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Second death linked to potential antibody treatment for Alzheimer ’s disease
A 65-year-old woman who was receiving a promising experimental treatment to slow the cognitive decline caused by her early Alzheimer’s disease recently died from a massive brain hemorrhage that some researchers link to the drug. The clinical trial death, described in an unpublished case report Science has obtained, is the second thought to be associated with the antibody called lecanemab. The newly disclosed fatality intensifies questions about its safety and how widely lecanemab should be prescribed if ultimately approved by regulators. The woman, who received infusions of the antibody as part of the trial, s...
Source: ScienceNOW - November 28, 2022 Category: Science Source Type: news

Opportunities to better detect, manage and treat patients with undiagnosed atrial fibrillation
(Boston University School of Medicine) Atrial fibrillation (AF) is associated with a higher risk of complications including ischemic stroke, cognitive decline, heart failure, myocardial infarction and death. AF frequently is undetected until complications such as stroke or heart failure occur. A new report led by Boston University School of Medicine (BUSM) researcher Emelia J. Benjamin, MD, ScM, builds upon a recently conducted National Heart, Lung, and Blood Institute's virtual workshop that focused on identifying key research priorities related to AF screening.
Source: EurekAlert! - Medicine and Health - January 25, 2021 Category: International Medicine & Public Health Source Type: news

Heart failure, stroke greater among occupants in motor vehicle accidents
(Boston University School of Medicine) New research has shown that in older adults (65 and older), being an occupant in an automobile during a motor vehicle accident may lead to heart failure or stroke, as compared to pedestrians who are involved in motor vehicle accidents.
Source: EurekAlert! - Medicine and Health - May 23, 2019 Category: International Medicine & Public Health Source Type: news

Developing a New Score: How Machine Learning Improves Risk Prediction
Composite risk scores have been used for decades to identify disease risk and health status in the general population. However, current approaches often fail to identify people who would benefit from intervention or recommend unnecessary intervention. Machine learning promises to improve accuracy, ensuring targeted treatment for patients that need it and reducing unnecessary intervention. Framingham Risk Score, the gold standard for predicting the likelihood of heart disease, predicts hospitalizations with about 56% accuracy. It uses factors such as age, gender, smoking, cholesterol levels, and systolic blood pressure to...
Source: MDDI - November 17, 2017 Category: Medical Devices Authors: Heather R. Johnson Tags: R & D Source Type: news

Sleep Apnea Tied To Gout Risk And Flare-Ups
(Reuters Health) - Sleep apnea may increase the risk of developing gout and experiencing flare-ups, according to a new study. The intense pain and swelling of a joint, often a big toe, that marks gout is caused by the deposition of uric acid crystals in joints and tissues. Sleep apnea, the study team notes, causes periods of oxygen deprivation during the night when people stop breathing, which triggers overproduction of uric acid in the bloodstream. But little was known about the relationship between the two conditions, the study team writes in Arthritis and Rheumatology.  In 2007-2008, almost six percent of men and t...
Source: Healthy Living - The Huffington Post - October 31, 2015 Category: Consumer Health News Source Type: news