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Source: Atherosclerosis
Condition: Thrombosis
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Total 21 results found since Jan 2013.
ABI and stroke: Action at a distance and a call to action
Stroke is a catastrophic clinical event and is justifiably feared by both patients and physicians alike. Given the aging demographic of western populations, the morbid consequences of stroke are also a growing burden on healthcare resources . For example, projections show that by 2030 an additional 3.4 million US adults will have suffered a stroke, a 20.5% increase in prevalence from 2012 . The majority of strokes are ischemic and a consequence of either thromboembolism or atherosclerosis or both. Fortunately, effective primary prevention therapies exist, including aspirin and statins , which can reduce the risk of ischemi...
Source: Atherosclerosis - April 10, 2014 Category: Cardiology Authors: John W. McEvoy, Khurram Nasir Tags: Invited Commentaries Source Type: research
Toxic acrolein production due to Ca influx by the NMDA receptor during stroke
N-Methyl-D-aspartate (NMDA) receptors have a high permeability to Ca2+, contributing to neuronal cell death after stroke. We recently found that acrolein produced from polyamines is a major toxic compound during stroke. Thus, it was determined whether over-accumulation of Ca2+ increases the production of acrolein from polyamines in a photochemically-induced thrombosis mouse model of stroke and in cell culture systems.
Source: Atherosclerosis - November 13, 2015 Category: Cardiology Authors: Mizuho Nakamura, Takeshi Uemura, Ryotaro Saiki, Akihiko Sakamoto, Hyerim Park, Kazuhiro Nishimura, Yusuke Terui, Toshihiko Toida, Keiko Kashiwagi, Kazuei Igarashi Source Type: research
Ischaemic stroke and liver fibrosis
Stroke is the sudden onset of acute neurological injury arising as a result of cerebral haemorrhage or ischaemia. It is common and serious, with 16.9 million incident strokes deduced to have occurred in 2010 causing 5.9 million deaths worldwide. It is also a major cause of disability, incurring a significant healthcare burden. Ischaemic stroke is responsible for about 80% of cases in the developed world. Focal ischaemia results from blockage of a blood vessel by a thrombus or embolus, preventing blood supply to a region of the brain [1].
Source: Atherosclerosis - March 22, 2017 Category: Cardiology Authors: Ann P. Walker Tags: Editorial Source Type: research
Lack of association of plasma factor XI with incident stroke and coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) Study
We examined the association of factor XI with incident stroke and coronary heart disease in the prospective Atherosclerosis Risk in Communities (ARIC) Study.
Source: Atherosclerosis - September 10, 2015 Category: Cardiology Authors: Aaron R. Folsom, Kristen M. George, Duke Appiah Source Type: research
Atherosclerotic intracranial internal carotid artery calcification and intravenous thrombolytic therapy for acute ischemic stroke
Intracranial internal carotid artery calcification (IICAC) is a frequent and readily available finding in acute stroke patients treated with intravenous (IV) tissue plasminogen activator (tPA). We aimed to investigate the effects of IICAC subtype (medial and intimal) on the response to IV tPA.
Source: Atherosclerosis - January 31, 2018 Category: Cardiology Authors: Rahsan Gocmen, Ethem Murat Arsava, Kader Karli Oguz, Mehmet Akif Topcuoglu Source Type: research
Coronary and carotid atherosclerosis: Similarities and differences
Abstract: Although a relationship is commonly accepted between coronary and carotid arterial disease, suggesting that atherosclerosis is a systemic condition, the extent of this association and correspondence has not been fully elucidated. This review discusses recent research in this field and highlights areas for future study. The prevalence of severe carotid stenosis increases with prevalence of coronary stenosis, with the latter being found in a significant number of stroke patients, while those with carotid stenosis may be at higher risk of myocardial infarction than stroke. There also appear to be common risk factors...
Source: Atherosclerosis - December 7, 2012 Category: Cardiology Authors: Fisnik Jashari, Pranvera Ibrahimi, Rachel Nicoll, Gani Bajraktari, Per Wester, Michael Y. Henein Tags: Reviews Source Type: research
Determining carotid plaque vulnerability using ultrasound center frequency shifts
and Purpose: The leading cause of morbidity and mortality worldwide is atherosclerotic cardiovascular disease, most commonly caused by rupture of a high-risk plaque and subsequent thrombosis resulting in stroke, myocardial infarction or sudden death depending on the affected arterial territory. Accurate, non-invasive methods to identify such lesions known as vulnerable or high-risk plaques are currently sub-optimal. Our aim was to validate a new non-invasive ultrasound method to identify high-risk carotid plaques.
Source: Atherosclerosis - January 15, 2016 Category: Cardiology Authors: Tobias Erlöv, Magnus Cinthio, Andreas Edsfeldt, Simon Segstedt, Nuno Dias, Jan Nilsson, Isabel Gonçalves Source Type: research
CD98 promotes vascular smooth muscle cell accumulation in atherosclerosis to confer plaque stability
Atherosclerosis is a chronic progressive inflammatory disease and the leading cause of death worldwide. The major clinical consequences of atherosclerosis, such as myocardial infarction and stroke, are usually associated with a disruption of instable atherosclerotic plaques leading to thrombosis and embolism. Such instable plaques prone to rupture are characterized by a thin fibrous cap, high density of macrophages, and a large necrotic core. Conversely, a thick layer of VSMCs covering the necrotic core is considered to reduce the risk of plaque rupture.
Source: Atherosclerosis - November 25, 2016 Category: Cardiology Authors: Alma Zernecke Tags: Editorial Source Type: research
Promoter hypomethylation of microRNA223 gene is associated with atherosclerotic cerebral infarction
microRNA223 (miR-223) plays an important role in the development of atherosclerosis and ischemic stroke. It is involved in regulation of multiple physiological and pathophysiological processes such as cholesterol metabolism, endothelial cell (EC) function, and thrombosis. Here we investigated the role of methylation regulation of MIR-223 promoter region in atherosclerotic cerebral infarction (ACI) patients.
Source: Atherosclerosis - June 27, 2017 Category: Cardiology Authors: Zhibin Li, Fang Yu, Xiaoqing Zhou, Sian Zeng, Qiong Zhan, Mei Yuan, Qidong Yang, Yunhai Liu, Jian Xia Source Type: research
Inertial cavitation effect of catheter- based Q-switched ND:YAG laser enhance extracorporeal pulsed- focused ultrasound thrombolysis
Aim: A plaque may rupture with high risk of subsequent thrombus- mediated acute clinical events such as myocardial infarction and stroke. Catheter-based lasers have been extensively studied as an effective method to treat thrombosis. Focused ultrasound is one of the non- invasive methods to treat abnormal tissues. In pulsed- focused ultrasound with low duty cycle, which is used for thrombolysis, energy deposition rates are low enough that temperature rises are well below the threshold for thermal damage.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Hossein Mehrad, Mehdi Farhoudi, Alireza Paknezhad Source Type: research
Secretory phospholipase A2 modified high-density lipoprotein potently suppresses platelet activation
Aim: Levels of secretory phospholipases A2 (sPLA2) highly increase under acute and chronic inflammatory conditions. sPLA2 is mainly associated with high-density lipoproteins (HDL) and generates bioactive lysophospholipids implicated in acute and chronic inflammatory processes. Unexpectedly, pharmacological inhibition of sPLA2 in patients with acute coronary syndrome was associated with an increased risk of myocardial infarction and stroke. Given that platelets are key players in thrombosis and inflammation, we hypothesized that sPLA2-induced hydrolysis of HDL-associated phospholipids (sPLA2-HDL) generates modified HDL part...
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Gunther Marsche, Michael Holzer, Sanja Curcic Source Type: research
Relationship between thrombus age in aspirated coronary material and mid-term major adverse cardiac and cerebrovascular events in patients with acute myocardial infarction
Recent studies have shown that coronary thrombus histopathology is associated with impaired myocardial reperfusion and poor clinical outcome in patients with acute myocardial infarction (AMI). We sought to investigate the age of thrombi aspirated during percutaneous coronary intervention (PCI) in patients with AMI and evaluate the relationship between histopathologic findings and major adverse cardiac and cerebrovascular events (MACCEs) defined as all-cause death, stroke, or myocardial infarction within 6 months of PCI.
Source: Atherosclerosis - December 2, 2017 Category: Cardiology Authors: Kensaku Nishihira, Yoshisato Shibata, Atsushi Yamashita, Nehiro Kuriyama, Yujiro Asada Source Type: research
Photomechanical effect of Q-switched ND:YAG laser enhance thrombolysis using of PLGA- based encapsulated tissue plasminogen activator (TPA) nanoparticles
Aim: Thrombus formation on a disrupted atherosclerotic plaque is a key event that leads to atherothrombosis. Atherothrombosis mediated acute clinical events such as myocardial infarction and stroke. The purpose of this study is to prepare encapsulated tissue plasminogen activator (tPA) and evaluate its effectiveness on thrombolysis using laser therapy in the rabbit model of atherothrombotic.
Source: Atherosclerosis - August 1, 2018 Category: Cardiology Authors: H. Mehrad, J. Mahmoudi, A. Keshavarz, A. Rahimkhani Source Type: research
The association of adjusted Global AntiphosPholipid Syndrome Score (aGAPSS) with cardiovascular disease in subjects with antiphospholipid antibodies
Cardiovascular disease (CVD), including coronary artery disease and stroke/peripheral artery disease, is less commonly reported than venous thromboembolism in subjects with antiphospholipid antibodies (aPLs) and little is known about the association of CVD with adjusted Global AntiphosPholipid Syndrome Score (aGAPSS).
Source: Atherosclerosis - September 14, 2018 Category: Cardiology Authors: Matteo Nicola Dario Di Minno, Antonella Scalera, Antonella Tufano, Pasquale Ambrosino, Alessandra Bettiol, Elena Silvestri, Giacomo Emmi, Domenico Prisco Source Type: research
Developing Of A New Animal Artery Model Of Atherothrombotic Stenosis Using Radiofrequency Thermal Balloon Angioplasty- Mediated Endothelial Injury: Monitored By Color Doppler Ultrasonography And Histopathology
Background and Aims: A plaque may rupture with high risk of subsequent thrombus- mediated acute clinical events such as myocardial infarction and stroke. The aim of this study was to generate a reproducible experimental hamster abdominal aorta model of atherothrombotic stenosis with morphological similarities to the human disease.
Source: Atherosclerosis - August 4, 2019 Category: Cardiology Authors: H. mehrad Tags: Posters 26 - 29 May, 2019 Source Type: research
