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HDL cholesterol is a protective predictor in the development and progression of retinopathy in type 1 diabetes: a 15-year follow-up study
Despite the declining trend of new visual impairment and blindness due to diabetes in developed countries by the increasing use of anti-vascular endothelial growth factor (anti-VEGF) agents and telemedicine implementation in its systematic screening over the past decade [1,2], diabetic retinopathy (DR), a common and specific microvascular complication of diabetes, is still the leading cause of blindness in patients with type 1 diabetes (T1DM) and also related to increased risk of life-threatening systemic vascular complications, including stroke, coronary heart disease, and heart failure [3,4,5].
Source: Diabetes Research and Clinical Practice - March 2, 2022 Category: Endocrinology Authors: Martina Tomi ć, Romano Vrabec, Tomislav Bulum, Spomenka Ljubić Source Type: research

Cell Therapy for Critical Limb Ischemia: Advantages, Limitations, and New Perspectives for Treatment of Patients with Critical Diabetic Vasculopathy
AbstractPurpose of ReviewTo provide a highlight of the current state of cell therapy for the treatment of critical limb ischemia in patients with diabetes.Recent FindingsThe global incidence of diabetes is constantly growing with consequent challenges for healthcare systems worldwide. In the UK only, NHS costs attributed to diabetic complications, such as peripheral vascular disease, amputation, blindness, renal failure, and stroke, average £10 billion each year, with cost pressure being estimated to get worse. Although giant leaps forward have been registered in the scope of early diagnosis and optimal glycaemic control,...
Source: Current Diabetes Reports - March 2, 2021 Category: Endocrinology Source Type: research

Risk Prediction of the Diabetes Missing Million: Identifying Individuals at High Risk of Diabetes and Related Complications
AbstractEarly diagnosis and effective management of type  2 diabetes (T2D) are crucial in reducing the risk of developing life-changing complications such as heart failure, stroke, kidney disease, blindness and amputation, which are also associated with significant costs for healthcare providers. However, as T2D symptoms often develop slowly it is not un common for people to live with T2D for years without being aware of their condition—commonly known as the undiagnosed missing million. By the time a diagnosis is received, many individuals will have already developed serious complications. While the existence of undiagn...
Source: Diabetes Therapy - November 14, 2020 Category: Endocrinology Source Type: research

Evaluation of health utility values for diabetic complications, treatment regimens, glycemic control and other subjective symptoms in diabetic patients using the EQ-5D-5L
ConclusionsThe utility decrement related to each diabetic complication varied with its severity and accompanying symptoms. Complex treatment regimens were independently associated with lower utility values. The utility decrement associated with diabetic complication and complex treatment regimens would be overestimated in the analysis without adjustment for glycemic control or other subjective symptoms.
Source: Acta Diabetologica - October 23, 2018 Category: Endocrinology Source Type: research

Modelling incremental benefits on complications rates when targeting lower HbA1c levels in people with Type 2 diabetes and cardiovascular disease
ConclusionsThese simulated complication rates might help inform the degree to which complications might be reduced by targeting particular HbA1c reductions in Type 2 diabetes.This article is protected by copyright. All rights reserved.
Source: Diabetic Medicine - October 23, 2017 Category: Endocrinology Authors: S. A. Mostafa, R. L. Coleman, O. F. Agbaje, A. M. Gray, R. R. Holman, M. A. Bethel Tags: Research Article Source Type: research

Considerations for management of patients with diabetic macular edema: optimizing treatment outcomes and minimizing safety concerns through interdisciplinary collaboration
Diabetes is one of the leading causes of premature blindness in the world [1 –3]. A key contributing factor to this is inadequate glycemic control [4,5]; despite the advent of multiple new agents to treat hyperglycemia, with lower risk of weight gain and hypoglycemia than previous treatments, many people with diabetes are not meeting their glycemic targets [6,7]. This incr eases the risk of developing serious comorbidities, such as cardiovascular disease, stroke, nephropathy, and neuropathy [2,8,9].
Source: Diabetes Research and Clinical Practice - January 28, 2017 Category: Endocrinology Authors: W David Strain, Xavier Cos, Christian Pr ünte Tags: Review Source Type: research

Updated NICE guidelines on the management of type 2 diabetes in adults
Updated NICE guidelines stress the need for individualising care for people with type 2 diabetes, and include new recommendations on managing blood glucose, effective drug treatments and lifestyle interventions. The vast majority of people who have diabetes have type 2 diabetes, a form of the condition that tends to appear in people over 40, but that is increasingly being seen in younger people due to rising obesity levels. The condition is also common among people from people from African, African Caribbean and South Asian family origins. It can result in blindness, kidney failure, premature heart disease strok...
Source: Society for Endocrinology - December 2, 2015 Category: Endocrinology Source Type: news

Social Determinants of Health in Adults with Type 2 Diabetes–Contribution of Mutable and Immutable Factors
Type 2 diabetes affects more than 29 million people in the US, with an estimated 8.1 million individuals having undiagnosed type 2 diabetes and an estimated 86 million Americans diagnosed with prediabetes [1]. In 2012, costs associated with type 2 diabetes totaled $245 billion, including direct and indirect costs [1]. The remarkable cost of type 2 diabetes can be attributed to various complications and comorbid conditions associated with this chronic illness, including hypo- and hyperglycemia, high blood pressure, high LDL cholesterol, heart disease, stroke, blindness, kidney disease, and amputations [1].
Source: Diabetes Research and Clinical Practice - September 17, 2015 Category: Endocrinology Authors: Rebekah J. Walker, Brittany L. Smalls, Leonard E. Egede Source Type: research

Social determinants of health in adults with type 2 diabetes—Contribution of mutable and immutable factors
Type 2 diabetes affects more than 29 million people in the US, with an estimated 8.1 million individuals having undiagnosed type 2 diabetes and an estimated 86 million Americans diagnosed with prediabetes [1]. In 2012, costs associated with type 2 diabetes totaled $245 billion, including direct and indirect costs [1]. The remarkable cost of type 2 diabetes can be attributed to various complications and comorbid conditions associated with this chronic illness, including hypo- and hyperglycemia, high blood pressure, high LDL cholesterol, heart disease, stroke, blindness, kidney disease, and amputations [1].
Source: Diabetes Research and Clinical Practice - September 17, 2015 Category: Endocrinology Authors: Rebekah J. Walker, Brittany L. Smalls, Leonard E. Egede Source Type: research

A Review of the Mental Health Issues of Diabetes Conference.
Abstract Individuals with type 1 diabetes are at increased risk for depression, anxiety disorder, and eating disorder diagnoses. People with type 1 diabetes are also at risk for subclinical levels of diabetes distress and anxiety. These mental/behavioral health comorbidities of diabetes are associated with poor adherence to treatment and poor glycemic control, thus increasing the risk for serious short- and long-term physical complications, which can result in blindness, amputations, stroke, cognitive decline, decreased quality of life, as well as premature death. When mental health comorbidities of diabetes are n...
Source: Diabetes Care - January 28, 2015 Category: Endocrinology Authors: Ducat L, Rubenstein A, Philipson LH, Anderson BJ Tags: Diabetes Care Source Type: research

Impact of diabetes‐related complications on healthcare costs: new results from the UK Prospective Diabetes Study
ConclusionsDiabetic complications are associated with substantial immediate and long‐term healthcare costs. Our comprehensive new estimates of these costs, derived from detailed recent UK Prospective Diabetes Study post‐trial data, should aid researchers and health policy analyses.This article is protected by copyright. All rights reserved.
Source: Diabetic Medicine - November 29, 2014 Category: Endocrinology Authors: M. L. Alva, A. Gray, B. Mihaylova, J. Leal, R. R. Holman Tags: Research Article Source Type: research

The impact of diabetes‐related complications on healthcare costs: new results from the UKPDS (UKPDS 84)
ConclusionsDiabetic complications are associated with substantial immediate and long‐term healthcare costs. Our comprehensive new estimates of these costs, derived from detailed recent UK Prospective Diabetes Study post‐trial data, should aid researchers and health policy analyses.This article is protected by copyright. All rights reserved.
Source: Diabetic Medicine - November 29, 2014 Category: Endocrinology Authors: M. L. Alva, A. Gray, B. Mihaylova, J. Leal, R. R. Holman Tags: Research Article Source Type: research

Pulse wave reflection is associated with diabetes duration, albuminuria and cardiovascular disease in type 1 diabetes
Conclusions In type 1 diabetes, augmentation pressure and heart rate-adjusted augmentation index were associated with diabetes duration, albuminuria, and CVD, independently of conventional risk factors. ClinicalTrials.gov:NCT01171248.
Source: Acta Diabetologica - October 2, 2014 Category: Endocrinology Source Type: research

February Partner Spotlight
The Texas Diabetes Prevention and Control Program Incorporates NDEP Messages and Materials in its “Get Tested Today” Campaign The Texas Diabetes Prevention and Control Program (DPCP) at the Texas Department of State Health Services administers grant-funded initiatives and contracted services to address current issues affecting people with diabetes and those at risk of getting diabetes. The Texas DPCP maintains a statewide system of quality education services for all people with diabetes and health care professionals who offer diabetes treatment and educa...
Source: National Diabetes Education Program - January 31, 2014 Category: Endocrinology Source Type: news