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Discovery of anti-stroke active substances in Guhong injection based on multi-phenotypic screening of zebrafish
Biomed Pharmacother. 2022 Sep 23;155:113744. doi: 10.1016/j.biopha.2022.113744. Online ahead of print.ABSTRACTIschemic stroke is a leading cause of death worldwide, and it remains an urgent task to develop novel and alternative therapeutic strategies for the disease. We previously reported the positive effects of Guhong injection (GHI), composed of safflower extract and aceglutamide, in promoting functional recovery in ischemic stroke mice. However, the active substances and pharmacological mechanism of GHI is still elusive. Aiming to identify the active anti-stroke components in GHI, here we conducted a multi-phenotypic s...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 26, 2022 Category: Drugs & Pharmacology Authors: Yule Wang Huimin Wu Hongda Sheng Yingchao Wang Xuecai Li Yi Wang Lu Zhao Source Type: research

Dietary Meat, Trimethylamine N-Oxide-Related Metabolites, and Incident Cardiovascular Disease Among Older Adults: The Cardiovascular Health Study
CONCLUSIONS: In this large, community-based cohort, higher meat intake associated with incident ASCVD, partly mediated by microbiota-derived metabolites of L-carnitine, abundant in red meat. These novel findings support biochemical links between dietary meat, gut microbiome pathways, and ASCVD.PMID:35912635 | DOI:10.1161/ATVBAHA.121.316533
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 1, 2022 Category: Cardiology Authors: Meng Wang Zeneng Wang Yujin Lee Heidi T M Lai Marcia C de Oliveira Otto Rozenn N Lemaitre Amanda Fretts Nona Sotoodehnia Matthew Budoff Joseph A DiDonato Barbara McKnight W H Wilson Tang Bruce M Psaty David S Siscovick Stanley L Hazen Dariush Mozaffarian Source Type: research

Po-674-04 anticoagulation management and risk of thromboembolism in healthy youth with atrial fibrillation: data from a multi-institutional paces collaborative registry
Stroke is a well-defined complication of atrial fibrillation (AF) in adults. However, the risk of thromboembolism and need for anticoagulation therapy in children and young adults with AF are unknown.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Iqbal El Assaad, Benjamin Hammond, Christopher M. Janson, Elizabeth D. Sherwin, Elizabeth A. Stephenson, Christopher L. Johnsrude, Mary C. Niu, Ira Shetty, David K. Lawrence, Anthony C. McCanta, Seshadri Balaji, Shubhayan Sanatani, Frank A. Fish, Gregory Source Type: research

Many take anticoagulants and OTC supplements, which poses risk
FINDINGSNearly 98% percent of people prescribed direct-acting oral anticoagulants such as apixaban also used  over-the-counter products. Of those, 33% took at least one such product that, in combination with the anticoagulants, could cause dangerous internal bleeding. People taking these medications largely lacked knowledge of some potentially serious interactions.BACKGROUNDDirect-acting oral anticoagulants are the drug of choice for stroke prevention in patients with atrial fibrillation, which occurs most frequently in older patients. Apixaban is one of the most frequently prescribed. However, most people prescribed apix...
Source: UCLA Newsroom: Health Sciences - October 31, 2019 Category: Universities & Medical Training Source Type: news

Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort
Conclusions: Our study suggested that incident CHD was positively associated with plasma levels of titanium and arsenic, and inversely associated with selenium. Additional research is needed to confirm these findings in other populations. https://doi.org/10.1289/EHP1521 Received: 22 December 2016 Revised: 17 September 2017 Accepted: 19 September 2017 Published: 19 October 2017 Address correspondence to T. Wu, or A. Pan, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hongkong Rd., Wuhan 430030, Hubei, China. Telephone: +86-27-83692347. Email: wut@mails.tjmu.edu.cn or p...
Source: EHP Research - October 20, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Diet, microparticles and atherothrombosis.
Abstract Cardiovascular disease is the main cause of death worldwide, and is principally caused by atherosclerosis, with subsequent thrombus formation, eventually provoking an acute myocardial infarction or a stroke. The formation and progression of the atherosclerotic plaques responds to multiple factors including certain diets. Intensive research has elucidated the role of diet in cardiovascular disease and has led to public health policies focusing on educating the population on the role of nutrition in cardiovascular health. Compelling evidence shows that a healthy diet, rich in fruit and vegetables with moder...
Source: Atherosclerosis - September 22, 2017 Category: Cardiology Authors: Badimon L, Suades R, Crespo J, Padro T, Chiva-Blanch G Tags: Front Biosci (Landmark Ed) Source Type: research