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Clinical and radiological characteristics and predictors of outcome of cerebral venous sinus thrombosis, a hospital-based study
AbstractCerebral venous sinus thrombosis is an uncommon cause of stroke, which is more prevalent in Iran and the Middle East. We aimed to assess the etiology, radiologic, and clinical manifestations of cerebral venous sinus thrombosis, specifically the predictors of patients ’ outcome in Namazi hospital, Shiraz, Iran. In this retrospective study, we included all adult patients with the diagnosis of cerebral venous sinus thrombosis, who were admitted in hospital, from 2012 to 2016. Demographic data, radiologic findings, clinical presentation, risk factors, treatment, a nd outcome according to modified Rankin Scale (mRS) o...
Source: Acta Neurologica Belgica - September 3, 2018 Category: Neurology Source Type: research

Mechanical Thrombectomy with Solitaire Stent Retrieval for Acute Cardioembolic Stroke.
Conclusion: Some cases of cardioembolic stroke are resistant to MTSR and may need other treatment modalities. Careful interpretation of angiogram may be helpful to the decision. PMID: 29142621 [PubMed]
Source: Journal of Korean Neurosurgical Society - November 18, 2017 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Evaluation of functional outcome measured by modified Rankin scale in rtPA treated patients with acute ischemic stroke.
Authors: Georgievski-Brkic B, Savic M, Nikolic D, Nikcevic L, Vukicevic M, Kozic D Abstract Aim of our study was to assess functional outcome measured by modified Rankin scale (mRS) in patients that were treated with thrombolytic therapy-recombinant tissue plasminogen activator (rtPA) after acute ischemic stroke. The study included 100 participants that were treated after acute ischemic stroke. Analyzed parameters included: gender; age groups: age 54 and below (Groupup to-54), 55-64 (Group55-64), 65-74 (Group65-74), and 75 and above (Group75-up); cerebral blood flow (CBF) and cerebral blood volume (CBV). Considerin...
Source: Archives Italiennes de Biologie - March 23, 2017 Category: Neuroscience Tags: Arch Ital Biol Source Type: research

Impact and Effectiveness of Dual Aspiration Technique in Stent-Assisted Mechanical Thrombectomy: Recent Improvements in Acute Stroke Management
ConclusionsThe dual aspiration technique with an additional intermediate guide catheter placed closed to the stent retriever leads to decreased procedure time in the anterior circulation. Even in cases with higher thrombus load and treated in DAT, clinical outcome improved.
Source: CardioVascular and Interventional Radiology - October 6, 2016 Category: Radiology Source Type: research

Elevated Red Cell Distribution Width is Associated with Cerebral Infarction in Aneurysmal Subarachnoid Hemorrhage
ConclusionsRDW elevation is associated with cerebral infarction and poor outcome after aSAH. Further evaluation of this association is warranted as it may shed light on mechanistic relations between anemia, inflammation, and thrombosis after aSAH.
Source: Neurocritical Care - August 15, 2016 Category: Neurology Source Type: research

Effective management of patients with acute ischemic stroke based on lean production on thrombolytic flow optimization
In this study, we aimed to determine whether applying lean principles to flow optimization could hasten the initiation of thrombolysis. A multidisciplinary team (Stroke Team) was organized to implement an ongoing, continuous loop of lean production that contained the following steps: decomposition, recognition, intervention, reengineering and assessment. The door-to-needle time (DNT) and the percentage of patients with DNT ≤ 60 min before and after the adoption of lean principles were used to evaluate the efficiency of our flow optimization. Thirteen patients with AIS in the pre-lean period and 43 patients with AIS in...
Source: Australasian Physical and Engineering Sciences in Medicine - April 18, 2016 Category: Biomedical Engineering Source Type: research

Severe Cerebral Venous and Sinus Thrombosis: Clinical Course, Imaging Correlates, and Prognosis
Conclusion The outcome of severe CVT is almost equally divided between severe impairment or death and survival with no or only mild handicap. Specifically, space-occupying mass effect and associated neurologic deterioration seem to determine a poor outcome. Therefore, early detection and treatment of mass effect should be the focus of critical care.
Source: Neurocritical Care - March 20, 2016 Category: Neurology Source Type: research

Severity and outcomes according to stroke etiology in patients under 50 years of age with ischemic stroke
Abstract To analyze the association of stroke etiological subtypes with severity and outcomes at 3 and 12 months in patients ≤50 years. Observational study of patients admitted to a stroke unit (2007–2013). Variables: demographic data, vascular risk factors, comorbidities, severity on admission (NIHSS), and good functional outcome (mRS ≤ 1) at 3 and 12 months. We used multivariate analyses to evaluate the influence of stroke etiology on severity and outcomes. We included 214 patients, 58.3 % men, mean age 41.4 years. General linear models showed all etiologies were more severe than lacunar strokes (PÂ...
Source: Journal of Thrombosis and Thrombolysis - February 5, 2016 Category: Hematology Source Type: research

Development of a decision analytic model to support decision making and risk communication about thrombolytic treatment
Conclusions: We have produced a DAM that provides an estimation of the likely benefits and risks of thrombolysis for individual patients, which has subsequently been embedded in a computerised decision aid to support better decision-making and informed consent.
Source: BMC Medical Informatics and Decision Making - November 11, 2015 Category: Information Technology Authors: Peter McMeekinDarren FlynnGary FordHelen RodgersJo GrayRichard Thompson Source Type: research

Thrombectomy assisted by carotid stenting in acute ischemic stroke management: benefits and harms
This study assesses the benefits and harms of thrombectomy assisted by carotid stenting and identifies factors associated with clinical outcome and procedural complications. Retrospective single-center analysis of 47 consecutive stroke patients with carotid occlusion or high-grade stenosis and concomitant intracranial embolus treated between September 2011 and December 2014. Benefits included early improvement of stroke severity (NIHSS ≥ 10) or complete remission within 72 h and favorable long-term outcome (mRS ≤ 2). Harms included complications during and following EVT. Mean age was 64.3 years (standard deviatio...
Source: Journal of Neurology - September 7, 2015 Category: Neurology Source Type: research

Influence of previous physical activity on the outcome of patients treated by thrombolytic therapy for stroke
Abstract Physical activity prevents stroke and is associated with less severe strokes. The neuroprotective effect in patients treated with intravenous (i.v.) recombinant tissue plasminogen activator (rt-PA), remains uncertain. We aimed at evaluating the relationship between previous physical activity and outcomes in stroke patients treated with i.v. rt-PA. OPHELIE-SPORT was a prospective observational multicenter study conducted in French and Japanese stroke patients treated with i.v. rt-PA. We evaluated the presence, weekly duration (<2, 2–5, >5 h) and intensity (light, moderate, heavy) of previous leisu...
Source: Journal of Neurology - August 14, 2015 Category: Neurology Source Type: research

Acute Stroke and Obstruction of the Extracranial Carotid Artery Combined with Intracranial Tandem Occlusion: Results of Interventional Revascularization
Conclusion Endovascular recanalization of acute cervical carotid artery occlusion was technically feasible in all patients, and resulted in high extra- and intracranial revascularization rates. A trend for favorable clinical outcome was seen in a higher TICI score, younger age, good collateral status, and combined IV rTPA and endovascular therapy.
Source: CardioVascular and Interventional Radiology - December 30, 2014 Category: Radiology Source Type: research

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