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Stroke type and severity in patients with subclinical atrial fibrillation: An analysis from the Asymptomatic Atrial Fibrillation and Stroke Evaluation in Pacemaker Patients and the Atrial Fibrillation Reduction Atrial Pacing Trial (ASSERT)
Conclusions In patients with SCAF and stroke, SCAF seems probably causal in many cases; however, in more than 40%, it seems to be acting only as a risk marker.
Source: American Heart Journal - June 15, 2018 Category: Cardiology Source Type: research

Worse Outcome in Patients with Acute Stroke and Atrial Fibrillation Following Thrombolysis.
CONCLUSIONS: Our study suggests worse outcome in thrombolized patients with AF compared to non-AF stroke patients. Therefore, AF itself can be a poor prognostic factor for tPA sensitivity regarding the chance of revascularization and recovery after intravenous tPA. PMID: 28513116 [PubMed - in process]
Source: The Israel Medical Association Journal - May 18, 2017 Category: General Medicine Tags: Isr Med Assoc J Source Type: research

Pre admission treatment with Beta ‐blockers in hypertensive patients with acute stroke and 3‐month outcome—Data from a national stroke registry
In conclusion, treatment with BB is not associated with 3‐month poor outcome in hypertensive patients.
Source: The Journal of Clinical Hypertension - March 9, 2018 Category: Cardiology Authors: Yoav Eizenberg, Ehud Grossman, David Tanne, Silvia Koton Tags: ORIGINAL PAPER Source Type: research

XANTUS-EL: A real-world, prospective, observational study of patients treated with rivaroxaban for stroke prevention in atrial fibrillation in Eastern Europe, Middle East, Africa and Latin America
ConclusionsXANTUS-EL confirmed low stroke and major bleeding rates in patients with NVAF from EEMEA and Latin America. The population was younger but with more heart failure and hypertension than XANTUS; stroke/SE rate was similar but major bleeding lower.
Source: The Egyptian Heart Journal - October 5, 2018 Category: Cardiology Source Type: research

Stroke and bleeding risks in patients with atrial fibrillation treated with reduced apixaban dose: a real life study.
Abstract Our objective was to assess the association between reduced apixaban dose and two outcomes: ischemic stroke/systemic embolism (SE) and major bleeding. We performed a retrospective cohort study within the database of the largest healthcare provider in Israel. We identified all patients diagnosed with atrial fibrillation, who started apixaban treatment between 2013 and 2017. Apixaban users were classified into three dosing regimen groups based on their renal function, age and weight: standard dose (5 mg bid), adjusted reduced dose (2.5 mg bid), and underdosing (2.5 mg bid). Patients were followed through 2...
Source: Clinical Pharmacology and Therapeutics - June 18, 2020 Category: Drugs & Pharmacology Authors: Salameh M, Gronich N, Stein N, Kotler A, Rennert G, Auriel E, Saliba W Tags: Clin Pharmacol Ther Source Type: research

Detection of atrial fibrillation in patients with embolic stroke of undetermined source by prolonged monitoring with implantable loop recorders.
In conclusion, AF can be documented in approximately 25 % of patients with the diagnosis of ESUS after careful work-up within a year of monitoring by an ILR and daily remote interrogation. This had important therapeutic consequences (initiation of anticoagulation for secondary stroke prevention) in these patients. PMID: 28862284 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - September 1, 2017 Category: Hematology Authors: Israel C, Kitsiou A, Kalyani M, Deelawar S, Ejangue LE, Rogalewski A, Hagemeister C, Minnerup J, Schäbitz WR Tags: Thromb Haemost Source Type: research

Atrial fibrillation in patients with embolic stroke of undetermined source during 3 years of prolonged monitoring with an implantable loop recorder.
CONCLUSIONS: In ESUS patients, early implantation of an ILR with cardiac monitoring and remote transmission over a 3-year period detects AF in 41.4 % and results in oral anticoagulation in 82% of these patients. PMID: 33401327 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - January 5, 2021 Category: Hematology Authors: Kitsiou A, Rogalewski A, Kalyani M, Deelawar S, Tribunyan S, Greeve I, Minnerup J, Israel C, Schäbitz W Tags: Thromb Haemost Source Type: research

Safety Signal Evaluation of a Risk of Syncope and Dizziness Not Related to Bleeding or Stroke in Direct Oral Anticoagulant-Treated Patients
Clin Ther. 2023 Jan 16:S0149-2918(22)00416-7. doi: 10.1016/j.clinthera.2022.12.010. Online ahead of print.ABSTRACTPURPOSE: In clinical studies, rivaroxaban treatment has been associated with increased incidence of syncope not related to bleeding, anemia, or stroke. The study objective was to evaluate the occurrence of dizziness and/or syncope not related to bleeding, anemia, or stroke in patients treated with direct oral anticoagulants (DOACs).METHODS: A retrospective, observational, comparative study of adult patients diagnosed with atrial fibrillation and treated with DOACs was conducted using digital retrieval of medica...
Source: Clinical Therapeutics - January 18, 2023 Category: Drugs & Pharmacology Authors: Ophir Lavon Daisy Cohen Source Type: research

Comparison of Stroke Risk Stratification Scores for Atrial Fibrillation
Several stroke risk stratification scores have been developed to guide clinical decision making in patients with non valvular atrial fibrillation (AF). The aim of this study was to compare the performance of the CHADS2, CHA2DS2-VASc and R2CHADS2 risk scores to predict stroke.This retrospective cohort study was based on electronic medical records from Clalit Health Services (CHS), the largest payer provider healthcare organization in Israel. Data of CHS members with AF diagnosis between 2004- 2015 were extracted.
Source: The American Journal of Cardiology - March 12, 2019 Category: Cardiology Authors: Meytal Avgil Tsadok, Adi Berliner Senderey, Orna Reges, Morton Leibowitz, Maya Leventer-Roberts, Moshe Hoshen, Moti Haim Source Type: research

In-thrombus thrombin secretion: a new diagnostic marker of atrial fibrillation in cryptogenic stroke
Isr Med Assoc J. 2022 Dec 1;25(12):853-854.ABSTRACTEndovascularly retrieved clots may be a potential resource for diagnosing stroke etiology. This method may influence secondary prevention treatment. We measure thrombin activity eluted by serially washing clots. We concluded that an assay measuring the change in thrombin in clots retrieved during acute stroke endovascular thrombectomy procedures may serve as a diagnostic marker of the origin of the clot. The suggested mechanism for these differences may be the clot location before its retrieval, with high blood flow causing thrombin washout in atherosclerotic clots, in con...
Source: The Israel Medical Association Journal - August 16, 2023 Category: General Medicine Authors: Ze'ev Itsekson Hayosh Eiman Abu Bandora Natalia Shelestovich Maya Nulman Mati Bakon Gal Yaniv Boris Khaitovitch Shmuel Balan Alexandra Gerasimova Tali Drori Stefan Mausbach Yvonne Schwammenthal Arnon Afek Joab Chapman Efrat Shavit Stein David Orion Source Type: research

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