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E-105 Analysis of clinical associations of serum SCFAs taken at the time of thrombectomy in AIS patients
ConclusionsThe evaluation of SCFAs in the serum at the time of stroke provides novel insight into the potential role of SCFAs during stroke in human patients. Age remains a significant factor to SCFA concentrations in stroke patients. The length of time following stroke also contributes to the levels of SCFAs. Previous studies have shown that increased levels of SCFAs is associated with decreased severity of stroke, however our data did not detect any such effect. This observation may be due to the acute time of the blood collection following stroke and analyzing serum instead of fecal samples. Furthermore, acquiring infor...
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Henry, N., Frank, J., Fraser, J., Trout, A., Morris, A., Chen, J., Stowe, A., McLouth, C., Pennypacker, K. Tags: Electronic poster abstracts Source Type: research

E-127 Combined MIVI-Q™ aspiration catheter-Stent retriever approach to stroke thrombectomy: Preliminary clinical experience
ConclusionsThis preliminary study found good efficacy and safety for MIVI Q™ aspiration catheters used in combination with stent-retriever devices.TableShows main Angiographic, Clinical efficacy and safety outcomes.Abstract E-127 Table 1Angiographic outcomes and clinical efficacyGroin-puncture-to-revascularization [min], median (IQR) 42 (22-66) QTM tFPE, n (%) 22 (42.3) QTM FPE, n (%) 25 (48) mTICI 3, n (%) 28 (53.8) mTICI 2c-3, n (%) 35 (67.3) mTICI ≥ 2b, n (%) 47 (90.4) mRS 0-2 at 90 days, n (%) 24 (46.2) sICH, n (%) 1 (1.9) Serious device-related adverse events, n (%) 0 (0) Serious procedure related adverse ev...
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Remollo, S. Tags: Electronic poster abstracts Source Type: research

P-042 Initial experience with tenecteplase as the intravenous thrombolytic of choice before mechanical thrombectomy for large vessel occlusion acute ischemic stroke
ConclusionIntravenous TNK in patients with LVOAIS is feasible, safe and effective. In our cohort from ‘real world’ patients, TNK was associated with lower need for MT, high recanalization rates and shorter hospitalization.Disclosures U. Ugur: None. S. Platko: None. D. Peters: None. F. Bensabeur: None. J. Terry: None. B. Ludwig: None. E. Cheng-Ching: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Ugur, U., Platko, S., Peters, D., Bensabeur, F., Terry, J., Ludwig, B., Cheng-Ching, E. Tags: Oral poster abstracts Source Type: research

P-052 A novel ex-vivo model to simulate delayed aneurysm rupture after flow-diverter treatment
ConclusionFurther analysis of the tissue samples is underway, in an attempt to quantify the MMP concentration and its correlation to reduced modulus. This study will hopefully lead to the identification of an MMP dose and digestion regimen that can create a reliable benchtop DAR model. A benchtop DAR model would allow for the assessment of new aneurysm treatment options, and the development of new treatment devices for reducing DAR in patients with GIAs.Disclosures H. Sodawalla: None. W. Merritt: None. G. Uyeda: 1; C; ¡MIRA! Exploratory Research AY 2020-21. T. Becker: 1; C; ¡MIRA! Exploratory Research AY 2020-21.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Sodawalla, H., Merritt, W., Uyeda, G., Becker, T. Tags: Oral poster abstracts Source Type: research

E-004 Focal intracranial vasculopathy as a manifestation of COVID-19-associated acute ischemic stroke
ConclusionTo our knowledge, our case is the first to illustrate the potential for COVID-19 infection to present as a focal intracranial vasculopathy in an otherwise healthy young-patient, resulting in acute ischemic stroke without an underlying hypercoagulable state. Rescue intracranial stenting was necessary to maintain vessel patency and restore intracranial flow.Disclosures A. Mahapatra: None. A. Witek: None. G. Toth: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Mahapatra, A., Witek, A., Toth, G. Tags: Electronic poster abstracts Source Type: research

E-005 Preliminary results of the SUMMIT NZ ischemic stroke trial: MonoPoint(R) embolectomy featuring a novel 088 aspiration catheter and specialized delivery catheter
ConclusionsPreliminary findings suggest that first-line aspiration embolectomy using a novel MonoPoint® system including an 0.088" inner diameter aspiration catheter achieves a high rate of arterial revascularization with an acceptable safety profile. A full report on enrollment and results are to be presented.Disclosures S. Brew: 1; C; Route 92 Medical. 2; C; Route 92 Medical, Microvention. B. McGuinness: 1; C; Route 92 Medical. 2; C; Route 92 Medical. J. Caldwell: 1; C; Route 92 Medical. 2; C; Route 92 Medical. S. Lee: 1; C; Route 92 Medical. P. Barber: None. A. Holden: 2; C; Medtronic, Gore, Boston Scientific. T. Wu...
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Brew, S., McGuinness, B., Caldwell, J., Lee, S., Barber, P., Holden, A., Wu, T., Krauss, M., Laing, A., Collecutt, W., Liebeskind, D., Hetts, S. Tags: Electronic poster abstracts Source Type: research

E-034 EndoVascular treatment of wide-neck aneurysms, an evaluation of safety and effectiveness of stryker surpass evolve™ flow diverter system
ConclusionThe EVOLVE prospective, multicenter, single arm, pre-market study (ClinicalTrials.gov NCT: NCT04195568), is designed to evaluate the safety, efficacy, and performance of the Surpass EVOLVE Flow Diverter System in the treatment of unruptured wide-neck, saccular or fusiform IA located in the ICA and its branches with an RVD of 2.5 to 5.0 mm.Disclosures A. Arthur: 2; C; Stryker Neurovascular. J. Fifi: 1; C; Stryker Neurovascular. 2; C; Stryker Neurovascular. H. Rice: 2; C; Stryker Neurovascular. A. Wakhloo: 2; C; Stryker Neurovascular. A. Coon: 2; C; Stryker Neurovascular. V. Pereira: 2; C; Stryker, Medtronic, Balt, Cerenovus.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Arthur, A., Fifi, J., Rice, H., Wakhloo, A., Coon, A., Pereira, V. Tags: Electronic poster abstracts Source Type: research

E-043 Assessing safety of femoral arterial sheath removal in under 24 hours post-intravascular thrombolysis in stroke patients who undergo mechanical thrombectomy
ConclusionSimilar rates of complications were discovered in both groups of patients, without any significant increase in those whose FAS was removed within 24 hours of tPA administration. Further evaluation should be considered to assess the safety of FAS removal in these patients.Disclosures M. Cohen: None. A. Garg: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Cohen, M., Garg, A. Tags: Electronic poster abstracts Source Type: research

E-045 Early neurological improvement is independent predictor of favorable outcome following thrombectomy for basilar artery occlusion
ConclusionENI is an independent predictor of favorable clinical outcome after BAO thrombectomy. Single pass successful recanalization is associated with higher likelihood of ENI.Disclosures S. Majidi: 1; C; SNIS Foundation. S. Matsoukas: None. R. De Leacy: None. T. Oxley: None. H. Shoirah: None. T. Shigematsu: None. C. Kellner: None. J. Mocco: None. J. Fifi: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Majidi, S., Matsoukas, S., De Leacy, R., Oxley, T., Shoirah, H., Shigematsu, T., Kellner, C., Mocco, J., Fifi, J. Tags: Electronic poster abstracts Source Type: research

E-054 The river trial: A prospective single arm trial of stenting the transverse sigmoid sinuses with the river stent in patients with idiopathic intracranial hypertension resistant to medical therapy
ConclusionsThe results so far have shown safety and probable efficacy. Enrollment and follow-up are ongoing and updated results will be presented at the conference.Disclosures A. Patsalides: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Patsalides, A. Tags: Electronic poster abstracts Source Type: research

E-067 Importance of First Pass Reperfusion in Endovascular Stroke Care - Insights from STAR
ConclusionThis analysis of a large, multi-center stroke database confirms the importance of first pass reperfusion in endovascular stroke care.Disclosures I. Maier: None. M. Psychogios: None. J. Liman: None. S. Al Kasab: None. E. Almallouhi: None. A. Alawieh: None. S. Wolfe: None. K. Fargen: None. A. Arthur: None. N. Goyal: None. T. Dumont: None. P. Kan: None. J. Kin: None. R. De Leacy: None. J. Osbun: None. A. Rai: None. P. Jabbour: None. J. Grossberg: None. M. Park: None. R. Starke: None. R. Crosa: None. A. Spiotta: None. D. Behme: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Maier, I., Psychogios, M., Liman, J., Al Kasab, S., Almallouhi, E., Alawieh, A., Wolfe, S., Fargen, K., Arthur, A., Goyal, N., Dumont, T., Kan, P., Kin, J., De Leacy, R., Osbun, J., Rai, A., Jabbour, P., Grossberg, J., Park, M., Starke, R., Crosa, R., Spi Tags: Electronic poster abstracts Source Type: research

E-073 Clot bank collaborative registry protocol: Novel method for evaluating ischemic thrombus
ConclusionWe have developed a novel tissue banking protocol to preserve microbiota from arterial thrombi retrieved from ischemic stroke patients. While there is no consensus which class of pathogens is implicated in the susceptibility to stroke, multiple studies including our own, have shown bacterial fragments and communities in cerebral thrombi. The specimens captured during standard-of-care thrombectomy allow us to characterize and functionally define the microbiota associated with cerebral thrombi in ischemic stroke patients.Disclosures M. Walker: 2; C; Medtronic. A. Edlund: None. C. Dupont: None. G. Tan: None. C. Kell...
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Walker, M., Edlund, A., Dupont, C., Tan, G., Kelly, C., Levy, S., Federico, E., Levitt, M. Tags: Electronic poster abstracts Source Type: research

E-083 Safety and efficacy of xact stent in tandem internal carotid artery and intracranial large vessel occlusion
ConclusionsThe Xact carotid stent is safe and efficacious in the treatment of tandem ICA/ICAO lesions. Larger prospective trials are needed to help confirm our retrospective findings.Disclosures M. Oliver: None. G. Dawod: None. S. Zaidi: None. M. Jumaa: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Oliver, M., Dawod, G., Zaidi, S., Jumaa, M. Tags: Electronic poster abstracts Source Type: research

E-095 The embotrap stent retriever for treatment of acute ischemic stroke: Impact of hospital procedural volume on real world outcomes
ConclusionsHospital MT volume significantly influenced the rate of readmissions among AIS patients treated with the EmboTrap® (alone or with another MT device) device. The lack of difference in mortality may also be reflective of limited statistical power to detect differences in study groups. Further research to understand the impact of hospital MT volume on patient outcomes, as well as identify the threshold volume that optimizes positive outcomes, could help inform future stroke care guidelines and contribute to improved treatment protocols in low-volume centers.Disclosures S. Ikeme: None. E. Kottenmeier: None. A. K...
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Ikeme, S., Kottenmeier, E., Khaled, A., M, S., Khanna, R. Tags: Electronic poster abstracts Source Type: research

Successful recanalization in acute basilar artery occlusion treated with endovascular therapy is independent of thrombus length
Conclusions Successful recanalization does not depend on thrombus length in patients with BAO treated with EVT. Recanalization can therefore be achieved despite high clot burden. Additionally, a high density of thrombi was a strong predictor of a favorable outcome.
Source: Journal of NeuroInterventional Surgery - October 13, 2017 Category: Neurosurgery Authors: Shu, L., Riedel, C., Meyne, J., Jansen, O., Jensen-Kondering, U. Tags: Ischemic stroke Source Type: research

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