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Is Fluoxetine Good for Subacute Stroke? A Meta-Analysis Evidenced From Randomized Controlled Trials
Conclusion: In post-stroke treatment, fluoxetine did not improve participants' mRS and NIHSS but improved FMMS and BI. This difference could result from heterogeneities between the trials: different treatment duration, clinical scales sensitivity, patient age, delay of inclusion, and severity of the deficit.
Source: Frontiers in Neurology - March 22, 2021 Category: Neurology Source Type: research

Simple acupuncture combined with fluoxetine in the treatment of poststroke depression: A protocol for systematic review and meta-analysis
Conclusion: This study will provide reliable evidence-based evidence for the clinical application of acupuncture combined with fluoxetine in the treatment of post-stroke depression. OSF Registration number: DOI 10.17605/OSF.IO/5J896.
Source: Medicine - March 12, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Prevention of depression in adults with long-term physical conditions
CONCLUSIONS: Based on evidence of very low certainty, our results may indicate the benefit of pharmacological interventions, during or directly after preventive treatment. Few trials examined short-term outcomes up to six months, nor the follow-up effects at six to 12 months, with studies suffering from great numbers of drop-outs and inconclusive results. Generalisation of results is limited as study populations and treatment regimes were very heterogeneous. Based on the results of this review, we conclude that for adults with long-term physical conditions, there is only very uncertain evidence regarding the implementation...
Source: Cochrane Database of Systematic Reviews - March 5, 2021 Category: General Medicine Authors: Hanna Kampling Harald Baumeister J ürgen Bengel Oskar Mittag Source Type: research

Boon or Bane? Using Antidepressants After Stroke
Depression affects 1 in every 3 adults within the first six months after a stroke [1]. In addition to being common, it increases the burden of illness and hinders recovery from stroke [2], so that adequate measures to treat and prevent depression in this population are needed. The results of the fluoxetine in motor recovery of patients with acute ischaemic stroke (FLAME) trial (n  = 118) showed that stroke survivors treated with fluoxetine had better motor function than their counterparts treated with placebo for 3 months [3].
Source: Maturitas - February 24, 2021 Category: Primary Care Authors: Osvaldo P. Almeida, Joshua Jones, Graeme J. Hankey, Maree Hackett Source Type: research

Meta-analysis of the clinical effectiveness of combined acupuncture and Western Medicine to treat post-stroke depression
CONCLUSION: The therapeutic effects of acupuncture combined with Western Medicine on post-stroke depression are often better than those of Western Medicine alone, and fewer adverse reactions occur. However, more high-quality RCTs are needed to further confirm these findings.PMID:33522192 | DOI:10.19852/j.cnki.jtcm.2021.01.002
Source: Journal of Traditional Chinese Medicine - February 1, 2021 Category: Complementary Medicine Authors: Xue Wang Jun Xiong Jun Yang Ting Yuan Yunfeng Jiang Xiaohong Zhou Kai Liao Lingling Xu Source Type: research

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