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Condition: Antiphospholipid Syndrome

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Total 523 results found since Jan 2013.

Antiphospholipid Antibodies and the Risk of Stroke in Urban and Rural Tanzania: A Community-Based Case-Control Study Clinical Sciences
Conclusions— The presence of lupus anticoagulant is a strong, and to date unrecognized, risk factor for stroke in Tanzania, especially in young and middle-aged individuals.
Source: Stroke - September 25, 2016 Category: Neurology Authors: de Mast, Q., Molhoek, J. E., van der Ven, A. J., Gray, W. K., de Groot, P. G., Jusabani, A., Mugusi, F., Urbanus, R. T., Walker, R. W. Tags: Etiology, Mechanisms, Pathophysiology, Cerebrovascular Disease/Stroke, Ischemic Stroke Clinical Sciences Source Type: research

Incidence of Ischemic Stroke in Young Adults, a 4 Year Retrospective Review from an Urban Tertiary Care Center in North Philadelphia (P3.232)
Conclusions: The incidence of Ischemic Stroke in this cohort is much higher than that reported in other observational studies. Despite an extensive work up, a cause was not found in the majority of patients. These data support the need for a more in depth investigation of the causes of stroke in the young in urban, underserved communities. Standard of care diagnostic tests fail to explain the unusually high incidence of Ischemic Stroke in this cohort.Disclosure: Dr. Pirastehfar has nothing to disclose. Dr. Katz has nothing to disclose. Dr. Gentile has nothing to disclose. Dr. Jacobi has nothing to disclose. Dr. Linares has...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Pirastehfar, M., Katz, P., Gentile, N., Jacobi, J., Linares, G. Tags: Stroke in the Young Source Type: research

Prothrombotic States and Ischemic Stroke in the Young (P3.231)
Conclusions: There is no association between prothrombotic risk factors (analyzed individually or as a group) and idiopathic ischemic stroke in the young, even in those with a PFO or with migraine.Disclosure: Dr. Boudjani has nothing to disclose. Dr. Lanthier has received compensation for activities with Bristol-Myers-Squibb, Sanofi-Aventis, Boehringer-Ingelheim, and Astra-Zeneca as a speaker.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Boudjani, H., Lanthier, S. Tags: Stroke in the Young Source Type: research

Guidelines for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association AHA/ASA Guideline
The aim of this updated guideline is to provide comprehensive and timely evidence-based recommendations on the prevention of future stroke among survivors of ischemic stroke or transient ischemic attack. The guideline is addressed to all clinicians who manage secondary prevention for these patients. Evidence-based recommendations are provided for control of risk factors, intervention for vascular obstruction, antithrombotic therapy for cardioembolism, and antiplatelet therapy for noncardioembolic stroke. Recommendations are also provided for the prevention of recurrent stroke in a variety of specific circumstances, includi...
Source: Stroke - June 23, 2014 Category: Neurology Authors: Kernan, W. N., Ovbiagele, B., Black, H. R., Bravata, D. M., Chimowitz, M. I., Ezekowitz, M. D., Fang, M. C., Fisher, M., Furie, K. L., Heck, D. V., Johnston, S. C., Kasner, S. E., Kittner, S. J., Mitchell, P. H., Rich, M. W., Richardson, D., Schwamm, L. H Tags: AHA Statements and Guidelines AHA/ASA Guideline Source Type: research

Causes of ischemic stroke in young adults versus non-young adults: A multicenter hospital-based observational study
CONCLUSIONS: Certain embolic sources and uncommon causes may be etiologically important causes of ischemic stroke in young adults. However, the contribution of conventional vascular risk factors and lifestyle-related risk factors is not negligible with advancing age, even in young adults.PMID:35830430 | DOI:10.1371/journal.pone.0268481
Source: Atherosclerosis - July 13, 2022 Category: Cardiology Authors: Yuichiro Ohya Ryu Matsuo Noriko Sato Fumi Irie Kuniyuki Nakamura Yoshinobu Wakisaka Tetsuro Ago Masahiro Kamouchi Takanari Kitazono Investigators for Fukuoka Stroke Registry Source Type: research

Antiphospholipid Syndrome of Late Onset: A Difficult Diagnosis of a Recurrent Embolic Stroke
A 77-year-old woman with atrial fibrillation (AF) treated with warfarin had a cortical left middle cerebral artery (MCA) stroke (October 2009, international normalized ratio [INR], 1.6) and a cortical left frontal stroke (October 2011, INR, 1.9). Anticoagulation was adjusted. In October 2011, she had a right frontal stroke (INR, 2.3). Acetylsalicylic acid (ASA) was temporally added to the treatment. In June 2013, she had a left occipital stroke (INR, 2.3). Warfarin was changed to rivaroxaban. In August 2013, she had a right occipital stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - May 12, 2015 Category: Neurology Authors: Montserrat G. Delgado, Sergio Rodríguez, Raquel García, Pablo Sánchez, Antonio Sáiz, Sergio Calleja Tags: Case Report Source Type: research

First Ischemic Stroke in Sickle-Cell Disease: Are There Any Adult Specificities? Brief Reports
Conclusions— First-ever IS occurring in adults with SCD has specificities that justify further studies conducted in adults with SCD to improve understanding and management.
Source: Stroke - July 27, 2015 Category: Neurology Authors: Calvet, D., Bernaudin, F., Gueguen, A., Hosseini, H., Habibi, A., Galacteros, F., Bartolucci, P. Tags: Acute Cerebral Infarction Brief Reports Source Type: research

Arterial ischemic stroke in HIV: Defining and classifying etiology for research studies
HIV infection, and potentially its treatment, increases the risk of an arterial ischemic stroke. Multiple etiologies and lack of clear case definitions inhibit progress in this field. Several etiologies, many treatable, are relevant to HIV-related stroke. To fully understand the mechanisms and the terminology used, a robust classification algorithm to help ascribe the various etiologies is needed. This consensus paper considers the strengths and limitations of current case definitions in the context of HIV infection. The case definitions for the major etiologies in HIV-related strokes were refined (e.g., varicella zoster v...
Source: Neurology Neuroimmunology and Neuroinflammation - June 29, 2016 Category: Neurology Authors: Benjamin, L. A., Bryer, A., Lucas, S., Stanley, A., Allain, T. J., Joekes, E., Emsley, H., Turnbull, I., Downey, C., Toh, C.-H., Brown, K., Brown, D., Ison, C., Smith, C., Corbett, E. L., Nath, A., Heyderman, R. S., Connor, M. D., Solomon, T. Tags: Viral infections, HIV, All Cerebrovascular disease/Stroke, Vascular dementia, HIV dementia Views [amp ] Reviews Source Type: research

Cerebral Infarction due to Severe ADAMTS-13 Deficiency with Normal Hematological Parameters: A Cause of Cryptogenic Stroke
Stroke is a leading cause of death and disability worldwide, and there are 1.3 million strokes annually in adults less than 50 years old.1 Many of these strokes are cryptogenic, with no clear etiology identified. In this setting clinicians frequently test for rare causes of thrombosis including hyperhomocystinemia, antiphospholipid syndrome, Factor V Leiden, prothrombin gene mutations, and protein C, S or antithrombin deficiency. Thrombotic thrombocytopenic purpura (TTP) causes arterial thrombosis, but is rarely considered in the evaluation of cryptogenic stroke with normal or near-normal hematologic profiles.
Source: Journal of Stroke and Cerebrovascular Diseases - March 16, 2022 Category: Neurology Authors: Andrew Matthews, Jennifer Yui, Elaine Y. Chiang, Allyson M. Pishko, Adam Cuker, Brett L. Cucchiara, Donna George, Farzana Sayani, Michael T. Mullen Tags: Short Communication Source Type: research

Current Practice and Clinical Utility of Thrombophilia Testing in Hospitalized Patients with Acute Ischemic Stroke
Testing for thrombophilic disorders is often performed in patients after a thrombotic event without a clear etiology, as in cryptogenic acute ischemic stroke (AIS). Although some disorders, notably antiphospholipid antibody syndrome, have a known association with increased arterial thrombotic risk,1 the role of other commonly tested thrombophilic disorders in AIS is not well-quantified.2-5 Furthermore, there are few studies to identify interventions, specifically the use of anticoagulation, to decrease recurrent AIS risk.
Source: Journal of Stroke and Cerebrovascular Diseases - August 18, 2020 Category: Neurology Authors: Jori E. May, Kimberly D. Martin, Laura J. Taylor, Radhika Gangaraju, Chen Lin Source Type: research

Failure of Anticoagulation to Prevent Stroke in Context of Lupus-Associated Anti-Phospholipid Syndrome and Mild COVID-19
We present a 43-year-old female with a history of seropositive-antiphospholipid syndrome and systemic lupus erythematosus who developed an acute ischemic stroke in the setting of mild COVID-19 infection despite adherence to chronic systemic anticoagulation.
Source: Journal of Stroke and Cerebrovascular Diseases - April 12, 2021 Category: Neurology Authors: Keith J. Kincaid, Alexis N. Simpkins Source Type: research

Etiology and Treatment of Arterial Ischemic Stroke in Children and Young Adults
Opinion statement Stroke is the second leading cause of death worldwide (Go et al. Circulation 129:e28–292, 2014) and is a major cause of morbidity and mortality. Compared with older adults, arterial ischemic stroke (AIS) is relatively uncommon in children and young adults, comprising 5-10 % of all stroke (Biller Nat Rev Cardiol 6:395–97, 2009), but is associated with significant cost. In contrast to the declining overall incidence of stroke, some early studies suggest that the rate of stroke hospitalizations in children and young adults is rising (George et al. Ann Neurol 70:713–21, 2011; Kissela et al. S...
Source: Current Treatment Options in Neurology - September 18, 2014 Category: Neurology Source Type: research

Stroke and Novel Coronavirus Infection in Humans: A Systematic Review and Meta-Analysis
Conclusions: The occurrence of stroke in patients with COVID-19 infection is uncommon, but it may pose as an important prognostic marker and indicator of severity of infection, by causing large vessels occlusion and exhibiting a thrombo-inflammatory vascular picture. Physicians should be made aware and remain vigilant on the possible two-way relationship between stroke and COVID-19 infection. The rate of stroke among patients with COVID-19 infection may increase in the future as they share the common risk factors.
Source: Frontiers in Neurology - October 5, 2020 Category: Neurology Source Type: research

Long-Term Anticoagulation in Secondary Ischemic Stroke Prevention: The Prospective Multicenter RESTAIC Registry
Conclusion: Long-term OAC in secondary stroke prevention is associated with a lower frequency of bleeding complications than stroke recurrences. No differences between anticoagulant drugs were found in any of the analyzed outcomes. The main cause for OAC switch during follow-up was stroke recurrence.
Source: Frontiers in Neurology - October 19, 2020 Category: Neurology Source Type: research