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Drug: Tamoxifen

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Screening for clinically relevant drug-drug interactions between direct oral anticoagulants and antineoplastic agents: a pharmacovigilance approach
ConclusionNo signal of DDIs between DOACs and antineoplastic agents was detected, except for DOAC-neratinib. Most DDIs between DOACs and antineoplastic agents may not be clinically relevant. The DDIs between DOACs and neratinib should be further examined in future research.
Source: Journal of Thrombosis and Thrombolysis - August 10, 2023 Category: Hematology Source Type: research

The Incident Ocular Diseases Related to Chemotherapy in Cancer Patients are Associated with Increasing Risk of Incident Stroke
CONCLUSIONS: Incident ocular diseases related to chemotherapy were associated with a significantly higher risk of stroke.PMID:37229341 | PMC:PMC10203719 | DOI:10.6515/ACS.202305_39(3).20221005A
Source: Cancer Control - May 25, 2023 Category: Cancer & Oncology Authors: Kai-Chun Cheng Hung-Pin Tu Tsung-Hsien Lin Kai-Hung Cheng Source Type: research

GSE214776 Endothelial deletion of the cytochrome P450 reductase leads to cardiac remodelling
Contributors : Melina Lopez ; Pedro F Malacarne ; Deepak P Ramanujam ; Timothy Warwick ; Niklas M üller ; Jiong Hu ; Matthias Dewenter ; Andreas Weigert ; Stefan Günther ; Ralf Gilsbach ; Stefan Engelhardt ; Ralf P Brandes ; Flávia RezendeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe cytochrome P450 reductase (POR) transfers electrons to all microsomal cytochrome P450 enzymes (CYP450) thereby driving their activity. In the vascular system, the POR/CYP450 system has been linked to the production of epoxyeicosatrienoic acids (EETs) but also to the generation of reactive oxygen ...
Source: GEO: Gene Expression Omnibus - December 21, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Endothelial deletion of the cytochrome P450 reductase leads to cardiac remodelling
The cytochrome P450 reductase (POR) transfers electrons to all microsomal cytochrome P450 enzymes (CYP450) thereby driving their activity. In the vascular system, the POR/CYP450 system has been linked to the production of epoxyeicosatrienoic acids (EETs) but also to the generation of reactive oxygen species. In cardiac myocytes (CMs), EETs have been shown to modulate the cardiac function and have cardioprotective effects. The functional importance of the endothelial POR/CYP450 system in the heart is unclear and was studied here using endothelial cell-specific, inducible knockout mice of POR (ecPOR−/−). RNA sequencing o...
Source: Frontiers in Physiology - December 2, 2022 Category: Physiology Source Type: research

The role of microglial/macrophagic salt-inducible kinase 3 on normal and excessive phagocytosis after transient focal cerebral ischemia
This study is the first to show a role of SIK3 in Mi/MΦ phagocytosis in CNS diseases, and reveals that promoting Mi/MΦ anti-inflammatory heterogenization inhibits "excessive phagocytosis" of live cells and facilitates "normal phagocytosis" of apoptotic cells. Therefore, inhibition of SIK3 in Mi/MΦ may be a potential therapeutic target in stroke and other CNS diseases with accompanying white matter destruction. In the acute stage of tFCI, Mi/MΦ polarized into different phenotypes. The pro-inflammatory Mi/MΦ phenotype performed an excessive phagocytotic function. In contrast, the anti-inflammatory Mi/MΦ phenotype perfo...
Source: Cellular and Molecular Life Sciences : CMLS - July 21, 2022 Category: Cytology Authors: Ke Wang Chenran Wang Di Chen Yichen Huang Jiaying Li Pengju Wei Ziyu Shi Yue Zhang Yanqin Gao Source Type: research

Bone Marrow-Derived Alk1 Mutant Endothelial Cells and Clonally Expanded Somatic Alk1 Mutant Endothelial Cells Contribute to the Development of Brain Arteriovenous Malformations in Mice
AbstractWe have previously demonstrated that deletion of activin receptor-like kinase 1 (Alk1) or endoglin in a fraction of endothelial cells (ECs) induces brain arteriovenous malformations (bAVMs) in adult mice upon angiogenic stimulation. Here, we addressed three related questions: (1) couldAlk1− mutant bone marrow (BM)-derived ECs (BMDECs) cause bAVMs? (2) is Alk1− ECs clonally expended during bAVM development? and (3) is the number of mutant ECs correlates to bAVM severity? For the first question, we transplanted BM fromPdgfbiCreER;Alk12f/2f mice (EC-specific tamoxifen-inducible Cre withAlk1-floxed alleles) into wi...
Source: Translational Stroke Research - October 21, 2021 Category: Neurology Source Type: research

Aromatase inhibitors use and risk for cardiovascular disease in breast cancer patients: A population-based cohort study
CONCLUSION: Our results indicate an increased risk for ischemic heart disease and arrhythmia in patients treated for more than four years with AIs. This should be considered in the risk-benefit assessment concerning endocrine therapy.PMID:34265496 | DOI:10.1016/j.breast.2021.07.004
Source: Breast - July 15, 2021 Category: Cancer & Oncology Authors: Maria Sund Miguel Garcia-Argibay Hans Garmo Johan Ahlgren Anna-Karin Wennstig Irma Fredriksson Henrik Lindman Antonis Valachis Source Type: research

Activation of neuronal Ras ‐related C3 botulinum toxin substrate 1 (Rac1) improves post‐stroke recovery and axonal plasticity in mice
We propose that activation of neuronal Rac1 mediates the release of BDNF via PAK1 signaling, which further promotes axonal plasticity and alleviates astrogliosis, and eventually contributes to functional recovery after brain ischemia. Targeting neuronal Rac1 may offer a potential therapeutic target for promoting brain remapping and functional recovery after stroke. AbstractLong-term disability after stroke is common but the mechanisms of post-stroke recovery remain unclear. Cerebral Ras-related C3 botulinum toxin substrate (Rac) 1 contributes to functional recovery after ischemic stroke in mice. As Rac1 plays divergent rol...
Source: Journal of Neurochemistry - May 22, 2021 Category: Neuroscience Authors: Fan Bu, Yashasvee Munshi, J Weldon Furr, Jia ‐wei Min, Li Qi, Anthony Patrizz, Zachary R. Spahr, Akihiko Urayama, Julia K. Kofler, Louise D. McCullough, Jun Li Tags: ORIGINAL ARTICLE Source Type: research

Cancers, Vol. 13, Pages 2254: Adjuvant Hormonotherapy and Cardiovascular Risk in Post-Menopausal Women with Breast Cancer: A Large Population-Based Cohort Study
Conclusions: Adjuvant therapy with AI in breast cancer women aged more than 50 years is associated with increased risk of heart failure and combined CV events.
Source: Cancers - May 8, 2021 Category: Cancer & Oncology Authors: Matteo Franchi Roberta Tritto Luigi Tarantini Alessandro Navazio Giovanni Corrao Tags: Article Source Type: research

Activation of Neuronal Ras ‐Related C3 Botulinum Toxin Substrate 1 (Rac1) Improves Post‐Stroke Recovery and Axonal Plasticity in Mice
AbstractLong ‐term disability after stroke is common but the mechanisms of post‐stroke recovery is unclear. Cerebral Ras‐related C3 botulinum toxin substrate (Rac) 1 contributes to functional recovery after ischemic stroke in mice. As Rac1 plays divergent roles in individual cell types after central neural system injury, we herein examined the specific role of neuronal Rac1 in post‐stroke recovery and axonal regeneration. Young male mice were subjected to 60‐minutes middle cerebral artery occlusion (MCAO). Inducible deletion of neuronal Rac1 by daily intraperitoneal injection of tamoxifen (2 mg/4 0 g) into Thy1...
Source: Journal of Neurochemistry - September 21, 2020 Category: Neuroscience Authors: Fan Bu, Yashasvee Munshi, J Weldon Furr, Jia ‐wei Min, Li Qi, Anthony Patrizz, Zachary R. Spahr, Akihiko Urayama, Julia K. Kofler, Louise D. McCullough, Jun Li Tags: ORIGINAL ARTICLE Source Type: research

Deletion of muscarinic acetylcholine receptor 3 in microglia impacts brain ischemic injury.
In conclusion, our data suggest that the upregulation of m3R in microglia and monocytes in stroke has a beneficial effect on the clinical outcome in male mice. PMID: 32927021 [PubMed - as supplied by publisher]
Source: Brain, Behavior, and Immunity - September 10, 2020 Category: Neurology Authors: Costa A, Haage V, Yang S, Wegner S, Ersoy B, Ugursu B, Rex A, Kronenberg G, Gertz K, Endres M, Wolf SA, Kettenmann H Tags: Brain Behav Immun Source Type: research

Microglial-specific depletion of TAK1 is neuroprotective in the acute phase after ischemic stroke
AbstractTransforming growth factor- β-activated kinase 1 (TAK1) is upregulated after cerebral ischemia and contributes to an aggravation of brain injury. TAK1 acts as a key regulator of NF-ΚB and the MAP kinases JNK and p38 and modulates post-ischemic neuroinflammation and apoptosis. Microglia are the main TAK1-expressing immunocomp etent cells of the brain. However, little is known about the function and regulation of microglial TAK1 after cerebral ischemia. Tamoxifen-dependent conditional depletion of TAK1 in microglial cells was induced inCx3cr1creER-Tak1fl/fl mice. ThecreER-negativeTak1fl/fl mice and vehicle-treated ...
Source: Journal of Molecular Medicine - May 6, 2020 Category: Molecular Biology Source Type: research

Cardiotoxicity of Use of Sequential Aromatase Inhibitors in Women With Breast Cancer
AbstractThe association between use of aromatase inhibitors (AIs) and cardiovascular outcomes is controversial. While some observational studies have assessed the cardiovascular safety of AIs as upfront treatments, their cardiotoxicity as sequential treatments with tamoxifen remains unknown. Thus, we conducted a population-based cohort study using data from the United Kingdom Clinical Practice Research Datalink linked to the Hospital Episode Statistics and Office for National Statistics databases. We employed a prevalent new-user design to propensity-score match, in a 1:2 ratio, patients switching from tamoxifen to AIs wit...
Source: American Journal of Epidemiology - April 27, 2020 Category: Epidemiology Source Type: research