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Total 42 results found since Jan 2013.
Impact of Lifestyle and Socioeconomic Position on the Association Between Non-steroidal Anti-inflammatory Drug Use and Major Adverse Cardiovascular Events: A Case-Crossover Study
ConclusionsThe relative increase in cardiovascular risk associated with NSAID use was not modified by lifestyle or socioeconomic position.
Source: Drug Safety - May 2, 2023 Category: Drugs & Pharmacology Source Type: research
Comparative Risks of Nonsteroidal Antiinflammatory Drugs on Cardiovascular Diseases: A Population-Based Cohort Study
This article is protected by copyright. All rights reserved.PMID:36063443 | DOI:10.1002/jcph.2142
Source: The Journal of Clinical Pharmacology - September 5, 2022 Category: Drugs & Pharmacology Authors: Eric Yuk Fai Wan Esther Yee Tak Yu Linda Chan Anna Hoi Ying Mok Yuan Wang Esther Wai Yin Chan Ian Chi Kei Wong Cindy Lo Kuen Lam Source Type: research
Aspirin and other non-steroidal anti-inflammatory drugs for the prevention of dementia.
CONCLUSIONS: There is no evidence to support the use of low-dose aspirin or other NSAIDs of any class (celecoxib, rofecoxib or naproxen) for the prevention of dementia, but there was evidence of harm. Although there were limitations in the available evidence, it seems unlikely that there is any need for further trials of low-dose aspirin for dementia prevention. If future studies of NSAIDs for dementia prevention are planned, they will need to be cognisant of the safety concerns arising from the existing studies.
PMID: 32352165 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - April 29, 2020 Category: General Medicine Authors: Jordan F, Quinn TJ, McGuinness B, Passmore P, Kelly JP, Tudur Smith C, Murphy K, Devane D Tags: Cochrane Database Syst Rev Source Type: research
Many take anticoagulants and OTC supplements, which poses risk
FINDINGSNearly 98% percent of people prescribed direct-acting oral anticoagulants such as apixaban also used over-the-counter products. Of those, 33% took at least one such product that, in combination with the anticoagulants, could cause dangerous internal bleeding. People taking these medications largely lacked knowledge of some potentially serious interactions.BACKGROUNDDirect-acting oral anticoagulants are the drug of choice for stroke prevention in patients with atrial fibrillation, which occurs most frequently in older patients. Apixaban is one of the most frequently prescribed. However, most people prescribed apix...
Source: UCLA Newsroom: Health Sciences - October 31, 2019 Category: Universities & Medical Training Source Type: news
Arthritis Tied to Heart Disease. Pain Relievers May Be to Blame.
Pain relievers such as ibuprofen and naproxen may account for higher rates of heart disease and stroke in those with osteoarthritis.
Source: NYT Health - August 7, 2019 Category: Consumer Health News Authors: Nicholas Bakalar Tags: Heart Arthritis Osteoarthritis Nonsteroidal Anti-inflammatory Drugs (NSAIDs) Ibuprofen (Drug) Aleve (Drug) Source Type: news
Differences in cardiovascular safety with non ‐steroidal anti‐inflammatory drug therapy ‐ a nationwide study in patients with osteoarthritis
This article is protected by copyright. All rights reserved.
Source: Basic and Clinical Pharmacology and Toxicology - November 28, 2018 Category: Drugs & Pharmacology Authors: Carlo Alberto Barcella,
Morten Lamberts,
Patricia McGettigan,
Emil Loldrup Fosb øl,
Jesper Lindhardsen,
Christian Torp‐Pedersen,
Gunnar Hilmar Gislason,
Anne‐Marie Schjerning Olsen Tags: Original Article Source Type: research
Comparative cardiovascular safety of nonsteroidal anti ‐inflammatory drugs in patients with hypertension: a population‐based cohort study
ConclusionsOur results provide important information about the comparative cardiovascular safety of NSAIDs in patients with hypertension.
Source: British Journal of Clinical Pharmacology - March 13, 2018 Category: Drugs & Pharmacology Authors: Yaa ‐Hui Dong, Chia‐Hsuin Chang, Li‐Chiu Wu, Jing‐Shiang Hwang, Sengwee Toh Tags: DRUG SAFETY Source Type: research
Comparative cardiovascular safety of non ‐steroidal anti‐inflammatory drugs in patients with hypertension: a population‐based cohort study
ConclusionsOur results provide important information about the comparative cardiovascular safety of NSAIDs in patients with hypertension.
Source: British Journal of Clinical Pharmacology - February 22, 2018 Category: Drugs & Pharmacology Authors: Yaa ‐Hui Dong, Chia‐Hsuin Chang, Li‐Chiu Wu, Jing‐Shiang Hwang, Sengwee Toh Tags: DRUG SAFETY Source Type: research
Celecoxib for rheumatoid arthritis.
CONCLUSIONS: Celecoxib may improve clinical symptoms, alleviate pain and contribute to little or no difference in physical function compared with placebo. Celecoxib was associated with fewer numbers of participant withdrawals. Results for incidence of gastroduodenal ulcers (≥ 3 mm) and short-term serious adverse events were uncertain; however, there were few reported events for either.Celecoxib may slightly improve clinical symptoms compared with tNSAIDs. Results for reduced pain and improved physical function were uncertain. Particpants taking celecoxib had lower incidence of gastroduodenal ulcers (≥ 3 mm) and there w...
Source: Cochrane Database of Systematic Reviews - June 9, 2017 Category: General Medicine Authors: Fidahic M, Jelicic Kadic A, Radic M, Puljak L Tags: Cochrane Database Syst Rev Source Type: research
Nonsteroidal anti-inflammatory drugs and cardiovascular safety - translating pharmacological data into clinical readouts.
Authors: Tacconelli S, Bruno A, Grande R, Ballerini P, Patrignani P
Abstract
INTRODUCTION: The pharmacological management of pain includes the use of nonsteroidal anti-inflammatory drugs(NSAIDs). They comprise traditional(t) NSAIDs and selective cyclooxygenase(COX)-2 inhibitors (named coxibs). The analgesic and anti-inflammatory effects of NSAIDs are dependent on the extent and duration of COX-2 inhibition in the spinal cord and inflammatory sites. However, the simultaneous inhibition of COX-2 in the vasculature translates into a prothrombotic phenotype and promotes hypertension and heart failure. Areas covered. Th...
Source: Expert Opinion on Drug Safety - June 2, 2017 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Coxibs Refocus Attention on the Cardiovascular Risks of Non-Aspirin NSAIDs
This article explains how coxibs refocused attention on the cardiovascular safety of NSAIDs and the general implications of that. COX-2 activity/specificity is one factor associated with increased cardiovascular risks; however, these risks cannot be attributed to coxibs alone. The traditional NSAIDs (i.e., meloxicam, etodolac, and nabumetone) have significant COX-2 specificity, but naproxen and ibuprofen have less specificity. All NSAIDs, whether traditional or a coxib, pose some cardiovascular risks. It is possible that clinicians continue to focus more on decreasing the immediate gastric risks than preventing the later c...
Source: American Journal of Cardiovascular Drugs - March 28, 2017 Category: Cardiology Source Type: research
Non ‐steroidal anti‐inflammatory drug‐induced cardiovascular adverse events: a meta‐analysis
Summary
What is known and objectiveAlthough non‐steroidal anti‐inflammatory drugs (NSAIDs) have been studied in randomized, controlled trials and meta‐analyses in an effort to determine their cardiovascular (CV) risks, no consensus has been reached. These studies continue to raise questions, including whether cyclooxygenase‐2 (COX‐2) selectivity plays a role in conferring CV risk. We performed a meta‐analysis of current literature to determine whether COX‐2 selectivity leads to an increased CV risk.
MethodsWe utilized randomized, controlled trials and prospective cohort studies. We selected eight NSAIDs based...
Source: Journal of Clinical Pharmacy and Therapeutics - November 30, 2016 Category: Drugs & Pharmacology Authors: B. R. Gunter, K. A. Butler, R. L. Wallace, S. M. Smith, S. Harirforoosh Tags: Review Article Source Type: research
Celebrex Is No Riskier For Heart Than Other Arthritis Drugs, Study Finds
NEW ORLEANS (AP) — A new study gives some reassurance to arthritis sufferers who want pain relief but are worried about side effects. It finds that Celebrex, a drug similar to ones withdrawn 12 years ago for safety reasons, is no riskier for the heart than some other prescription pain pills that are much tougher on the stomach.
“We do not want patients to suffer with pain and we need to know what is safe to give them,” said Dr. Steven Nissen, the Cleveland Clinic’s heart chief, who led the study. Fear that Celebrex would be worse than alternatives proved unfounded, and “on almost every endpoint it...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 14, 2016 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Arthritis Celebrex Source Type: news
