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Total 491 results found since Jan 2013.

Modeling the public health impact of voxelotor in the management of sickle cell disease in France
The objective of this study was to estimate the impact of voxelotor on the burden of SCD in France using a modeling approach, accounting for its anticipated adoption and diffusion over the next 5 years. We designed a sequential multi-cohort model to project and compare the cumulative incidence of SCD complications over a 20-year time horizon in a world with and without voxelotor. A distribution of patients was simulated across various levels of Hb response based on the phase 3 HO PE trial results, and relative risk reduction was adjusted using published meta-analysis results that projected risk reduction due to a 1 g/dL in...
Source: PLoS One - September 13, 2023 Category: Biomedical Science Authors: Fr édéric Galacteros Source Type: research

Accuracy of Video-Based Gait Analysis Using Pose Estimation during Treadmill Walking Versus Overground Walking in Persons after Stroke
CONCLUSIONS: Video-based gait analysis using pose estimation provides accurate measurements of step length, step time, and hip and knee kinematics during overground and treadmill walking in persons after stroke. Generally, sagittal videos of overground gait provide the most accurate results.IMPACT: Many clinicians lack access to expensive gait analysis tools that can help identify patient-specific gait deviations and guide therapy decisions. These findings show that video-based methods that require only common household devices provide accurate measurements of a variety of gait parameters in persons after stroke and could ...
Source: Physical Therapy - September 8, 2023 Category: Physiotherapy Authors: Kristen John Jan Stenum Cheng-Chuan Chiang Margaret A French Christopher Kim John Manor Matthew A Statton Kendra M Cherry-Allen Ryan T Roemmich Source Type: research

Botulinum toxin use in patients with post-stroke spasticity: a nationwide retrospective study from France
ConclusionOur analysis of the exhaustive PMSI database showed a suboptimal implementation of BoNT-A treatment recommendations in France. BoNT-A treatment initiation and re-administration are low, particularly in patients with post-stroke spasticity. Further investigations may help explain this observation, and may target specific actions to improve spasticity-related care pathway.
Source: Frontiers in Neurology - August 23, 2023 Category: Neurology Source Type: research

Thrombolysis and thrombectomy for stroke in octogenarians and nonagenarians: A regional observational study
DISCUSSION: IVT and MT improve early neurological recovery and functional outcome at discharge of both octogenarians and nonagenarians in current practice. Despite a poorer outcome for nonagenarians than octogenarians, these reperfusion treatments should not be withheld on the basis of age only.PMID:37596186 | DOI:10.1016/j.neurol.2023.03.023
Source: Revue Neurologique - August 18, 2023 Category: Neurology Authors: M Michelard O Detante O Heck S Marcel W Vadot G Gavazzi J Papassin Source Type: research

Assessment of Thoracic Endovascular Aortic Repair Using Relay Proximal Scallop: Results of a French Prospective Multicentre Study
CONCLUSION: One year outcomes showed that the Relay proximal scallop stent graft is an acceptable answer to aortic thoracic disease to deal with short proximal landing zones.PMID:37567339 | DOI:10.1016/j.ejvs.2023.08.002
Source: PubMed: Eur J Vasc Endovasc ... - August 11, 2023 Category: Surgery Authors: Lucie Derycke Jacques Tomasi Pascal Desgranges Francis Pesteil Didier Plissonier Mathieu Pernot Antoine Millon Robert Martinez Nabil Chakfe Jean-Marc Alsac Source Type: research

Distinct cardiovascular and cancer burdens associated with social position, work environment and unemployment: a cross-sectional and retrospective study in a large population-based French cohort
Conclusions Social position, work environment and unemployment are associated with distinct cardiovascular and cancerous diseases that could add up during lifetime, they should therefore be considered all together in any preventive strategy.
Source: BMJ Open - July 31, 2023 Category: General Medicine Authors: Sanchez Rico, M., Plessz, M., Airagnes, G., Ribet, C., Hoertel, N., Goldberg, M., Zins, M., Meneton, P. Tags: Open access, Epidemiology Source Type: research

E-007 CLEVER: clinical evaluation of WEB 0.017 device in intracranial aneurysms - final results for ruptured and unruptured aneurysm at 12 months
ConclusionThese results show good efficacy and safety results at 12 months month, and no WEB related mortality at 12 months. These data confirm the safety and efficacy of WEB 0.017 use in intracranial aneurysm treatment, unruptured as well as ruptured, and are consistent with the results published up to date.Disclosures L. Spelle: 1; C; Philips. 2; C; Microvention, Stryker, Medtronic, Balt, Phenox. C. Cognard: 2; C; Stryker, Medtronic, Mivi, Cerenovus, Microvention. I. Szikora: 2; C; Stryker, Cerenovus, Medtronic, Microvention, Brainomix. F. Wodarg: 2; C; Microvention, Stryker, Cerus Endovascular, Balt, Johnson & Johns...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Spelle, L., Cognard, C., Szikora, I., Wodarg, F., Costalat, V., Herbreteau, D., Fischer, S., Möhlenbruch, M., Papagiannaki, C., Klisch, J., Rautio, R., Berlis, A., Downer, J., Bester, M., Velasco, S., Liebig, T., Byrne, J., Pierot, L. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

Prospective observational study of stroke in Cayenne, Tours and Besan çon: The BECATOUR study
CONCLUSION: Despite some caveats, the profile of patients admitted for stroke in French Guiana is different from mainland France. The establishment of a stroke unit and an information campaign on the symptoms of stroke would allow better management.PMID:37487805 | DOI:10.1016/j.neurol.2023.02.068
Source: Revue Neurologique - July 24, 2023 Category: Neurology Authors: J Rhein G Charbonnier M Nacher M Gaudron T Moulin D R Rochemont J-P Cottier C Montagnac N Sabbah B de Toffol BECATOUR Study Group Source Type: research

Can Patent Foramen Ovales Cause Problems?
Discussion During fetal development, the heart primum and secundum septa grow and overlap leaving a small but important channel between the two atria. The foramen ovale is a flap valve moving blood from the right atrium into the left atrium directly and bypassing the high pressure pulmonary system. After birth and breathing air, the neonate’s lungs open up and the pulmonary vascular resistance decreases. The left atrium now has a relatively higher pressure than the right atria, and therefore pressure on the flap valve closes the foramen ovale. Usually within 6-12 months, the fusion of the primum and secundum of the f...
Source: PediatricEducation.org - July 24, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news