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Blunted cardiovascular effects of beta-blockers in patients with cirrhosis: Relation to severity?
ConclusionWe found the effect of beta-blockade on cardiac index in patients with advanced cirrhosis to be less potent than in patients with early cirrhosis, indicating that underlying cirrhotic cardiomyopathy increases, and the cardiac compensatory reserve becomes more compromised, with disease progression. The differential effects of beta-blockade in the left atrium may be used to predict the effect of beta-blockers on portal pressure, but further studies are needed to investigate this possibility.
Source: PLoS One - June 28, 2022 Category: Biomedical Science Authors: Puria Nabilou Source Type: research

Case Report of High-Grade Atrioventricular Block and Takotsubo Cardiomyopathy
CONCLUSION: When AVB or other arrhythmias initiate a TTC, the patient can experience sudden cardiac death and decompensate quickly. Therefore, clinicians should understand this rare but fatal complication because these patients require pacemakers and beta blockers.PMID:35348088 | PMC:PMC8817916 | DOI:10.7812/TPP/21.006
Source: The Permanente journal - March 29, 2022 Category: General Medicine Authors: Rohan Prasad Mohammad Fahad Salam Shaurya Srivastava Fnu Samreen Zulfiqar Qutrio Baloch Source Type: research

Super High Dose Beta-blocker Administration for the Patients with Dilated Cardiomyopathy
First case is a 25-year-old female with dilated cardiomyopathy. Left ventricular end-diastolic diameter (LVEDD) was 74  mm and ejection fraction (EF) was 29%. Carvedilol was already uptitrated to 20 mg twice daily. Right heart catheterization (RHC) revealed very low cardiac output (C.O. 2.82 l/min), cardiac index (C.I. 1.47 l/min/m2), stroke volume (SV 29 ml) and rapid heart rate (HR 96/min) despite maximu m dosage of carvedilol in Japan. Carvedilol was uptitrated to 50 mg twice daily and additional 10 mg bisoprolol twice daily was started under administration of low-dose dobutamine.
Source: Journal of Cardiac Failure - September 20, 2017 Category: Cardiology Authors: Akihiro Isotani, Takashi Morinaga, Shintaro Mori, Shinya Ito, Makoto Hyodo, Shinichi Shirai, Kenji Ando Source Type: research

STEMI vs NSTEACS management trends in non-invasive hospital.
CONCLUSION: NSTEACS patients in western province of KSA present at an older age are mostly males and have higher prevalence of hypertension and hyperlipidemia compared with STEMI patients. It is therefore important to identify patients with high-risk profile and put implement measures to reduce these factors. PMID: 27543475 [PubMed - in process]
Source: Indian Heart J - June 30, 2016 Category: Cardiology Authors: Kinsara AJ, Alrahimi JS, Yusuf OB Tags: Indian Heart J Source Type: research

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