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The association between carotid atherosclerosis and treatment with lithium and antipsychotics in patients with bipolar disorder.
CONCLUSION: Lithium treatment may be associated with less progression in carotid intima-media thickness and the reduced risk for atherosclerosis in adults with bipolar disorder, including those with high cardiovascular disease risk. In addition to age and body mass index, antipsychotics may increase carotid intima-media thickness even in the low cardiovascular disease-risk patients. PMID: 32900219 [PubMed - as supplied by publisher]
Source: The Australian and New Zealand Journal of Psychiatry - September 7, 2020 Category: Psychiatry Authors: Tsai SY, Shen RS, Kuo CJ, Chen PH, Chung KH, Hsiao CY, Huang SH Tags: Aust N Z J Psychiatry Source Type: research

This Under-Utilized Drug Is Actually Critical for Treatment-Resistant Depression
Many people with clinical depression have tried an array of medication and still feel sick. Maybe they’ve tried different selective serotonin reuptake inhibitors (SSRIs) or selective norepinephrine reuptake inhibitors (SNRIs). Maybe they’ve taken these antidepressants along with an antipsychotic (a common strategy to boost effectiveness). Either way, the lack of improvement can make individuals feel even more hopeless and fear the darkness will never lift. If this sounds all-too familiar, you’re definitely not alone. In fact, up to 30 percent of people with depression don’t respond to the first few antidepressants ...
Source: Psych Central - November 27, 2019 Category: Psychiatry Authors: Margarita Tartakovsky, M.S. Tags: Antidepressants Depression Disorders ECT General Medications Treatment Atypical Depression difficult to treat depression Managing Depression MAOIs medication for depression Monoamine Oxidase Inhibitors Severe Depression Treatin Source Type: news

Lithium Carbonate in a Poststroke Population: Exploratory Analyses of Neuroanatomical and Cognitive Outcomes
Conclusions Lithium pharmacotherapy may be associated with gray matter volume change and verbal memory improvement in stroke patients, providing a rationale for future trials assessing therapeutic potential of lithium in a poststroke population.
Source: Journal of Clinical Psychopharmacology - December 19, 2018 Category: Psychiatry Tags: Brief Reports Source Type: research

Mood stabilisers and risk of stroke in bipolar disorder.
CONCLUSIONS: Use of carbamazepine and valproic acid, but not lithium and lamotrigine, is associated with increased risk of stroke in patients with bipolar disorder.Declaration of interestNone. PMID: 30295208 [PubMed - as supplied by publisher]
Source: The British Journal of Psychiatry for Mental Science - October 10, 2018 Category: Psychiatry Tags: Br J Psychiatry Source Type: research

A differential impact of lithium on endothelium-dependent but not on endothelium-independent vessel relaxation
Publication date: 3 June 2016 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 67 Author(s): Bert Bosche, Marek Molcanyi, Thomas Noll, Soham Rej, Birgit Zatschler, Thorsten R. Doeppner, Jürgen Hescheler, Daniel J. Müller, R. Loch Macdonald, Frauke V. Härtel Lithium is drug for bipolar disorders with a narrow therapeutic window. Lithium was recently reported to prevent stroke and protect vascular endothelium but tends to accumulate particularly in the brain and kidney. Here, adverse effects are common; however mechanisms are still vaguely understood. If lithium could also negative...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 17, 2016 Category: Psychiatry Source Type: research

A differential impact of lithium on endothelium–dependent but not on endothelium–independent vessel relaxation
Publication date: Available online 10 February 2016 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry Author(s): Bert Bosche, Marek Molcanyi, Thomas Noll, Soham Rej, Birgit Zatschler, Thorsten R. Doeppner, Jürgen Hescheler, Daniel J. Müller, R. Loch Macdonald, Frauke V. Härtel Lithium is drug for bipolar disorders with a narrow therapeutic window. Lithium was recently reported to prevent stroke and protect vascular endothelium but tends to accumulate particularly in the brain and kidney. Here, adverse effects are common; however mechanisms are still vaguely understood. If lithium could al...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 12, 2016 Category: Psychiatry Source Type: research

A reduced risk of stroke with lithium exposure in bipolar disorder: a population‐based retrospective cohort study
ConclusionsLithium use was significantly related to a reduced risk of stroke in patients with bipolar disorder.
Source: Bipolar Disorders - September 23, 2015 Category: Psychiatry Authors: Chen‐Chia Lan, Chia‐Chien Liu, Ching‐Heng Lin, Tzuo‐Yun Lan, Melvin G McInnis, Chin‐Hong Chan, Tsuo‐Hung Lan Tags: Original Article Source Type: research