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Super High Dose Beta-blocker Administration for the Patients with Dilated Cardiomyopathy
First case is a 25-year-old female with dilated cardiomyopathy. Left ventricular end-diastolic diameter (LVEDD) was 74  mm and ejection fraction (EF) was 29%. Carvedilol was already uptitrated to 20 mg twice daily. Right heart catheterization (RHC) revealed very low cardiac output (C.O. 2.82 l/min), cardiac index (C.I. 1.47 l/min/m2), stroke volume (SV 29 ml) and rapid heart rate (HR 96/min) despite maximu m dosage of carvedilol in Japan. Carvedilol was uptitrated to 50 mg twice daily and additional 10 mg bisoprolol twice daily was started under administration of low-dose dobutamine.
Source: Journal of Cardiac Failure - September 20, 2017 Category: Cardiology Authors: Akihiro Isotani, Takashi Morinaga, Shintaro Mori, Shinya Ito, Makoto Hyodo, Shinichi Shirai, Kenji Ando Source Type: research

STEMI vs NSTEACS management trends in non-invasive hospital.
CONCLUSION: NSTEACS patients in western province of KSA present at an older age are mostly males and have higher prevalence of hypertension and hyperlipidemia compared with STEMI patients. It is therefore important to identify patients with high-risk profile and put implement measures to reduce these factors. PMID: 27543475 [PubMed - in process]
Source: Indian Heart J - June 30, 2016 Category: Cardiology Authors: Kinsara AJ, Alrahimi JS, Yusuf OB Tags: Indian Heart J Source Type: research

Selective Heart Rate Reduction With Ivabradine Increases Central Blood Pressure in Stable Coronary Artery Disease Clinical Trials
In conclusion, the decrease in HR with ivabradine was associated with an increase in central systolic pressure, which may have antagonized possible benefits of HR lowering in coronary artery disease patients. Clinical Trials—URL: http://www.clinicaltrials.gov. Unique identifier NCT01039389.
Source: Hypertension - May 10, 2016 Category: Cardiology Authors: Rimoldi, S. F., Messerli, F. H., Cerny, D., Gloekler, S., Traupe, T., Laurent, S., Seiler, C. Tags: Hemodynamics, Hypertension, Coronary Artery Disease Clinical Trials Source Type: research

STEMI vs NSTEACS management trends in non-invasive hospital
Conclusion NSTEACS patients in western province of KSA present at an older age are mostly males and have higher prevalence of hypertension and hyperlipidemia compared with STEMI patients. It is therefore important to identify patients with high-risk profile and put implement measures to reduce these factors.
Source: Indian Heart Journal - January 14, 2016 Category: Cardiology Source Type: research