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Total 98 results found since Jan 2013.
The Polyherbal Functional Ingredient Containing Ginger, Chinese Date, and Wood Ear Mushroom Protects against Dementia following Metabolic Syndrome
This study was performed to test this hypothesis and to explore the underlying mechanism. Male Wistar rats weighing 180-220 g were induced metabolic syndrome (MetS) with a 16-week high-carbohydrate high-fat diet (HCHF) feeding. The rats with MetS characteristics were orally administered GCJ at various doses (GCJ100, GCJ200, and GCJ300 mg kg-1 BW) 21 days pre-induction and 21 days post-induction of reperfusion injury (I/R) at the right middle cerebral artery (MCAO). Memory was evaluated every 7 days during the study period. At the end of the study, neuron density, AChE activity, and the expressions of eNOS, BDNF, and pERK/E...
Source: Biomed Res - August 11, 2023 Category: Research Authors: Thuntiva Nakyam Jintanaporn Wattanathorn Wipawee Thukham-Mee Supaporn Muchimapura Source Type: research
DL-3-n-butylphthalide improves the endothelium-dependent vasodilation in high-fat diet-fed ApoE < sup > -/- < /sup > mice via suppressing inflammation, endothelial necroptosis and apoptosis
This study aims to explore whether NBP is able to improve endothelium-dependent vasodilation in atherosclerosis and the underlying mechanisms. Male ApoE-/- mice were fed with a high-fat diet (HFD) for 9-16 weeks to establish a model of atherosclerosis. NBP were given to the mice after eating HFD for 6 weeks and atorvastatin served as a positive control. The endothelium-dependent vasodilation, the blood flow velocity, the atherosclerotic lesion area, the serum levels of lipids, inflammatory cytokines and necroptosis-relevant proteins (RIPK1, RIPK3 and MLKL), and the endothelial necroptosis and apoptosis within the aorta wer...
Source: European Journal of Pharmacology - August 3, 2023 Category: Drugs & Pharmacology Authors: Li-Qun Lu Nian-Sheng Li Ming-Rui Li Jiao-Yang Peng Li-Jing Tang Xiu-Ju Luo Jun Peng Source Type: research
Dengyinnaotong attenuates atherosclerotic lesions, gut dysbiosis and intestinal epithelial barrier impairment in the high fat diet-fed ApoE < sup > -/- < /sup > mice
CONCLUSIONS: Our work provides novel preclinical evidence that underpins the multifaceted effects of DYNT in the control of atherosclerosis.PMID:37453620 | DOI:10.1016/j.jep.2023.116916
Source: Atherosclerosis - July 15, 2023 Category: Cardiology Authors: Minqi Xiong Zilong Zhang Jingang Cui Xiaoye Du Yu Chen Teng Zhang Source Type: research
Antioxidant action of xanthine oxidase inhibitor febuxostat protects the liver and blood vasculature in SHRSP5/Dmcr rats
CONCLUSIONS: Overall, the XO inhibitor febuxostat exerted protective effects against NASH and atherosclerosis in SHRSP5/Dmcr rats.PMID:37376883 | DOI:10.32725/jab.2023.009
Source: Atherosclerosis - June 28, 2023 Category: Cardiology Authors: Mai Kakimoto Moe Fujii Ikumi Sato Koki Honma Hinako Nakayama Sora Kirihara Taketo Fukuoka Shang Ran Satoshi Hirohata Kazuya Kitamori Shusei Yamamoto Shogo Watanabe Source Type: research
A cyclic azapeptide ligand of the scavenger receptor CD36/SR-B2 reduces the atherosclerotic lesion progression and enhances plaque stability in apolipoprotein E-deficient mice
Front Pharmacol. 2023 May 30;14:1204905. doi: 10.3389/fphar.2023.1204905. eCollection 2023.ABSTRACTAtherosclerosis is a chronic inflammatory disease of the arterial walls that develops at predisposed sites. As a major risk factor for adverse cardiovascular pathology, atherosclerosis can progress to myocardial infarction and stroke, due to the rupture of unstable atherosclerotic lesions. Macrophage uptake of modified lipoproteins and metabolic dysfunction contributes significantly to the initiation and development of atherosclerotic lesions. The cluster of differentiation 36 receptor [CD36 (SR-B2)] plays a key role in ather...
Source: Atherosclerosis - June 19, 2023 Category: Cardiology Authors: Jade Gauvin Genevi ève Frégeau Hanan Elimam Liliane M énard David Huynh Catherine L ê Ahsanullah Ahsanullah William D Lubell Huy Ong Sylvie Marleau Source Type: research
Melatonin modulates the aggravation of pyroptosis, necroptosis, and neuroinflammation following cerebral ischemia and reperfusion injury in obese rats
This study aimed to investigate the roles of melatonin on pyroptosis, necroptosis, and pro-inflammatory pathways occurring in the I/R brain of obese rats. Male Wistar rats were given a high-fat diet for 16 weeks to induce the obese condition, and then were divided into 4 groups: Sham-operated, I/R treated with vehicle, I/R treated with melatonin (10 mg/kg), and I/R treated with glycyrrhizic acid (10 mg/kg). All drugs were administered via intraperitoneal injection at the onset of reperfusion. The development of neurological deficits, cerebral infarction, histological changes, neuronal death, and glial cell hyperactivation ...
Source: Biochimica et Biophysica Acta - June 11, 2023 Category: Biochemistry Authors: Nuttapong Yawoot Jirakhamon Sengking Piyarat Govitrapong Chainarong Tocharus Jiraporn Tocharus Source Type: research
Can ‘toxic’ bilirubin treat a variety of illnesses?
Generations of medical and biology students have been instilled with a dim view of bilirubin. Spawned when the body trashes old red blood cells, the molecule is harmful refuse and a sign of illness. High blood levels cause jaundice, which turns the eyes and skin yellow and can signal liver trouble. Newborns can’t process the compound, and although high levels normally subside, a persistent surplus can cause brain damage.
Yet later this year up to 40 healthy Australian volunteers may begin receiving infusions of the supposedly good-for-nothing molecule. They will be participating in a phase 1 safety trial, sponsored ...
Source: ScienceNOW - June 8, 2023 Category: Science Source Type: news
SHRSP5/Dmcr rats fed a high-fat and high-cholesterol diet develop disease-induced sarcopenia as nonalcoholic steatohepatitis progresses
CONCLUSIONS: This study suggests that SHRSP5/Dmcr rats could be a useful novel model for investigate the mechanism of secondary sarcopenia disorder associated with nonalcoholic steatohepatitis.PMID:37209870 | DOI:10.1016/j.aanat.2023.152104
Source: Annals of Anatomy - May 20, 2023 Category: Anatomy Authors: Shusei Yamamoto Koki Honma Moe Fujii Mai Kakimoto Sora Kirihara Hinako Nakayama Kazuya Kitamori Ikumi Sato Satoshi Hirohata Shogo Watanabe Source Type: research
