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Condition: Hypertension
Drug: Insulin
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Total 368 results found since Jan 2013.
Multi-Omic Approaches to Identify Genetic Factors in Metabolic Syndrome
Compr Physiol. 2021 Dec 29;12(1):3045-3084. doi: 10.1002/cphy.c210010.ABSTRACTMetabolic syndrome (MetS) is a highly heritable disease and a major public health burden worldwide. MetS diagnosis criteria are met by the simultaneous presence of any three of the following: high triglycerides, low HDL/high LDL cholesterol, insulin resistance, hypertension, and central obesity. These diseases act synergistically in people suffering from MetS and dramatically increase risk of morbidity and mortality due to stroke and cardiovascular disease, as well as certain cancers. Each of these component features is itself a complex disease, ...
Source: Comprehensive Physiology - December 29, 2021 Category: Physiology Authors: Karen C Clark Anne E Kwitek Source Type: research
PPAR agonists for the treatment of cardiovascular disease in patients with Diabetes
Conclusions: According to this study, Pioglitazone treatment in type 2 diabetes patients and hypersensitive Ischemic stroke patients is linked to minor ischemic stroke which is recurrent in Asian people. Pioglitazone and the telmisartan treatment have an increasing pleiotropic effect related to the higher PPAR- gamma effects. Further research needs to be conducted with the PPAR mechanism ' s details to confirm the PPAR effect on Ischemic stroke treatment. [Ethiop. J. Health Dev. 2021; 35(3): 249-257]Keywords: PPAR agonist, Dyslipidaemia, Thiazolidinediones, Type 2 diabetes, Pioglitazone, PPAR-alpha, PPAR-gamma, Insulin resistance, Alecardio.
Source: Ethiopian Journal of Health Development - November 25, 2021 Category: African Health Authors: Zheng Xia, Guo Lixia, Zhang Zhijun Source Type: research
Peripheral versus central insulin and leptin resistance: Role in metabolic disorders, cognition, and neuropsychiatric diseases
Neuropharmacology. 2021 Nov 8:108877. doi: 10.1016/j.neuropharm.2021.108877. Online ahead of print.ABSTRACTInsulin and leptin are classically regarded as peptide hormones that play key roles in metabolism. In actuality, they serve several functions in both the periphery and central nervous system (CNS). Likewise, insulin and leptin resistance can occur both peripherally and centrally. Metabolic disorders such as diabetes and obesity share several key features including insulin and leptin resistance. While the peripheral effects of these disorders are well-known (i.e. cardiovascular disease, hypertension, stroke, dyslipidem...
Source: Neuropharmacology - November 11, 2021 Category: Drugs & Pharmacology Authors: Jennifer M Erichsen Jim R Fadel Lawrence P Reagan Source Type: research
The dream of a good night's sleep for our dermatology patients
Are you getting adequate sleep? Chances are that you are not and the repercussions could be profound. Sleep deprivation has been associated with insulin resistance, diabetes mellitus, obesity, hypertension, obstructive sleep apnea, anxiety and depression, and an increased risk of myocardial infarction and stroke. Quality of life (QoL) may suffer by poor job performance, an increased risk of accidents, and family stress.1
Source: Journal of the American Academy of Dermatology - August 2, 2021 Category: Dermatology Authors: Warren R. Heymann Tags: A clinician's perspective Source Type: research
Midkine: a multifaceted driver of atherosclerosis
Clin Chim Acta. 2021 Jul 28:S0009-8981(21)00264-3. doi: 10.1016/j.cca.2021.07.024. Online ahead of print.ABSTRACTAtherosclerosis constitutes the pathological basis of life-threatening events, including heart attack and stroke. Midkine is a heparin-binding growth factor and forms a small protein family with pleiotrophin. Under inflammatory or hypoxic conditions, midkine expression is up-regulated. Upon binding to its receptors, midkine can activate multiple signal pathways to regulate cell survival and migration, epithelial-to-mesenchymal transition, and oncogenesis. Circulating midkine levels are significantly increased in...
Source: International Journal of Clinical Chemistry - July 31, 2021 Category: Chemistry Authors: Zi-Zhen Zhang Gang Wang Shan-Hui Yin Xiao-Hua Yu Source Type: research
High Triglyceride Glucose Index Is Associated with Poor Outcomes in Ischemic Stroke Patients after Reperfusion Therapy
Conclusions: IR, represented by a high TyG index, may predict poor 3-month functional outcomes in patients with AIS who undergo reperfusion therapy.Cerebrovasc Dis
Source: Cerebrovascular Diseases - July 6, 2021 Category: Neurology Source Type: research
Association between Coronary Artery Spasm and the risk of incident Diabetes: A Nationwide population-based Cohort Study
Conclusion: CAS is a risk factor for incident diabetes regardless of sex. However, females aged <50 years have a more apparent risk for CAS-related diabetes than old females, which is not observed in males. The median time of 2.9 years to incident diabetes warrants close follow-up.PMID:34104095 | PMC:PMC8176166 | DOI:10.7150/ijms.57987
Source: International Journal of Medical Sciences - June 9, 2021 Category: Biomedical Science Authors: Ming-Jui Hung Nen-Chung Chang Patrick Hu Tien-Hsing Chen Chun-Tai Mao Chi-Tai Yeh Ming-Yow Hung Source Type: research
