Writing inNature, researchers at the University of California, San Francisco (UCSF) described a system that synthesizes intelligible speech from brain activity recorded during speaking or mimed speaking. Although theirstudy involved people without speech impairments, the technology could be a stepping stone toward restoring communication for people with stroke, amyotrophic lateral sclerosis, or other neurological disorders that impede speech, the researchers said.
Source: JAMA - June 11, 2019 Category: General Medicine Source Type: research
Prevalence and Payments for Traumatic Injury vs Common Acute Diseases in Medicare Beneficiaries
This study uses Medicare Parts A and B claims data to compare hospitalizations for and spending on traumatic injury vs heart failure, pneumonia, stroke, and acute myocardial infarction in older adults between 2008 and 2014.
Source: JAMA - June 4, 2019 Category: General Medicine Source Type: research
Listen to Your Heart: Alternate Strategies When Symptoms Don ’t Match the Diagnosis
In this narrative medicine essay, an infection diseases physician unconvinced of a stroke diagnosis listened to his own heart beat and accurately diagnosed mitral valve prolapse and reminds physicians to consider other possibilities when the symptoms don ’t line up with the diagnosis.
Source: JAMA - May 14, 2019 Category: General Medicine Source Type: research
Association Between Unrecognized OSA and Cardiovascular Events After Major Noncardiac Surgery
This cohort study assesses the association between unrecognized obstructive sleep apnea (OSA) and 30-day risk of cardiovascular complications (myocardial injury, cardiac death, heart failure, thromboembolism, atrial fibrillation, and stroke) among adults undergoing major noncardiac surgery.
Source: JAMA - May 14, 2019 Category: General Medicine Source Type: research
Rapid Blood Pressure Reduction Safe for Ischemic Stroke
Intensive blood pressure control reduced the risk of intracranial hemorrhage without increasing the risk of death or disability in patients with acute ischemic stroke receiving intravenous thrombolysis, according to atrial published in theLancet. Previous studies raised concern that quickly reducing blood pressure might worsen cerebral ischemia in these patients.
Source: JAMA - April 23, 2019 Category: General Medicine Source Type: research
