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Plaque Evaluation by Ultrasound and Transcriptomics Reveals BCLAF1 as a Regulator of Smooth Muscle Cell Lipid Transdifferentiation in Atherosclerosis
CONCLUSIONS: Plaque echogenicity correlated with enrichment of distinct molecular pathways and identified BCLAF1, previously not described in atherosclerosis, as the most significant gene. Functionally, BCLAF1 seems necessary for survival and transdifferentiation of SMCs into a macrophage-like phenotype. The role of BCLAF1 in plaque vulnerability should be further evaluated.PMID:35321563 | DOI:10.1161/ATVBAHA.121.317018
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 24, 2022 Category: Cardiology Authors: Urszula Rykaczewska Quanyi Zhao Peter Saliba-Gustafsson Mariette Lengquist Malin Kronqvist Otto Bergman Zhiqiang Huang Kent Lund Katarina Waden Vila Z Pons Kenneth Caidahl Josefin Skogsberg Vladana Vukojevic Jan H N Lindeman Joy Roy G öran K Hansson Ecka Source Type: research

Immediate postoperative interventional therapy for neurologic salvage when cerebral thromboembolism complicates carotid endarterectomy
In this study,we report three patients in our institution who received immediate post-operative interventional therapy for neurological salvage, in the setting of cerebral embolism after CEA.PMID:34957793 | DOI:10.31083/j.rcm2204158
Source: Reviews in Cardiovascular Medicine - December 27, 2021 Category: Cardiology Authors: Chunlei Wang Bingjie Zheng Ilgiz Gareev Ozal Beylerli Yan Gu Shancai Xu Zhiyong Ji Pei Wu Huaizhang Shi Source Type: research

Reply
We would like to thank Lazarides et  al in their letter to the editor regarding our report “Literature Review of Primary versus Patching versus Eversion as Carotid Endarterectomy Closure.”1 We agree with most of their comments. However, we did include a meta-analysis by Texakalidis et al.2 They had performed a meta-analysis of r andomized trials comparing bovine pericardium and other patch materials for carotid endarterectomy (CEA), which showed that the incidence of 30-day stroke, myocardial infarction, wound infection, death, cranial nerve injury, carotid artery thrombosis, and death were comparable.
Source: Journal of Vascular Surgery - September 29, 2021 Category: Surgery Authors: Ali F. AbuRahma, R. Clement Darling Tags: Letter to the Editor Source Type: research

A Systematic Review and Meta-analysis of Peri-Procedural Outcomes in Patients Undergoing Carotid Interventions Following Thrombolysis
CONCLUSION: Peri-procedural ICH and local haematoma were significantly more frequent in patients undergoing CEA after TT (vs. no TT), although there were no randomised comparisons. Peri-procedural hazards were also significantly higher for CAS after TT. The inverse relationship between timing to CEA and peri-procedural stroke/death mandates careful patient selection and suggests that it may be safer to defer CEA for six-seven days after TT.PMID:34266765 | DOI:10.1016/j.ejvs.2021.06.003
Source: PubMed: Eur J Vasc Endovasc ... - July 16, 2021 Category: Surgery Authors: Stavros K Kakkos Melina Vega de Ceniga Ross Naylor Source Type: research

Warfarin Treatment Is Associated to Increased Internal Carotid Artery Calcification
Conclusions: Long-lasting warfarin anticoagulation associated with increased calcification of carotid atherosclerotic plaques, particularly in locations known to be the predilection sites of stroke-causing plaques. The clinical significance of this novel finding warrants further investigations.
Source: Frontiers in Neurology - July 12, 2021 Category: Neurology Source Type: research

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