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Association of a genetic variant in the AKT gene locus and cardiovascular risk factors.
Authors: Kermanshahi F, Ghazizadeh H, Hussein NA, Amerizadeh F, Samadi S, Tayefi M, Kamel Khodabandeh A, Moohebati M, Ebrahimi M, Esmaily H, Sahebi R, Abdulkarimi R, Mousavi SAR, Ferns GA, Avan A, Ghayour-Mobarhan M Abstract Cardiovascular disease (CVDs) is the leading cause of morbidity and death worldwide. Most genetic variants could be identified by several genome-wide-association-studies (GWAS), including within genes encoding proteins involved in the AKT/PI3K pathways that are related with an increased risk of metabolic syndrome and CVDs. Therefore, due to the importance of genetic variants in the prognosis of...
Source: Cellular and Molecular Biology - June 18, 2020 Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer ’s Disease Through Activation of BDNF-TrkB Signaling Pathway
Conclusion The data in this manuscript demonstrates that apelin-13 upregulates BDNF against STZ-induced congnitive impairment by suppressing glial cell activity and inflammatory factors release. This suggests apelin signaling may be a new target in the treatment of AD. Ethics Statement All experimental protocols were carried out according to the National Institutes of Health Guide for the Care and Use of Laboratory Animals approved by the Central South University at XiangYa Animal Care and Use Committee. Author Contributions XqQ and LH conceived the study and contributed to its experimental design. HqL carried out the...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research

Association of body mass index with serum calcium and phosphate levels
ConclusionWe found an association between serum calcium and BMI as well as with serum phosphate and menopausal status.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 11, 2019 Category: Endocrinology Source Type: research

Nutrients intake, and serum calcium and phosphorus levels: An evidence ‐based study
ConclusionWe found that the dietary intake of Ca was not sufficient in our population and was associated with the dietary intake of some macro‐ and micronutrient, supporting further investigation on clinical impact of this condition on calcium/phosphorus deficiency related diseases.
Source: Journal of Clinical Laboratory Analysis - November 7, 2017 Category: Laboratory Medicine Authors: Zahra Jafari Giv, Amir Avan, Farshid Hamidi, Maryam Tayefi, Sayyed Saeid Khayyatzadeh, Ali Javandoost, Mohsen Nematy, Gordon A. Ferns, Majid Ghayour Mobarhan Tags: RESEARCH ARTICLE Source Type: research

Nutrients intake, and serum calcium and phosphorus levels: An  evidence‐based study
ConclusionWe found that the dietary intake of Ca was not sufficient in our population and was associated with the dietary intake of some macro‐ and micronutrient, supporting further investigation on clinical impact of this condition on calcium/phosphorus deficiency related diseases.
Source: Journal of Clinical Laboratory Analysis - September 1, 2017 Category: Laboratory Medicine Authors: Zahra Jafari Giv, Amir Avan, Farshid Hamidi, Maryam Tayefi, Sayyed Saeid Khayyatzadeh, Ali Javandoost, Mohsen Nematy, Gordon A. Ferns, Majid Ghayour Mobarhan Tags: RESEARCH ARTICLE Source Type: research