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Effectiveness and safety of oral anticoagulants for non-valvular atrial fibrillation: a population-based cohort study in primary healthcare in Catalonia
Conclusion: Being men, a previous event and DOAC-switch posed a higher risk for all study outcomes. direct oral anticoagulants had a protective effect against cerebral bleeding in comparison to vitamin K antagonists. Adherence to direct oral anticoagulants resulted in lower risk of stroke and cerebral bleeding. We found no differences in the risk of stroke and gastrointestinal bleeding when we compared direct oral anticoagulants vs. vitamin K antagonists.
Source: Frontiers in Pharmacology - September 15, 2023 Category: Drugs & Pharmacology Source Type: research

An interrupted time series study of electronic health record clinical decision support for providers caring for patients with atrial fibrillation at increased stroke risk
CONCLUSION: There was a significant trend of increasing anticoagulation rates during the pre-BPA period, with no significant change in trend during the post-BPA period relative to the pre-BPA period.PMID:37696764 | DOI:10.1093/ajhp/zxad188
Source: American Journal of Health-System Pharmacy : AJHP - September 11, 2023 Category: Drugs & Pharmacology Authors: Andrew J Osterland Marie Yasuda Robert J Widmer Anthony C Colavecchia Tyler Gums Birol Emir Kim Nolen Elizabeth MacLean Paul J Godley Source Type: research

Associations of Apixaban Dose With Safety and Effectiveness Outcomes in Patients With Atrial Fibrillation and Severe Chronic Kidney Disease
CONCLUSIONS: Compared with 2.5 mg, use of 5 mg apixaban was associated with a higher risk of bleeding in patients with atrial fibrillation and severe chronic kidney disease, with no difference in the risk of stroke/systemic embolism or death, supporting the apixaban dosing recommendations on the basis of kidney function by the European Medicines Agency, which differ from those issued by the US Food and Drug Administration.PMID:37681341 | DOI:10.1161/CIRCULATIONAHA.123.065614
Source: Circulation - September 8, 2023 Category: Cardiology Authors: Yunwen Xu Alex R Chang Lesley A Inker Mara McAdams-DeMarco Morgan E Grams Jung-Im Shin Source Type: research

Can a best practice advisory improve anticoagulation prescribing to reduce stroke risk in patients with atrial fibrillation?
CONCLUSIONS: A BPA added to an AF decision support tool improved anticoagulation therapy among AF patients in a primary care academic health system setting.PMID:37579873 | DOI:10.1016/j.jjcc.2023.08.005
Source: Journal of Cardiology - August 14, 2023 Category: Cardiology Authors: Mark H Eckman Ruth Wise Carol Knochelmann Rachael Mardis Anthony C Leonard Sharon Wright Ashish Gummadi Estrelita Dixon Richard C Becker Daniel P Schauer Matthew L Flaherty Alexandru Costea Dawn Kleindorfer Rob Ireton Pete Baker Brett M Harnett Adeboye Ad Source Type: research

Prediction of short-term atrial fibrillation risk using primary care electronic health records
Conclusions FIND-AF, a machine learning algorithm applicable at scale in routinely collected primary care data, identifies people at higher risk of short-term AF.
Source: Heart - June 26, 2023 Category: Cardiology Authors: Nadarajah, R., Wu, J., Hogg, D., Raveendra, K., Nakao, Y. M., Nakao, K., Arbel, R., Haim, M., Zahger, D., Parry, J., Bates, C., Cowan, C., Gale, C. P. Tags: Open access, Editor's choice Arrhythmias and sudden death Source Type: research

A Real-World Evaluation of Primary Medication Nonadherence in Patients with Nonvalvular Atrial Fibrillation Prescribed Oral Anticoagulants in the United States
ConclusionsMore than one-quarter of patients experienced PMN within 30 days of their initial prescription order. This rate decreased over a longer period, suggesting a delay in fills. Understanding the factors associated with PMN is warranted to develop effective interventions for improving OAC treatment rates in NVAF.
Source: American Journal of Cardiovascular Drugs - June 10, 2023 Category: Cardiology Source Type: research

Epilepsy-Heart Syndrome: Incidence and Clinical Outcomes of Cardiac Complications in patients with Epilepsy
CONCLUSIONS: The large proportions of PWE with active disease that experience CVEs and the poor long-term outcome associated suggest the existence of an 'epilepsy-heart syndrome'.PMID:37295636 | DOI:10.1016/j.cpcardiol.2023.101868
Source: Epilepsy Curr - June 9, 2023 Category: Neurology Authors: Tommaso Bucci Gashirai K Mbizvo Jos é Miguel Rivera-Caravaca Josephine Mayer Anthony G Marson Azmil H Abdul-Rahim Gregory Y H Lip Source Type: research

Outcome of transcatheter atrial septal defect closure in a nationwide cohort
CONCLUSION: After TC closure of ASD, patients had a higher risk of new-onset atrial fibrillation and migraine than controls without ASD. As novel findings, we found an increased risk for ischemic heart disease, AV conduction disorders, and ventricular fibrillation/tachycardia.Key messagesEven though patients have an excellent overall prognosis after percutaneous ASD closure, the increased incidence of major comorbidities like atrial fibrillation and heart failure prompts more thorough lifelong follow-up.This study's novel findings revealed the increased risk for ischemic heart disease, AV conduction disorders, or ventricul...
Source: Annals of Medicine - February 14, 2023 Category: Internal Medicine Authors: V Muroke M Jalanko J Haukka J Hartikainen A Tahvanainen H Ukkonen K Ylitalo J Pihkala J Sinisalo Source Type: research

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