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Condition: Thrombosis
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Total 8544 results found since Jan 2013.

Effect of the neutral CLOTS 1 trial on the use of graduated compression stockings in the Efficacy of Nitric Oxide Stroke (ENOS) trial
Conclusions GCS use declined dramatically following the reporting of the CLOTS-1 trial. The results support the notion that a neutral trial of a device can influence clinical practice rapidly, which is important with a widely used and moderately expensive (time and finance) intervention.
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 15, 2013 Category: Neurosurgery Authors: Ankolekar, S., Renton, C., Bereczki, D., Sprigg, N., Payne, T., Gommans, J., Berge, E., Wardlaw, J., Dennis, M. S., Bath, P. M. W., for the ENOS Trial Investigators, Amarenco, Bath, Lees, Muir, Pocock, Shone, Sinclair, Venables, Wardlaw, Whynes, Bladin, C Tags: Drugs: CNS (not psychiatric), Stroke Cerebrovascular disease Source Type: research

Toward a better understanding of PFO and stroke risk
A patent foramen ovale (PFO) is a remnant of the fetal circulation and may be found in approximately 25% of adults.1 Multiple case-control studies have demonstrated an association between PFO and cryptogenic ischemic stroke, particularly in younger patients.2 The mechanism for the association is presumed to be venous thromboembolism through the PFO and into the cerebral circulation (i.e., paradoxical embolization).3 Randomized studies of percutaneous PFO closure devices for secondary stroke prevention have been in progress for years with slow enrollment because of off-label use of atrial septal defect closure devices.4,5 T...
Source: Neurology - August 12, 2013 Category: Neurology Authors: Messe, S. R., Kernan, W. N. Tags: Stroke in young adults, Stroke prevention, Prognosis, Embolism EDITORIALS Source Type: research

Incidence of Venous Thromboembolism in the Wake of the Clots in Legs Or sTockings after Stroke (CLOTS) Study Brief Reports
Conclusions— Discontinuation of compressive stockings did not increase venous thromboembolism incidence. There was a trend toward more deep vein thrombosis and fewer PEs after CLOTS, which might be because of increased clinical vigilance in the diagnosis of deep vein thrombosis, but a chance variation cannot be excluded.
Source: Stroke - September 23, 2013 Category: Neurology Authors: Jain, P., Ward, E., Nevatte, T., Roffe, C. Tags: Deep vein thrombosis Brief Reports Source Type: research

Decompressive Hemicraniectomy for Malignant Hemispheric Stroke in the Elderly: Comparison of Outcomes between Individuals 61-70 and >70 Years of Age
Conclusions: We suggest that the efficacy of DHC in malignant hemispheric stroke patients between 61 and 70 years of age be further investigated in future randomized trials. By contrast, it appears unlikely that patients>70 years of age would benefit from DHC.
Source: Journal of Stroke and Cerebrovascular Diseases - March 13, 2013 Category: Neurology Authors: Joji Inamasu, Takafumi Kaito, Takeya Watabe, Tsukasa Ganaha, Yasuhiro Yamada, Teppei Tanaka, Shuei Imizu, Takuro Hayashi, Motoharu Hayakawa, Yoko Kato, Yuichi Hirose Tags: Original Articles Source Type: research

Prehospital factors determining regional variation in thrombolytic therapy in acute ischemic stroke
ConclusionsThese results suggest that the larger proportion of patients arriving within 4·5 h in the centralized model might be related to a lower threshold to use emergency services to transport stroke patients and partly to preferential referral of thrombolysis candidates.
Source: International Journal of Stroke - December 23, 2013 Category: Neurology Authors: Maarten M. H. Lahr, Patrick C. A. J. Vroomen, Gert‐Jan Luijckx, Durk‐Jouke Zee, Ronald Vos, Erik Buskens Tags: Research Source Type: research

Usefulness of N-Terminal Pro-B-Type Natriuretic Peptide Levels for Stroke Risk Prediction in Anticoagulated Patients With Atrial Fibrillation Clinical Sciences
Conclusions— In real-world cohort of anticoagulated patients with AF, NT-proBNP provided complementary prognostic information to an established clinical risk score (CHA2DS2–VASc) for the prediction of stroke/systemic embolism. NT-proBNP was also predictive of all-cause mortality, suggesting that this biomarker may potentially be used to refine clinical risk stratification in anticoagulated patients with AF.
Source: Stroke - February 24, 2014 Category: Neurology Authors: Roldan, V., Vilchez, J. A., Manzano-Fernandez, S., Jover, E., Galvez, J., Puche, C. M., Valdes, M., Vicente, V., Lip, G. Y. H., Marin, F. Tags: Arterial thrombosis, Coumarins, Anticoagulants Clinical Sciences Source Type: research

Combination Treatment With N-Acetyl-Seryl-Aspartyl-Lysyl-Proline and Tissue Plasminogen Activator Provides Potent Neuroprotection in Rats After Stroke Basic Sciences
Conclusions— Our data indicate that AcSDKP passes the blood–brain barrier, and that treatment of acute stroke with AcSDKP either alone at 1 hour or in combination with tPA at 4 hours of the onset of stroke is effective to reduce ischemic cell damage in a rat model of embolic stroke. Inactivation of TGF-β and NF-B signaling by AcSDKP in the neurovascular unit may underlie the neuroprotective effect of AcSDKP.
Source: Stroke - March 24, 2014 Category: Neurology Authors: Zhang, L., Chopp, M., Teng, H., Ding, G., Jiang, Q., Yang, X. P., Rhaleb, N. E., Zhang, Z. G. Tags: Acute Cerebral Infarction Basic Sciences Source Type: research

Thrombolytic therapy for stroke in patients with preexisting cognitive impairment
Conclusions: Ischemic stroke patients with PSCI should receive rtPA if they are eligible. This conclusion cannot be extended to severe cognitive impairment or severe strokes. Classification of evidence: This study provides Class IV evidence that in patients with PSCI presenting with acute ischemic stroke, IV rtPA improves outcomes.
Source: Neurology - June 9, 2014 Category: Neurology Authors: Murao, K., Leys, D., Jacquin, A., Kitazono, T., Bordet, R., Bejot, Y., Kimura, K., Godefroy, O., Wakisaka, Y., Moulin, S., Ago, T., Sibon, I., Bombois, S., Mas, J.-L., Henon, H., Pasquier, F., Giroud, M., Cordonnier, C., Okada, Y., On behalf of the OPHELI Tags: All Cerebrovascular disease/Stroke, All Cognitive Disorders/Dementia, MCI (mild cognitive impairment), Infarction ARTICLE Source Type: research

Earlier thrombolytic treatment is associated with better outcomes following acute ischaemic stroke
Commentary on Saver JL, Fonarow GC, Smith EE, et al.. Time to treatment with intravenous tissue plasminogen activator and outcome from acute ischaemic stroke, JAMA 2013;309:2480–8. Implications for practice and research Optimisation is necessary in public education and hospital triage of the identification of factors such as arrival by ambulance and the importance of requesting emergency medical services (EMS) at scene of the stroke occurrence.1 The results of previous studies suggest that a disparity, observed between hospital-based outcomes for admissions that presented during regular hours and off hours, is not se...
Source: Evidence-Based Nursing - September 15, 2014 Category: Nursing Authors: Ullah, N., Thompson, M. J., Qureshi, A. I. Tags: Adult nursing, Drugs: cardiovascular system, Stroke Source Type: research

Cervical Arterial Dissections and Association With Cervical Manipulative Therapy: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association AHA/ASA Scientific Statement
Conclusions— CD is an important cause of ischemic stroke in young and middle-aged patients. CD is most prevalent in the upper cervical spine and can involve the internal carotid artery or vertebral artery. Although current biomechanical evidence is insufficient to establish the claim that CMT causes CD, clinical reports suggest that mechanical forces play a role in a considerable number of CDs and most population controlled studies have found an association between CMT and VAD stroke in young patients. Although the incidence of CMT-associated CD in patients who have previously received CMT is not well established, an...
Source: Stroke - September 22, 2014 Category: Neurology Authors: Biller, J., Sacco, R. L., Albuquerque, F. C., Demaerschalk, B. M., Fayad, P., Long, P. H., Noorollah, L. D., Panagos, P. D., Schievink, W. I., Schwartz, N. E., Shuaib, A., Thaler, D. E., Tirschwell, D. L., on behalf of the American Heart Association Strok Tags: AHA Statements and Guidelines AHA/ASA Scientific Statement Source Type: research

Thrombus density predicts successful recanalization with Solitaire stent retriever thrombectomy in acute ischemic stroke
Conclusions In acute stroke treated with Solitaire stent retriever thrombectomy, higher thrombus HU values are predictive of successful recanalization. Such information can be used in decision making when estimating recanalization success rate with different endovascular treatment approaches.
Source: Journal of NeuroInterventional Surgery - January 13, 2015 Category: Neurosurgery Authors: Mokin, M., Morr, S., Natarajan, S. K., Lin, N., Snyder, K. V., Hopkins, L. N., Siddiqui, A. H., Levy, E. I. Tags: Ischemic stroke Source Type: research

High levels of von Willebrand factor and low levels of its cleaving protease, ADAMTS13, are associated with stroke in young HIV‐infected patients
ConclusionsStroke in human immunodeficiency virus infection is associated with a prothrombotic state, characterized by elevated von Willebrand factor and low ADAMTS13 levels.
Source: International Journal of Stroke - June 29, 2015 Category: Neurology Authors: Sameera Allie, Alan Stanley, Alan Bryer, Muriel Meiring, Marc I. Combrinck Tags: Research Source Type: research

Alteplase Reduces Downstream Microvascular Thrombosis and Improves the Benefit of Large Artery Recanalization in Stroke Basic Sciences
Conclusions— Our data demonstrate that DMT is an early phenomenon initiated before recanalization. We further show that alteplase-dependent maintenance of downstream perfusion during MCAO improves acute ischemic stroke outcome through a fibrinogen-dependent platelet aggregation reduction. Our results indicate that early targeting of DMT represents a therapeutic strategy to improve the benefit of large artery recanalization in acute ischemic stroke.
Source: Stroke - October 26, 2015 Category: Neurology Authors: Desilles, J.-P., Loyau, S., Syvannarath, V., Gonzalez-Valcarcel, J., Cantier, M., Louedec, L., Lapergue, B., Amarenco, P., Ajzenberg, N., Jandrot-Perrus, M., Michel, J.-B., Ho-Tin-Noe, B., Mazighi, M. Tags: Fibrinolysis, Fibrinogen/fibrin, Acute Cerebral Infarction, Brain Circulation and Metabolism, Thrombolysis Basic Sciences Source Type: research

Multicenter clinical experience in over 125 patients with the Penumbra Separator 3D for mechanical thrombectomy in acute ischemic stroke
Conclusions The results suggest that the Separator 3D enables safe and effective revascularization of occluded large arteries in acute stroke intervention, leading to a high rate of functional independence at 90 days.
Source: Journal of NeuroInterventional Surgery - December 13, 2015 Category: Neurosurgery Authors: Behme, D., Kowoll, A., Mpotsaris, A., Hader, C., Hechelhammer, L., Weber, J., Weber, W. Tags: Ischemic stroke Source Type: research

90 Day Outcome after Reperfusion Therapy of Stroke Patients with Baseline Disability: Unique Observations from Patients Treated on the Mobile Stroke Unit (P6.052)
Conclusion: In comparison to previously published data our analysis shows unfavorable outcome in the majority of patients with baseline disability who received thrombolytic therapy. The small sample size is a limitation to this analysis, and further studies are needed to assess if this subpopulation should be included in clinical trials assessing new therapies or modalities to deliver them.Disclosure: Dr. almaghrabi has nothing to disclose. Dr. Sarraj has nothing to disclose. Dr. Bowry has nothing to disclose. Dr. Parker has nothing to disclose. Dr. Yamal has nothing to disclose. Dr. Grotta has received personal compensati...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Almaghrabi, T., Sarraj, A., Bowry, R., Parker, S., Yamal, J.-M., Grotta, J. Tags: Prehospital Stroke Care and Uses of NIHSS Source Type: research