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IJERPH, Vol. 17, Pages 618: Risk Factors Associated with Outcomes of Recombinant Tissue Plasminogen Activator Therapy in Patients with Acute Ischemic Stroke
eng Tsong-Hai Lee Ischemic stroke is the most common type of stroke, and early interventional treatment is associated with favorable outcomes. In the guidelines, thrombolytic therapy using recombinant tissue-type plasminogen activator (rt-PA) is recommended for eligible patients with acute ischemic stroke. However, the risk of hemorrhagic complications limits the use of rt-PA, and the risk factors for poor treatment outcomes need to be identified. To identify the risk factors associated with in-hospital poor outcomes in patients treated with rt-PA, we analyzed the electronic medical records of patients who were diagn...
Source: International Journal of Environmental Research and Public Health - January 17, 2020 Category: Environmental Health Authors: Yi-Ju Tseng Ru-Fang Hu Shin-Tyng Lee Yu-Li Lin Chien-Lung Hsu Shih-Wei Lin Chia-Wei Liou Jiann-Der Lee Tsung-I Peng Tsong-Hai Lee Tags: Article Source Type: research

Thromboinflammatory Functions of Platelets in Ischemia –Reperfusion Injury and Its Dysregulation in Diabetes
Semin Thromb Hemost DOI: 10.1055/s-0037-1613694Ischemia–reperfusion (IR) injury is a common complication of a variety of cardiovascular diseases, including ischemic stroke and myocardial infarction (MI). While timely re-establishment of blood flow in a thrombosed artery is the primary goal of acute therapy in these diseases, paradoxically, reperfusion of ischemic tissue can cause widespread microvascular dysfunction that significantly exacerbates organ damage. Reperfusion injury is associated with activation of the humoral and cellular components of the hemostatic and innate immune systems and also with excessive reactiv...
Source: Seminars in Thrombosis and Hemostasis - January 2, 2018 Category: Hematology Authors: Maiocchi, Sophie Alwis, Imala Wu, Mike Chia Lun Yuan, Yuping Jackson, Shaun P. Tags: Review Article Source Type: research

Sickle Mice Are Sensitive to Hypoxia/Ischemia-Induced Stroke but Respond to Tissue-Type Plasminogen Activator Treatment Basic Sciences
Conclusions—Sickle mice are sensitive to hypoxia/ischemia-induced cerebral infarct but benefit from thrombolytic treatment. An increased resistive index in carotid arteries may be an early marker of sickle cell vasculopathy.
Source: Stroke - November 27, 2017 Category: Neurology Authors: Yu-Yo Sun, Jolly Lee, Henry Huang, Mary B. Wagner, Clinton H. Joiner, David R. Archer, Chia-Yi Kuan Tags: Animal Models of Human Disease, Basic Science Research Original Contributions Source Type: research

Obstructive sleep apnea and the risk of ischemic stroke in patients with atrial fibrillation
Atrial fibrillation (AF) is associated with significant morbidity and mortality. Prevention of thromboembolism with oral anticoagulant agents is an important treatment for patients with AF. CHADS2 and CHA2DS2-VASc score has been widely used as the initial approach to assess future stroke risk among AF patients. Obstructive sleep apnea (OSA) is a common breathing disorder associated with substantial cardiovascular morbidity and mortality. It has been reported as an independent risk factor for ischemic stroke [1–4].
Source: International Journal of Cardiology - December 2, 2014 Category: Cardiology Authors: Chun-Chin Chang, Chun-Chih Chiu, Chia-Hung Chiang, Chin-Chou Huang, Wan-Leong Chan, Po-Hsun Huang, Yu-Chun Chen, Tzeng-Ji Chen, Chia-Min Chung, Shing-Jong Lin, Jaw-Wen Chen, Hsin-Bang Leu Tags: Letter to the Editor Source Type: research

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