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Development and validation of a dementia risk score in the UK Biobank and Whitehall II cohorts
Background Current dementia risk scores have had limited success in consistently identifying at-risk individuals across different ages and geographical locations. Objective We aimed to develop and validate a novel dementia risk score for a midlife UK population, using two cohorts: the UK Biobank, and UK Whitehall II study. Methods We divided the UK Biobank cohort into a training (n=176 611, 80%) and test sample (n=44 151, 20%) and used the Whitehall II cohort (n=2934) for external validation. We used the Cox LASSO regression to select the strongest predictors of incident dementia from 28 candidate predictors and then dev...
Source: Evidence-Based Mental Health - August 21, 2023 Category: Psychiatry & Psychology Authors: Anatürk, M., Patel, R., Ebmeier, K. P., Georgiopoulos, G., Newby, D., Topiwala, A., de Lange, A.-M. G., Cole, J. H., Jansen, M. G., Singh-Manoux, A., Kivimäki, M., Suri, S. Tags: Open access, Press releases Old age psychiatry Source Type: research

Association of income and educational levels with adherence to direct oral anticoagulant therapy in patients with incident atrial fibrillation: A Finnish nationwide cohort study
In conclusion, we observed that income and ed ucational levels both have independent positive association on the implementation of DOAC therapy but no association on therapy persistence in patients with AF.
Source: Pharmacology Research and Perspectives - May 23, 2022 Category: Drugs & Pharmacology Authors: Konsta Teppo, Jussi Jaakkola, Fausto Biancari, Olli Halminen, Miika Linna, Jari Haukka, Jukka Putaala, Paula Tiili, Ossi Lehtonen, Mikko Niemi, Pirjo Mustonen, Janne Kinnunen, Juha Hartikainen, K. E. Juhani Airaksinen, Mika Lehto Tags: ORIGINAL ARTICLE Source Type: research

The nationwide Finnish anticoagulation in atrial fibrillation (FinACAF): study rationale, design, and patient characteristics
AbstractAtrial fibrillation (AF) is a major cause of ischemic stroke and the number of AF patients is increasing. Thus, up-to-date multifaceted data about the characteristics of AF patients, their treatments, and outcomes are urgently needed. The Finnish anticoagulation in atrial fibrillation (FinACAF) study has collected comprehensive data on all Finnish AF patients from 1st January 2004 to 31st December 2018. The aim of this paper is to describe the study rationale, the process of integrating data from the applied resources and to define the study cohort. Using national unique personal identification number, individual p...
Source: European Journal of Epidemiology - January 5, 2022 Category: Epidemiology Source Type: research

Clinical and Biochemical Signs of Polycystic Ovary Syndrome in Young Women Born Preterm
CONCLUSIONS: Women born preterm have a more hyperandrogenic hormonal profile, and those born LPT are approximately three times more likely at risk to have PCOS compared to women born at term.PMID:34081616 | DOI:10.1530/EJE-20-1462
Source: European Journal of Endocrinology - June 3, 2021 Category: Endocrinology Authors: Marika Paalanne Marja V ääräsmäki Sanna Mustaniemi Marjaana Tikanm äki Karoliina Wehkalampi Hanna-Maria Matinolli Johan Eriksson Marjo-Riitta Jarvelin Laure Morin-Papunen Eero Kajantie Source Type: research

Adjusted productivity costs of stroke by human capital and friction cost methods: a Northern Finland Birth Cohort 1966 study
ConclusionsThis study highlights the importance of adjustments of HCM and FCM. Routine register-based data can be used for accurate productivity cost estimates of health shocks.
Source: The European Journal of Health Economics - February 24, 2021 Category: Health Management Source Type: research

Periodontal Disease Is Associated With Increased Risk of Hypertension: A Cross-Sectional Study
Conclusion: Periodontal disease is significantly and positively correlated with increased risk of hypertension in Chinese population, and exact mechanisms of this association should be explored in future. Introduction Periodontal disease is a complex polymicrobial inflammation, including gingivitis and periodontitis. According to the 2015 Global Burden of Disease (GBD) study, the prevalence of severe chronic periodontitis in 2015 has reached 616 million (Kassebaum et al., 2017). In China, the periodontal disease standardized DALYs rate has risen from 24.7 in 1990 to 25.7 in 2013 according to the data from 2013 GBD ...
Source: Frontiers in Physiology - April 24, 2019 Category: Physiology Source Type: research

Harnessing the Four Elements for Mental Health
DiscussionAs detailed above, the “elements” in both a classical and a contemporary sense have effects on our mental health and are potentially modifiable aspects that can be harnessed as therapeutic interventions. The most robust interventional evidence currently available shows tentative support for several use of the elements via horticultural and nature-exposure therapy, green exercise/physical activity, sauna and heat therapy, balneotherapy, and breathing exercises. It should be noted that, in many cases, these interventions were not studied in definitive diagnosed psychiatric disorders and thus it is pre...
Source: Frontiers in Psychiatry - April 23, 2019 Category: Psychiatry Source Type: research

Loneliness Can Actually Hurt Your Heart. Here ’s Why
Research has shown, again and again, that emotional and physical health are inextricably linked. There are significant health benefits associated with love and friendship, supportive marriages and feelings of gratitude, for example. And there are significant health risks linked to the opposite. A new study, published Monday in the journal Heart, looked at social isolation (being separated from other people) and loneliness (being cut off from social connection, and being unhappy about it). Researchers found that people who are socially isolated or lonely are more likely to have a heart attack or stroke, compared to people w...
Source: TIME: Health - March 26, 2018 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized healthytime onetime Research Source Type: news

Atrial fibrillation in immigrant groups: a cohort study of all adults 45  years of age and older in Sweden
In conclusion, we observed substantial differences in incidence of AF between immigrant groups and the Swedish-born population. A greater awareness of the increased risk of AF development in some immigrant groups may enable for a timely diagnos is, treatment and prevention of its debilitating complications, such as stroke.
Source: European Journal of Epidemiology - July 12, 2017 Category: Epidemiology Source Type: research

Cohort profile: the Finnish Medication and Alzheimer's disease (MEDALZ) study
Purpose The aim of the Medicine use and Alzheimer's disease (MEDALZ) study is to investigate the changes in medication and healthcare service use among persons with Alzheimer's disease (AD) and to evaluate the safety and effectiveness of medications in this group. This is important, because the number of persons with AD is rapidly growing and even though they are a particularly vulnerable patient group, the number of representative, large-scale studies with adequate follow-up time is limited. Participants MEDALZ contains all residents of Finland who received a clinically verified diagnosis of AD between 2005 and 2011 and ...
Source: BMJ Open - July 12, 2016 Category: Journals (General) Authors: Tolppanen, A.-M., Taipale, H., Koponen, M., Lavikainen, P., Tanskanen, A., Tiihonen, J., Hartikainen, S. Tags: Open access, Epidemiology, Neurology, Pharmacology and therapeutics Cohort profile Source Type: research