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Guidelines for the Intravenous Application of Recombinant Tissue-type Plasminogen Activator (Alteplase), the Second Edition, October 2012: A Guideline From the Japan Stroke Society
In Japan, intravenous alteplase, a recombinant tissue-type plasminogen activator (rt-PA), was approved for an indication of ischemic stroke in 2005 on the basis of the results of a clinical trial with a unique dose of the drug (0.6 mg/kg). The Japan Stroke Society published the guidelines for intravenous application of rt-PA and organized training sessions for proper use all over Japan in an effort to promote the safe, widespread use of intravenous alteplase. Seven years following its approval, clinical experience with intravenous alteplase has accumulated, additional evidence of intravenous alteplase has been found in Jap...
Source: Journal of Stroke and Cerebrovascular Diseases - June 3, 2013 Category: Neurology Authors: Kazuo Minematsu, Kazunori Toyoda, Teruyuki Hirano, Kazumi Kimura, Rei Kondo, Etsuro Mori, Jyoji Nakagawara, Nobuyuki Sakai, Yoshiaki Shiokawa, Norio Tanahashi, Masahiro Yasaka, Yasuo Katayama, Susumu Miyamoto, Akira Ogawa, Makoto Sasaki, Sadao Suga, Taken Tags: Original Articles Source Type: research

Current State of Stroke Care in the Philippines
Stroke remains the leading cause of disability and death in the Philippines. Evaluating the current state of stroke care, the needed resources, and the gaps in health policies and programs is crucial to decrease stroke-related mortality and morbidity effectively. This paper aims to characterize the Philippines' stroke system of care and network using the World Health Organization health system building blocks framework. To integrate existing national laws and policies governing stroke and its risk factors dispersed across many general policies, the Philippine Department of Health (DOH) institutionalized a national policy f...
Source: Frontiers in Neurology - August 17, 2021 Category: Neurology Source Type: research

Effect of alteplase, benzodiazepines and beta-blocker on post-stroke pneumonia: Exploration of VISTA-Acute
by Thanh G. Phan, Richard Beare, Philip M. Bath, Svitlana Ievlieva, Stella Ho, John Ly, Amanda G. Thrift, Velandai K. Srikanth, Henry Ma, on behalf of the VISTA-Acute Collaborators BackgroundPost-stroke pneumonia is a frequent complication of stroke and is associated with high mortality. Investigators have described its associations with beta-blocker. However, there has been no evaluation of the role of recombinant tissue plasminogen activator (RTPA). We postulate that RTPA may modify the effect of stroke on pneumonia by reducing stroke disability. We explore this using data from neuroprotection trials in Virtual Internati...
Source: PLoS One - May 1, 2023 Category: Biomedical Science Authors: Thanh G. Phan Source Type: research

Selection for delayed intravenous alteplase treatment based on a prognostic score
ConclusionSelection of patients between 4·5 and 6 h based on simple clinical measures failed to deliver a population in whom the alteplase effect would be safe and effective.
Source: International Journal of Stroke - January 7, 2013 Category: Neurology Authors: Rachael L Fulton, Kennedy R Lees, Erich Bluhmki, Gabriele Biegert, Gregory W Albers, Stephen M Davis, Geoffrey A Donnan, James C Grotta, Werner Hacke, Markku Kaste, Rüdiger von Kummer, Ashfaq Shuaib, Danilo Toni, , A. Alexandrov, P.W. Bath, L. Claesson, Tags: Research Source Type: research

Brain Imaging Signs and Health-Related Quality of Life after Acute Ischemic Stroke: Analysis of ENCHANTED Alteplase Dose Arm
Conclusions: In thrombolysed AIS patients, right-sided and deep ischemia within the MCA territory predict poor overall HRQoL, whilst features of old cerebral ischemia are associated with reduced physical HRQoL.Cerebrovasc Dis
Source: Cerebrovascular Diseases - July 22, 2020 Category: Neurology Source Type: research

Experience of a neurology service during the 2016 Olympic and Paralympic Games
Conclusions As expected, many athletes with sports-related injuries were evaluated, but cases of diverse acute neurologic pathologies were observed among nonathlete members of the OF and PF. Olympic Games are large, logistically complex events involving thousands of people. Our observations suggest that a comprehensive and detailed plan for neurologic emergencies should be considered for future games.
Source: Neurology Clinical Practice - December 10, 2018 Category: Neurology Authors: da Silva, I. R. F., Gouvea, L., Bruno Nogueira, C., Cravo, V., Liberato, B. B. Tags: Medical care, All Cerebrovascular disease/Stroke, Brain trauma, Critical care Research Source Type: research

Widely available drug may reduce head injury deaths
Early treatment with tranexamic acid could save many lives Related items fromOnMedica Risk/benefit balance of alteplase shifts quickly Earlier thrombolysis improves stroke outcomes Alteplase use linked to reduction in disability after stroke Lengthen GP training to include dementia New guidance to prevent strokes
Source: OnMedica Latest News - October 14, 2019 Category: UK Health Source Type: news