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Total 15 results found since Jan 2013.

PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation
CONCLUSIONS: Patients with AF exhibit increased levels of PPP1R12C protein compared with controls. PPP1R12C overexpression in mice increases PP1c targeting to MLC2a and causes MLC2a dephosphorylation, which reduces atrial contractility and increases AF inducibility. These findings suggest that PP1 regulation of sarcomere function at MLC2a is a key determinant of atrial contractility in AF.PMID:37737016 | DOI:10.1161/CIRCRESAHA.123.322516
Source: Circulation Research - September 22, 2023 Category: Cardiology Authors: Srikanth Perike Francisco J Gonzalez-Gonzalez Issam Abu-Taha Frederick W Damen Laurin M Hanft Ken S Lizama Anahita Aboonabi Andrielle E Capote Yuriana Aguilar-Sanchez Benjamin Levin Zhenbo Han Arvind Sridhar Jacob Grand Jody Martin Joseph G Akar Chad M Wa Source Type: research

Po-05-136 in stroke patients, do baseline electrocardiogram findings correlate with diagnostic findings on long-term monitoring with implantable loop recorder?
In patients with cryptogenic stroke, long-term monitoring is standard-of-care to exclude atrial tachyarrhythmias. Prior studies have not examined interatrial block (IAB) and other ECG markers paired with long-term continuous monitoring (the current gold standard) to predict likelihood of atrial fibrillation (AF) detection in stroke patients.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Matthew D. Henriques, Chad Gier, Mohammed Al-Sadawi, Faisal Aslam, Abhijeet Singh, Ibrahim O. Almasry, Eric J. Rashba, Roger Fan Source Type: research

Eliminating Medication Copayments for Low-income Older Adults at High Cardiovascular Risk: A Randomized Controlled Trial
Conclusions: In low-income adults at high cardiovascular risk, eliminating copayments (average $35 a month) did not improve clinical outcomes or reduce healthcare costs, despite a modest improvement in adherence to medications.PMID:36871215 | DOI:10.1161/CIRCULATIONAHA.123.064188
Source: Circulation - March 5, 2023 Category: Cardiology Authors: David J T Campbell Chad Mitchell Brenda R Hemmelgarn Marcello Tonelli Peter Faris Jianguo Zhang Ross T Tsuyuki Jane Fletcher Flora Au Scott Klarenbach Derek V Exner Braden J Manns Interdisciplinary Chronic Disease Collaboration Source Type: research

Self-management Support Using Advertising Principles for Older Low Income Adults at High Cardiovascular Risk: a Randomized Controlled Trial
Conclusions: In low-income older adults, a tailored SMES program using advertising principles reduced the rate of clinical outcomes compared with usual care, though the mechanisms of improvement are unclear and further studies are required.PMID:36871212 | DOI:10.1161/CIRCULATIONAHA.123.064189
Source: Circulation - March 5, 2023 Category: Cardiology Authors: David J T Campbell Marcello Tonelli Brenda R Hemmelgarn Peter Faris Jianguo Zhang Flora Au Ross T Tsuyuki Chad Mitchell Raj Pannu Tavis Campbell Noah Ivers Jane Fletcher Derek V Exner Braden J Manns Interdisciplinary Chronic Disease Collaboration Source Type: research

Questions Regarding a Recent Study Comparing Mitral Regurgitant Volume Between Proximal Flow Convergence and Volumetric Methods: The Importance of Sex Differences
Congratulations to Altes et al.1 on their important publication comparing mitral regurgitant volume by magnetic resonance imaging (MRI) to echocardiography-derived proximal isovelocity surface area and volumetric regurgitant volume (biplane stroke volume – Doppler stroke volume) data. The biplane data correspond very well with the MRI data. Several of the current authors were part of a 2018 publication comparing mitral regurgitant volume using automated three-dimensional (3D) echocardiography stroke volume data and Doppler stroke volume with mitral regurgitant volume from MRI, which closely correlated with MRI.
Source: Journal of the American Society of Echocardiography - April 8, 2022 Category: Cardiology Authors: Chad M. House, William B. Nelson Source Type: research

Relation of Cardiovascular Risk Factors to Mortality and Cardiovascular Events in Hospitalized Patients with Coronavirus Disease 2019 (From the Yale COVID-19 Cardiovascular Registry)
Individuals with established cardiovascular disease or a high burden of cardiovascular risk factors may be particularly vulnerable to develop complications from coronavirus disease 2019 (COVID-19). We conducted a prospective cohort study at a tertiary care center to identify risk factors for in-hospital mortality and major adverse cardiovascular events (MACE; a composite of myocardial infarction, stroke, new acute decompensated heart failure, venous thromboembolism, ventricular or atrial arrhythmia, pericardial effusion, or aborted cardiac arrest) among consecutively hospitalized adults with COVID-19, using multivariable b...
Source: The American Journal of Cardiology - February 1, 2021 Category: Cardiology Authors: Manan Pareek, Avinainder Singh, Lina Vadlamani, Maxwell Eder, Justin Pacor, Jakob Park, Zaniar Ghazizadeh, Alex Heard, Ana Sofia Cruz-Solbes, Roozbeh Nikooie, Chad Gier, Zain V. Ahmed, James V. Freeman, Judith Meadows, Kim G.E. Smolderen, Rachel Lampert, Source Type: research

Transcatheter aortic valve replacement for patients with severe bicuspid aortic stenosis
ConclusionsThis initial experience suggests TAVR can be safely performed in patients with BAV achieving similar short-term procedural and clinical outcomes when compared with patients with TAV.Condensed AbstractThe outcomes of 50 patients (8.8%) with bicuspid aortic stenosis (BAV) undergoing TAVR were compared with those of 517 patients (91.2%) with trileaflet aortic valve (TAV) stenosis. Patients with BAV were younger, had higher prevalence of COPD, lower prevalence of CAD, higher BMI and lower STS score. Major complications were similar between the groups, including stroke (2.0% vs. 1.5, P = .567), 30-day all-c...
Source: American Heart Journal - February 9, 2020 Category: Cardiology Source Type: research

Safety and efficacy of zero fluoroscopy transseptal puncture with different approaches
ConclusionTransseptal puncture can be safely and effectively performed without the need for fluoroscopy.This article is protected by copyright. All rights reserved
Source: Pacing and Clinical Electrophysiology : PACE - November 16, 2019 Category: Cardiology Authors: Tina Baykaner, Ken Quadros, Amit Thosani, Babak Yasmeh, Raman Mitra, Emerson Liu, William Belden, Zhigang Liu, Alex Costea, Chad Brodt, Paul Zei Tags: ELECTROPHYSIOLOGY Source Type: research

Neck circumference and cardiovascular outcomes: Insights from the Jackson heart study
ConclusionsIn this large cohort of African American individuals, a larger NC was associated with increased risk for HF hospitalization following adjustment for age and sex, but this risk was not statistically significant after adjusting for other clinical variables. Although NC is not independently associated with increased risk for cardiovascular events, it may offer prognostic information particularly related to HF hospitalization.
Source: American Heart Journal - March 9, 2019 Category: Cardiology Source Type: research

Differences in statin utilization and lipid lowering by race, ethnicity, and HIV status in a real-world cohort of persons with human immunodeficiency virus and uninfected persons
ConclusionsAmong PWH with statin indication(s), blacks and Hispanics were less likely than whites to have been prescribed a statin. These racial/ethnic disparities were less pronounced among uninfected persons. There were significant differences in type of statin used for PWH compared to uninfected matched controls. Future efforts addressing disparities in CVD prevention among PWH are warranted.
Source: American Heart Journal - January 25, 2019 Category: Cardiology Source Type: research

Differences in Statin Utilization and Lipid-Lowering by Race, Ethnicity, and HIV Status in a Real-World Cohort of Persons with Human Immunodeficiency Virus and Uninfected Persons
ConclusionsAmong PWH with statin indication(s), Blacks and Hispanics were less likely than whites to have been prescribed a statin. These racial/ethnic disparities were less pronounced among uninfected persons. There were significant differences in type of statin utilized for PWH compared to uninfected matched controls. Future efforts addressing disparities in CVD prevention among PWH are warranted.
Source: American Heart Journal - December 21, 2018 Category: Cardiology Source Type: research

Relation of Carotid Intima-Media Thickness to Cardiovascular Events in Black Americans (From the Jackson Heart Study)
Although several prospective studies have reported independent relationships between carotid intima-media thickness (CIMT) and risk of incident cardiovascular diseases (CVD) among primarily non-African American (AA) cohorts, the utility of CIMT values for the prediction of incident coronary heart disease and stroke events in blacks remain unclear. At the baseline examination (2000 –2004) of the Jackson Heart Study (JHS), AA adults 21-94 years of age (mean 54) underwent bilateral far-wall CIMT measurement (mean 0.76 mm).
Source: The American Journal of Cardiology - July 31, 2017 Category: Cardiology Authors: Todd C. Villines, Lucy L. Hsu, Chad Blackshear, Cheryl R. Nelson, Michael Griswold Source Type: research

Factors associated with stroke in patients with paroxysmal atrial fibrillation beyond CHADS2 score.
CONCLUSIONS: Elevated E velocity, E/E' and SD of tA-SR were associated with occurrence of stroke in patients with PAF even with similar CHAD scores. Increased SD of tA-SR and E/E' were independently associated with stroke in patients with PAF. PMID: 27296157 [PubMed - as supplied by publisher]
Source: Cardiology Journal - June 13, 2016 Category: Cardiology Authors: Kang MK, Han C, Chun KJ, Choi J, Choi S, Cho JR, Lee N Tags: Cardiol J Source Type: research