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Condition: Thrombosis
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Total 8544 results found since Jan 2013.
Predictors of Left Atrial Thrombi and Spontaneous Echocardiographic Contrast in the Acute Phase After Cardioembolic Stroke in Patients With Atrial Fibrillation
This study aims to investigate the utility of CHADS2 and CHA2DS2-VASc scores for predicting LAT/SEC, and to investigate the risk factors of residual LAT/SEC after CES onset. Methods: This retrospective study included 124 patients who were admitted with the acute phase of CES at our center. The clinical, echocardiographic variables, the CHADS2/CHA2DS2-VASc scores, and National Institutes of Health Stroke Scale score were retrospectively assessed on admission.
Source: Journal of Stroke and Cerebrovascular Diseases - March 28, 2019 Category: Neurology Authors: Hideyuki Kishima, Takanao Mine, Eiji Fukuhara, Kenki Ashida, Kazutaka Uchida, Shinichi Yoshimura, Masaharu Ishihara Source Type: research
The Value of the CHADS2 and CHA2DS2-VASc Score for Predicting the Prognosis in Lacunar Stroke with or without Atrial Fibrillation Patients
Background: The CHADS2 and CHA2DS2-VASc scoring systems have been proved efficacy to stratify stroke and thromboembolism risk in patients with atrial fibrillation (AF). Whether CHADS2 and CHA2DS2-VASc score has predictive value for the prognosis in lacunar stroke (LS) patients remains unclear. Methods: A total of 763 consecutive patients with LS (mean age: 66 ± 12 years; 464 male) were enrolled in this study between January 2013 and December 2014. Patients were divided into LS without AF (LS; n = 679) and LS with AF (LS-AF; n = 84) groups.
Source: Journal of Stroke and Cerebrovascular Diseases - August 29, 2019 Category: Neurology Authors: Hong-Jie Yang, Guang-Ji Wang, Wei Shuai, Cai-Jie Shen, Bin Kong, He Huang Source Type: research
The First 10 Thrombolysis for Acute Ischemic Stroke in Lao People's Democratic Republic under Teleconsultation from Thailand
This study aimed to evaluate the feasibility and safety of thrombolytic therapy administration at Mittaphab Hospital, Lao PDR under the international telestroke consultation system from King Chulalongkorn Memorial Hospital, Thailand. Methods: Acute ischemic stroke patients who presented at Mittaphab Hospital within 4.5 hours after the onset and received thrombolytic therapy between December 2016 and June 2017 were studied.
Source: Journal of Stroke and Cerebrovascular Diseases - September 13, 2019 Category: Neurology Authors: Aurauma Chutinet, Saysavath Keosodsay, Pongpat Vorasayan, Jitlada Samajarn, Wasan Akarathanawat, Naruchorn Kijpaisalratana, Naly Norsakpeseuth, Ketmany Phetsiriseng, Snong Thongsna, Pakkawan Vongvasinkul, Nijasri C. Suwanwela Source Type: research
Multicenter prospective analysis of stroke patients taking oral anticoagulants: The PASTA registry - Study design and characteristics
The management of atrial fibrillation and deep venous thrombosis has evolved with the development of direct oral anticoagulants (DOAC), and oral anticoagulant (OAC) might influence the development or clinical course in both ischemic and hemorrhagic stroke. However, detailed data on the differences between the effects of the prior prescription of warfarin and DOAC on the clinical characteristics, neuroradiologic findings, and outcome of stroke are limited.
Source: Journal of Stroke and Cerebrovascular Diseases - October 28, 2019 Category: Neurology Authors: Satoshi Suda, Yasuyuki Iguchi, Shigeru Fujimoto, Yoshiki Yagita, Yu Kono, Masayuki Ueda, Kenichi Todo, Tomoyuki Kono, Takayuki Mizunari, Mineo Yamazaki, Takao Kanzawa, Seiji Okubo, Kimito Kondo, Nobuhito Nakajima, Takeshi Inoue, Takeshi Iwanaga, Makoto Na Source Type: research
Efficacy and Safety of Thrombolytic Therapy for Stroke with Unknown Time of Onset: A Meta-Analysis of Observational Studies
Recombinant tissue plasminogen activator (rt-PA) is one of the most effective therapies available for patients with known-onset stroke (KOS). Whether rt-PA treatment would improve functional outcomes in patients with stroke with unknown time of onset (UTOS) is undetermined, we aimed to systematically assess the efficacy and safety of thrombolysis for UTOS patients in this meta-analysis.
Source: Journal of Stroke and Cerebrovascular Diseases - February 28, 2020 Category: Neurology Authors: Ruo-lin Zhu, Jing Xu, Cheng-juan Xie, Ying Hu, Kai Wang Source Type: research
Low Serum Eicosapentaenoic Acid Levels in Cryptogenic Stroke with Active Cancer
Since Armand Trousseau first described migratory superficial thrombophlebitis in 1865, patients with malignant cancer have been known to be in a hypercoagulable state and at risk for the development of cancer-associated thrombosis.1 Approximately 7% of cancer patients have symptomatic cerebrovascular diseases during the clinical course of cancer, and 15% have cerebrovascular lesions at autopsy.2 Previous studies have demonstrated that cancer patients with cryptogenic ischemic stroke often have high serum D-dimer levels and multiple vascular lesions and show cryptogenic stroke etiology, which seems to be due to a hypercoagulable state.
Source: Journal of Stroke and Cerebrovascular Diseases - May 14, 2020 Category: Neurology Authors: Tesseki Izumi, Hitoki Nanaura, Naohiko Iguchi, Maki Ozaki, Kazuma Sugie Source Type: research
Iodinated Contrast Agents Reduce the Efficacy of Intravenous Recombinant Tissue-Type Plasminogen Activator in Acute Ischemic Stroke Patients: a Multicenter Cohort Study
This study aimed to investigate whether the application of iodinated contrast agents before intravenous (IV) recombinant tissue plasminogen activator (rt-PA) reduces the efficacy in acute ischemic stroke (AIS) patients. To determine whether the application of iodinated contrast agents before intravenous rt-PA reduces the efficacy in AIS patients. We analyzed our prospectively collected data of consecutive AIS patients receiving IV rt-PA treatment in the MISSION CHINA study. Clinical outcome at 3  months was assessed with modified Rankin Scale (mRS) score and dichotomized into good outcome (0–2) and poor outcome (3–6)....
Source: Translational Stroke Research - September 7, 2020 Category: Neurology Source Type: research
Efficacy and Safety of Recombinant Human Prourokinase in Acute Ischemic Stroke: A Phase IIa Randomized Clinical Trial
AbstractRecombinant human prourokinase (rhPro-UK) is a novel thrombolytic that has been approved to treat patients with acute myocardial infarction. However, the safety and efficacy of intravenous rhPro-UK in patients with acute ischemic stroke (AIS) has not been well established. We aimed to investigate the safety and preliminary efficacy of rhPro-UK in patients with AIS in a multi-center phase IIa trial setting. One hundred nineteen patients within 4.5  h of AIS onset were enrolled in this randomized, open-label, 23-center phase IIa clinical trial. Patients were randomly assigned to 35 mg (n = 40) or 50 mg (n =â...
Source: Translational Stroke Research - May 3, 2022 Category: Neurology Source Type: research
Similarities and Differences in Systemic Risk Factors for Retinal Artery Occlusion and Stroke: A Nationwide Case-Control Study
This study compares risk factor profiles for thromboembolism among patients with RAO and stroke, respectively.
Source: Journal of Stroke and Cerebrovascular Diseases - June 28, 2022 Category: Neurology Authors: Marie Ørskov, Henrik Vorum, Torben Bjerregaard Larsen, Gregory Y.H. Lip, Toke Bek, Flemming Skjøth Source Type: research
Recombinant tissue plasminogen activator (rTPA) management for first onset acute Ischemic Stroke with covid -19 and non-covid -19 patients
In this study we compare the efficacy and safety of Tissue plasminogen activator (rTPA) in acute ischemic stroke (AIS) patients with or without Covid-19 infection.
Source: Journal of Stroke and Cerebrovascular Diseases - January 22, 2023 Category: Neurology Authors: Eman M Khedr, Ahmed Abdelwarith, Gehad M Moussa, Mostafa Saber Source Type: research
Thrombus imaging characteristics within acute ischemic stroke: similarities and interdependence
Conclusions
Thrombus imaging characteristics are significantly intercorrelated – strong correlations should be considered in future predictive modeling studies. Clustering analysis showed there are no distinct thrombus archetypes – novel treatments should consider this thrombus variability.
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Arrarte Terreros, N., Bruggeman, A. A., Kappelhof, M., Tolhuisen, M. L., Brouwer, J., Hoving, J. W., Konduri, P. R., van Kranendonk, K. R., Dutra, B. G., Alves, H. C., Dippel, D. W., van Zwam, W. H., Beenen, L. F., Yo, L. S., van Bavel, E., Majoie, C. B., Tags: Open access, Ischemic stroke Source Type: research
Role of Balloon-Expandable Stents in Intracranial Atherosclerotic Disease in a Series of 182 Patients Brief Reports
Conclusions—
Treatment of intracranial atherosclerotic disease with balloon-expandable intracranial stents is a safe and effective method with acceptable adverse events, especially in patients who failed medical therapy and were symptomatic despite being on optimum medical therapy.
Source: Stroke - June 24, 2013 Category: Neurology Authors: Alurkar, A., Karanam, L. S. P., Oak, S., Nayak, S., Sorte, S. Tags: Angiography, Angioplasty and Stenting, Other Stroke Brief Reports Source Type: research
Efficacy and Safety of a Modified Intravenous Recombinant Tissue Plasminogen Activator Regimen in Chinese Patients with Acute Ischemic Stroke
This study was designed to verify the safety and efficacy of IV rtPA treatment for AIS with a lower dosage (0.90 mg/kg, with a maximum dose of 50 mg). Patients were divided into 3 dosage groups according to body weight (BW): group 1, 67 kg for
Source: Journal of Stroke and Cerebrovascular Diseases - October 29, 2012 Category: Neurology Authors: Shu-Ming Pan, Jia-Fu Liu, Ming Liu, Sa Shen, Hao-Jun Li, Li-Hua Dai, Xiang-Jun Chen Tags: Original Articles Source Type: research
Fragmental or Massive Embolization in Cardiogenic Stroke Caused by Nonvalvular Atrial Fibrillation
Background: After cardioembolic stroke (CES), left atrial thrombus (LAT) is detected by transesophageal echocardiography (TEE) in some cases but not in others. We propose that there are 2 types of embolization in CES: fragmental and massive embolization.Methods: Consecutive patients with nonvalvular atrial fibrillation (AF) of acute CES or transient ischemic attack (TIA) were prospectively enrolled in the study between May 2009 and July 2011. TEE was performed within 7 days of admission. The patients were classified into 2 groups: those with occlusion of the main trunk (internal carotid artery, M1, and basilar artery; grou...
Source: Journal of Stroke and Cerebrovascular Diseases - October 18, 2012 Category: Neurology Authors: Hirokazu Sadahiro, Akinori Inamura, Hideyuki Ishihara, Ichiro Kunitsugu, Hisaharu Goto, Fumiaki Oka, Satoshi Shirao, Hiroshi Yoneda, Yasuaki Wada, Michiyasu Suzuki Tags: Original Articles Source Type: research
Recurrent Ischemic Stroke in a Patient with the Trousseau Syndrome Treated with Dabigatran
A 70-year-old man with multiple ischemic strokes was diagnosed with cardiac embolism and treated with dabigatran. Three months later, he suddenly developed vertigo and vomiting. Magnetic resonance imaging, showed recurrent lesions and blood tests revealed hypercoagulability, hypoproteinemia, and elevated cytokeratin 19 fragments that serve as a tumor marker of lung cancer. Chest computed tomography showed there were small nodules in bilateral lungs and swollen mediastinal lymph nodes. A conclusive diagnosis was impossible because the patient declined invasive procedures. We suspected primary lung cancer and diagnosed conco...
Source: Journal of Stroke and Cerebrovascular Diseases - February 21, 2014 Category: Neurology Authors: Kosuke Yoshida, Takashi Kimura, Yoko Aburakawa, Yasuhiro Suzuki, Kenji Kuroda, Osamu Yahara Tags: Case Reports Source Type: research
