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Where You Live Can Shape How Alzheimer ’ s Affects You
The FDA in mid-July for the first time ever approved an Alzheimer’s drug, Leqembi. The annual price-tag will run patients $26,500. The same week, the Alzheimer’s Association for the first time ever released county-level data to identify which communities are most struggling with the disease. 6.7 million Americans live with Alzheimer’s disease and 134,000 of them will die because of it each year. We’ve known these aggregate numbers for a while now, but with new data and new drugs, healthcare specialists can now better target attention and resources. [time-brightcove not-tgx=”true”] ...
Source: TIME: Health - August 7, 2023 Category: Consumer Health News Authors: Jeremy Ney Tags: Uncategorized freelance Source Type: news

Extreme Heat Is Endangering America ’ s Workers —And Its Economy
This project was supported by the Pulitzer Center 7 A.M.: COPELAND FARMS—ROCHELLE, GA Just after dawn on a recent July day in Rochelle, Ga., Silvia Moreno Ayala steps into a pair of sturdy work pants, slips on a long-sleeved shirt, and slathers her face and hands with sunscreen. She drapes a flowered scarf over her wide-brimmed hat to protect her neck and back from the punishing rays of the sun. There isn’t much she can do about the humidity, however. Morning is supposed to be the coolest part of the day, but sweat is already pooling in her rubber boots. [time-brightcove not-tgx=”true”] ...
Source: TIME: Health - August 3, 2023 Category: Consumer Health News Authors: Aryn Baker / Georgia Tags: Uncategorized climate change Climate Is Everything feature healthscienceclimate Source Type: news

Medical and Pharmacy Students Celebrate Match Day
The annual event – held online due the COVID-19 pandemic – marks a rite of passage for students as they start their careers after graduation. Thursday University of Arizona Health Sciencesmatch-day-2400x1350-2021-v2-01-hero-web.png On March 19, Health Sciences students at the Colleges of Medicine – Tucson and Phoenix participated in Match Day and learned the location of the residency training program where they will start their careers as physicians.HealthCollege of Medicine - PhoenixCollege of Medicine - TucsonCollege of Pharmacy Media contact(s)Stacy Pigott University of Arizona Health Sciencesspigott@arizon...
Source: The University of Arizona: Health - March 25, 2021 Category: Universities & Medical Training Authors: mittank Source Type: research

Impaired Activity of Ryanodine Receptors Contributes to Calcium Mishandling in Cardiomyocytes of Metabolic Syndrome Rats
Conclusion Principal findings of this work are that abnormal Ca2+ transient amplitude, contractile dysfunction; and impaired relaxation of MetS cardiomyocytes underlies intrinsic dysfunctional RyR2 and SERCA pump. Abnormal activity of RyRs was evidenced by its decreased ability to bind [3H]-ryanodine. Although the MetS condition does not modify RyR2 protein expression, its phosphorylation at Ser2814 is decreased, which impairs its capacity for activation during ECC. The dysfunctional RyRs, together with a decreased activity of SERCA pump due to decreased Thr17-PLN phosphorylation suggest a downregulation of CaMKII in MetS...
Source: Frontiers in Physiology - April 29, 2019 Category: Physiology Source Type: research

Influence of Sex on Stroke Prognosis: A Demographic, Clinical, and Molecular Analysis
Conclusion Our data suggest that women who suffer from IS present with a poorer functional outcome than men at 3-months, regardless of other preclinical and clinical factors during the acute phase. These relationships seem to be mediated by atrial dysfunction and inflammation. The inflammatory response is slightly higher in women; however, there are no sex differences in their functional behavior. There is a probable relationship between the molecular marker of atrial dysfunction NT-proBNP and worse functional outcome in women, and the connection seems to be more important in cardioembolic stroke patients. In patients wi...
Source: Frontiers in Neurology - April 16, 2019 Category: Neurology Source Type: research

Collectivism Is Associated With Greater Neurocognitive Fluency in Older Adults
This study aimed to evaluate the impact of self-construal on neurocognitive functions in older adults. A total of 86 community-dwelling older adults 60 years and older were assessed with three common self-report measures of self-construal along individualism and collectivism (IC). A cognitive battery was administered to assess verbal and non-verbal fluency abilities. Latent profile analysis (LPA) was used to categorize individuals according to IC, and one-way analyses of covariance (ANCOVA), including relevant covariates (e.g., ethnicity, gender, linguistic abilities), were used to compare neurocognitive functions between ...
Source: Frontiers in Human Neuroscience - April 10, 2019 Category: Neuroscience Source Type: research

DataFlash: Data Indexers
The Institute for Health Metrics and Evaluation (IHME) is “an independent population health research center at UW Medicine, part of the University of Washington, that provides rigorous and comparable measurement of the world’s most important health problems and evaluates the strategies used to address them.” Their mission is to improve the health of the world’s populations by providing the best information on population health, and to do so, IHME enlists the expertise of countless individuals, including researchers, data analysts, data scientists, and thirteen data indexers. What is a data indexer? ...
Source: Dragonfly - April 2, 2018 Category: Databases & Libraries Authors: Ann Madhavan Tags: Data Science Source Type: news