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A global comprehensive analysis of ambient low temperature and non-communicable diseases burden during 1990-2019
In conclusion, ambient low temperature contributes to substantial NCD burden with notable geographical variations.PMID:35501439 | DOI:10.1007/s11356-022-20442-4
Source: Environmental Science and Pollution Research International - May 2, 2022 Category: Environmental Health Authors: Jian Song Wei Qin Rubing Pan Weizhuo Yi Shasha Song Jian Cheng Hong Su Source Type: research

Lipid levels, apolipoproteins, and risk of incident atrial fibrillation in men: A report from the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD)
Atrial fibrillation (AF) is the most common of all sustained cardiac arrhythmias, with an estimated 6 –12 million people worldwide suffering from this condition in the US by 2050 and 17.9 million people in Europe by 20601. AF patients are at higher risk of cardiovascular disease, including congestive heart failure and stroke, and total and cardiac mortality2-4. Dyslipidemia [abnormal level of trig lycerides (TG) and/or total cholesterol (TC)] and dyslipoproteinemia [abnormal level of lipoproteins, e.g.
Source: Journal of Clinical Lipidology - April 23, 2022 Category: Lipidology Authors: Behnam Tajik, Tomi-Pekka Tuomainen, Rand Jarroch, Jussi Kauhanen, Gregory Y.H. Lip, Masoud Isanejad Tags: Journal of Clinical Lipidology Source Type: research

Myocardial Work in Aortic Regurgitation: It  Also Works!
The management of chronic severe aortic regurgitation (AR), specifically the timing of intervention, remains challenging. The interplay between increasing left ventricular (LV) dilation and eccentric LV hypertrophy maintains stroke volume, resulting in both an increased preload and an increased afterload state. These mechanisms account for the “long latent phase” of chronic severe AR. Only once these mechanisms of LV compensation are exhausted does LV ejection fraction (LVEF) begin to decline. The 2020 American College of Cardiology/American Heart Association valve guidelines are similar to European guidelines and reco...
Source: Journal of the American Society of Echocardiography - April 5, 2022 Category: Cardiology Authors: Renuka Jain, Patrycja Galazka, Bijoy K. Khandheria, A. Jamil Tajik Tags: Editorial Comment Source Type: research

Benefits and Limitations of Long-Term Eculizumab Treatment for Paroxysmal Nocturnal Hemoglobinuria (PNH): Real-World Data from Large Cohort Study in Russia
Conclusions: The results of the study show both the high efficacy and limitations of treatment with eculizumab for PNH in real-world practice. Prospectively confirmed significant improvement of the overall survival on eculizumab stress the need for faster and wider access to costly therapy. Nevertherless, a number of limitations, including BTH and extravascular hemolysis, lack of control of bone marrow failure and further clonal evolution, determine the relevance of next-generation complement inhibitors and risk-adjusted allogeneic HSCT as a curative option.DisclosuresKulagin: Alexion Pharmaceuticals, Inc: Consultancy, Honoraria.
Source: Blood - November 21, 2018 Category: Hematology Authors: Kulagin, A., Klimova, O., Rudakova, T., Golubovskaya, I., Ivanova, M., Smirnova, A., Lapina, A., Bykova, T., Babenko, E., Popova, M., Dobronravov, V., Afanasyev, B. Tags: 508. Bone Marrow Failure: Poster II Source Type: research

Frequent Periodic Leg Movement during Sleep Is Associated with Left Ventricular Hypertrophy and Adverse Cardiovascular Outcomes
Conclusions: Frequent periodic leg movement during sleep is an independent predictor of severe LVH and is associated with increased cardiovascular morbidity and mortality.
Source: Journal of the American Society of Echocardiography - April 26, 2013 Category: Cardiology Authors: Mahek Mirza, Win-Kuang Shen, Aamir Sofi, Ahad Jahangir, Naoyo Mori, A. Jamil Tajik, Arshad Jahangir Tags: Sleep Disordered Breathing Source Type: research