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Activation of neuronal Ras ‐related C3 botulinum toxin substrate 1 (Rac1) improves post‐stroke recovery and axonal plasticity in mice
We propose that activation of neuronal Rac1 mediates the release of BDNF via PAK1 signaling, which further promotes axonal plasticity and alleviates astrogliosis, and eventually contributes to functional recovery after brain ischemia. Targeting neuronal Rac1 may offer a potential therapeutic target for promoting brain remapping and functional recovery after stroke. AbstractLong-term disability after stroke is common but the mechanisms of post-stroke recovery remain unclear. Cerebral Ras-related C3 botulinum toxin substrate (Rac) 1 contributes to functional recovery after ischemic stroke in mice. As Rac1 plays divergent rol...
Source: Journal of Neurochemistry - May 22, 2021 Category: Neuroscience Authors: Fan Bu, Yashasvee Munshi, J Weldon Furr, Jia ‐wei Min, Li Qi, Anthony Patrizz, Zachary R. Spahr, Akihiko Urayama, Julia K. Kofler, Louise D. McCullough, Jun Li Tags: ORIGINAL ARTICLE Source Type: research

Activation of Neuronal Ras ‐Related C3 Botulinum Toxin Substrate 1 (Rac1) Improves Post‐Stroke Recovery and Axonal Plasticity in Mice
AbstractLong ‐term disability after stroke is common but the mechanisms of post‐stroke recovery is unclear. Cerebral Ras‐related C3 botulinum toxin substrate (Rac) 1 contributes to functional recovery after ischemic stroke in mice. As Rac1 plays divergent roles in individual cell types after central neural system injury, we herein examined the specific role of neuronal Rac1 in post‐stroke recovery and axonal regeneration. Young male mice were subjected to 60‐minutes middle cerebral artery occlusion (MCAO). Inducible deletion of neuronal Rac1 by daily intraperitoneal injection of tamoxifen (2 mg/4 0 g) into Thy1�...
Source: Journal of Neurochemistry - September 21, 2020 Category: Neuroscience Authors: Fan Bu, Yashasvee Munshi, J Weldon Furr, Jia ‐wei Min, Li Qi, Anthony Patrizz, Zachary R. Spahr, Akihiko Urayama, Julia K. Kofler, Louise D. McCullough, Jun Li Tags: ORIGINAL ARTICLE Source Type: research

Tamoxifen promotes white matter recovery and cognitive functions in male mice after chronic hypoperfusion
Publication date: Available online 5 October 2019Source: Neurochemistry InternationalAuthor(s): Yuxue Chen, Yeye Tian, Hao Tian, Qibo Huang, Yongkang Fang, Wei Wang, Yue Wan, Dengji Pan, Minjie XieAbstractCerebral white matter lesions (WMLs) induced by chronic cerebral hypoperfusion are one of the major components of stroke pathology and closely associated with cognitive impairment. However, the repair and related pathophysiology of white matter after brain injury remains relatively elusive and underexplored. Successful neuroregeneration is a method for the potential treatment of CNS disorders. A non-steroidal estrogen rec...
Source: Neurochemistry International - October 6, 2019 Category: Neuroscience Source Type: research

Microvascular Lesions by Estrogen-Induced ID3: Its Implications in Cerebral and Cardiorenal Vascular Disease
We present evidence for how ID3 overexpression in endothelial cells contributes to the development of an estrogen-induced neovascular phenotype with an additional focus on Pyk2 kinase. Our data showed that ID3 overexpression increased neovascularization, cell migration, and spheroid growth of human cerebral microvascular endothelial cells, hCMEC/D3. ID3-overexpressing cells showed significant estrogen-induced G2/M phase transition. Estrogen treatment increased both ID3 phosphorylation; total protein that was inhibited by tamoxifen, and Pyk2-mediated estrogen-induced ID3 mRNA expression. These findings suggest that Pyk2 sig...
Source: Journal of Molecular Neuroscience - February 7, 2015 Category: Neuroscience Source Type: research