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Medically Attended Acute Adverse Events in Pregnant People After Coronavirus Disease 2019 (COVID-19) Booster Vaccination
Obstet Gynecol. 2023 May 11. doi: 10.1097/AOG.0000000000005241. Online ahead of print.ABSTRACTIn this multisite, observational, matched cohort study of more than 80,000 pregnant people, receipt of an mRNA monovalent coronavirus disease 2019 (COVID-19) booster vaccination in pregnancy was not associated with increased risk for thrombocytopenia, myocarditis, venous thromboembolism, ischemic stroke, or other serious adverse events within 21 or 42 days after booster vaccination. The mRNA monovalent COVID-19 booster in pregnancy was associated with an increased risk for medically attended malaise or fatigue within 7 days of vac...
Source: Obstetrics and Gynecology - May 11, 2023 Category: OBGYN Authors: Malini B DeSilva Jacob Haapala Gabriela Vazquez-Benitez Thomas G Boyce Candace C Fuller Matthew F Daley Darios Getahun Simon J Hambidge Heather S Lipkind Allison L Naleway Jennifer C Nelson Kimberly K Vesco Eric S Weintraub Joshua T B Williams Ousseny Zer Source Type: research

Stroke in Pregnancy
This article will review current information about the epidemiology, risk factors, pathophysiology, management, and outcomes of conditions associated with maternal stroke.Recent FindingsPregnancy confers a substantially increased risk of stroke in women. The period of highest risk of stroke is the peripartum and 6-week post-partum period, coinciding with the highest risk for hypertensive disorders of pregnancy and peak gestational hypercoagulability. Physiological changes of pregnancy, including hypercoagulable states, venous stasis, and hemodynamic changes, are significant contributors to maternal stroke. However, hyperte...
Source: Current Obstetrics and Gynecology Reports - February 22, 2023 Category: OBGYN Source Type: research

Preoperative anemia and complications after surgery for pelvic organ prolapse: an analysis of the national surgical quality improvement program database
ConclusionsPreoperative anemia is associated with an increased risk of adverse postoperative outcomes in women having surgery for pelvic organ prolapse.
Source: International Urogynecology Journal - April 24, 2021 Category: OBGYN Source Type: research

Stroke in Pregnancy
Pregnancy confers a substantially increased risk of stroke, especially during the third trimester and until 6  weeks postpartum. Hypertensive disorders of pregnancy and gestational hypercoagulability are important contributors to obstetric stroke. Preeclampsia and eclampsia confer risk for future cardiovascular disease. Hemorrhagic stroke is the most common type of obstetric stroke. Ischemic stroke can res ult from cardiomyopathy, paradoxical embolism, posterior reversible encephalopathy, reversible cerebral vasoconstriction syndrome, and dissections. Cerebral venous sinus thrombosis is a frequent complication of pregnancy.
Source: Obstetrics and Gynecology Clinics - February 9, 2021 Category: OBGYN Authors: Erica C. Camargo, Aneesh B. Singhal Source Type: research

Coronavirus disease 2019 in pregnancy: consider thromboembolic disorders and thromboprophylaxis
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory distress syndrome coronavirus 2. This syndrome generally begins with respiratory symptoms that may progress to single-organ dysfunction (ie, respiratory failure) and then to multiorgan failure and death. In nonpregnant patients admitted to the intensive care unit with COVID-19 pneumonia, the frequency of venous thromboembolic disorders is 25% (20 of 81) detected by ultrasound examination of the lower extremities.1 In another series of 184 patients with confirmed COVID-19 pneumonia, 31% of patients had venous or arterial thromboembolism (defined as ac...
Source: American Journal of Obstetrics and Gynecology - April 21, 2020 Category: OBGYN Authors: Gian Carlo Di Renzo, Irene Giardina Tags: Letter to the Editors Source Type: research

Women's Health Initiative clinical trials: potential interactive effect of calcium and vitamin D supplementation with hormonal therapy on cardiovascular disease
Conclusions: CaD did not consistently modify the effect of CEE therapy or CEE + MPA therapy on CVD events. However, the increased risk of stroke due to CEE therapy appears to be mitigated by CaD supplementation. In contrast, CaD supplementation did not influence the risk of stroke due to CEE + MPA.
Source: Menopause - August 1, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Multicenter, phase III trials on the contraceptive efficacy, tolerability and safety of a new drospirenone only pill
ConclusionsThis is the first report of a new drospirenone only oral contraceptive providing clinical efficacy like combined oral contraceptives, with a good safety profile, and favourable cycle control.This article is protected by copyright. All rights reserved.
Source: Acta Obstetricia et Gynecologica Scandinavica - July 17, 2019 Category: OBGYN Authors: Santiago Palacios, Enrico Colli, Pedro ‐Antonio Regidor Tags: Original Research Article Source Type: research

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